1HKX

Crystal structure of calcium/calmodulin-dependent protein kinase

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d1hkxc_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
D	d1hkxd_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
E	d1hkxe_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
F	d1hkxf_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
G	d1hkxg_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
H	d1hkxh_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
J	d1hkxj_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
L	d1hkxl_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
N	d1hkxn_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d1hkxa_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d1hkxb_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
I	d1hkxi_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
K	d1hkxk_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
M	d1hkxm_	Alpha and beta proteins (a+b)	Cystatin-like	NTF2-like	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)
A	SCOP2 Family	Association domain of calcium/calmodulin-dependent protein kinase type II alpha subunit, CAMK2A	8032145	4000593	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	NTF2-like	8044523	3000472	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	NTF2-like	8044523	3000472	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	DUF4440	e1hkxC1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
D	DUF4440	e1hkxD1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
E	DUF4440	e1hkxE1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
F	DUF4440	e1hkxF1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
G	DUF4440	e1hkxG1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
H	DUF4440	e1hkxH1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
J	DUF4440	e1hkxJ1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
L	DUF4440	e1hkxL1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
N	DUF4440	e1hkxN1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
A	DUF4440	e1hkxA1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
B	DUF4440	e1hkxB1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
I	DUF4440	e1hkxI1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
K	DUF4440	e1hkxK1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)
M	DUF4440	e1hkxM1	A: a+b two layers	X: Cystatin-like	H: NTF2-like (From Topology)	T: NTF2-like	F: DUF4440	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
D	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
E	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
F	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
G	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
H	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
J	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
L	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
N	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
A	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
B	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
I	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
K	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
M	3.10.450.50	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	PF08332	Calcium/calmodulin dependent protein kinase II association domain (CaMKII_AD)	Calcium/calmodulin dependent protein kinase II association domain	This domain is found at the C-terminus of the Calcium/calmodulin dependent protein kinases II (CaMKII). These proteins also have a Ser/Thr protein kinase domain (Pfam:PF00069) at their N-terminus [1]. The function of the CaMKII association domain i ...	This domain is found at the C-terminus of the Calcium/calmodulin dependent protein kinases II (CaMKII). These proteins also have a Ser/Thr protein kinase domain (Pfam:PF00069) at their N-terminus [1]. The function of the CaMKII association domain is the assembly of the single proteins into large (8 to 14 subunits) multimers [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II ALPHA CHAIN	protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity calcium/calmodulin-dependent protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity calcium/calmodulin-dependent protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein binding calmodulin binding cation binding metal ion binding calcium-dependent protein serine/threonine kinase activity signaling receptor binding glutamate receptor binding GTPase activating protein binding protein serine kinase activity	membrane organization transport apoptotic mitochondrial changes biological regulation cell death establishment of localization cellular component organization mitochondrial membrane organization localization organelle organization cellular process regulation of membrane permeability regulation of mitochondrial membrane permeability involved in apoptotic process apoptotic process membrane organization transport apoptotic mitochondrial changes biological regulation cell death establishment of localization cellular component organization mitochondrial membrane organization localization organelle organization cellular process regulation of membrane permeability regulation of mitochondrial membrane permeability involved in apoptotic process apoptotic process cellular component organization or biogenesis regulation of biological quality regulation of mitochondrial membrane permeability programmed cell death mitochondrion organization mitochondrial transport cellular localization localization within membrane protein-containing complex localization neurotransmitter receptor diffusion trapping regulation of postsynaptic membrane neurotransmitter receptor levels receptor diffusion trapping receptor localization to synapse postsynaptic neurotransmitter receptor diffusion trapping response to stimulus response to stress response to ischemia cellular response to interferon-beta response to peptide response to interferon-beta response to chemical response to cytokine cellular response to cytokine stimulus regulation of localization regulation of cellular process modulation of chemical synaptic transmission signaling cell communication synaptic signaling regulation of secretion by cell secretion by cell signal release establishment of localization in cell trans-synaptic signaling regulation of biological process regulation of signaling neurotransmitter secretion regulation of transport secretion regulation of neurotransmitter transport export from cell cell-cell signaling neurotransmitter transport regulation of secretion chemical synaptic transmission signal release from synapse regulation of trans-synaptic signaling regulation of neurotransmitter secretion anterograde trans-synaptic signaling regulation of cell communication regulation of neuronal synaptic plasticity regulation of synaptic plasticity regulated exocytosis synaptic vesicle cycle synaptic vesicle exocytosis membrane docking vesicle-mediated transport vesicle-mediated transport in synapse organelle localization by membrane tethering organelle localization vesicle docking involved in exocytosis regulation of synaptic vesicle docking synaptic vesicle docking exocytosis vesicle docking exocytic process regulation of vesicle docking developmental process dendritic spine development multicellular organismal process plasma membrane bounded cell projection organization cellular developmental process cell projection organization cell development neuron projection development nervous system development generation of neurons neurogenesis multicellular organism development neuron differentiation dendrite development cell differentiation neuron development anatomical structure development system development regulation of calcium ion transport positive regulation of calcium ion transport regulation of monoatomic ion transport positive regulation of biological process calcium ion transport metal ion transport positive regulation of transport positive regulation of monoatomic ion transport monoatomic ion transport monoatomic cation transport regulation of metal ion transport mitotic cell cycle process cell cycle phase transition cell cycle G1/S transition of mitotic cell cycle cell cycle G1/S phase transition mitotic cell cycle mitotic cell cycle phase transition cell cycle process protein phosphorylation phosphorylation primary metabolic process peptidyl-serine modification peptidyl-serine phosphorylation macromolecule modification peptidyl-amino acid modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process cellular response to stimulus ligand-gated ion channel signaling pathway cell surface receptor signaling pathway ionotropic glutamate receptor signaling pathway glutamate receptor signaling pathway NMDA selective glutamate receptor signaling pathway signal transduction protein localization protein localization to cell periphery regulation of protein localization protein localization to plasma membrane regulation of protein localization to cell periphery protein localization to membrane regulation of cellular localization cellular macromolecule localization macromolecule localization regulation of protein localization to plasma membrane regulation of protein localization to membrane negative regulation of hydrolase activity regulation of molecular function regulation of catalytic activity regulation of hydrolase activity negative regulation of molecular function negative regulation of catalytic activity plasma membrane bounded cell projection morphogenesis cell morphogenesis cell projection morphogenesis neuron projection morphogenesis dendrite morphogenesis cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis establishment of protein localization nitrogen compound transport neurotransmitter receptor transport establishment of protein localization to membrane vesicle-mediated transport to the plasma membrane neurotransmitter receptor transport to plasma membrane protein transport regulation of cell motility neuron migration regulation of neuron migration regulation of locomotion regulation of cell migration cell migration cell motility locomotion cannabinoid signaling pathway regulation of signal transduction endocannabinoid signaling pathway regulation of response to stimulus G protein-coupled receptor signaling pathway regulation of G protein-coupled receptor signaling pathway regulation of endocannabinoid signaling pathway positive regulation of cardiac muscle cell apoptotic process positive regulation of programmed cell death muscle cell apoptotic process positive regulation of striated muscle cell apoptotic process regulation of apoptotic process regulation of cardiac muscle cell apoptotic process regulation of muscle cell apoptotic process regulation of programmed cell death positive regulation of apoptotic process cardiac muscle cell apoptotic process positive regulation of muscle cell apoptotic process regulation of striated muscle cell apoptotic process striated muscle cell apoptotic process positive regulation of cellular process protein autophosphorylation peptidyl-threonine autophosphorylation peptidyl-threonine modification peptidyl-threonine phosphorylation protein localization to synapse regulation of neurotransmitter receptor localization to postsynaptic specialization membrane regulation of protein localization to synapse neurotransmitter receptor localization to postsynaptic specialization membrane regulation of receptor localization to synapse protein localization to postsynaptic specialization membrane protein localization to postsynaptic membrane protein localization to organelle protein localization to postsynapse protein localization to cell junction positive regulation of cell communication cell surface receptor signaling pathway via STAT positive regulation of signal transduction positive regulation of receptor signaling pathway via STAT positive regulation of receptor signaling pathway via JAK-STAT positive regulation of response to stimulus regulation of receptor signaling pathway via JAK-STAT regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT positive regulation of signaling	somatodendritic compartment cell projection cellular anatomical structure dendrite dendritic tree neuron projection plasma membrane bounded cell projection intracellular anatomical structure cytoplasm synapse cell junction glutamatergic synapse protein-containing complex catalytic complex somatodendritic compartment cell projection cellular anatomical structure dendrite dendritic tree neuron projection plasma membrane bounded cell projection intracellular anatomical structure cytoplasm synapse cell junction glutamatergic synapse protein-containing complex catalytic complex calcium- and calmodulin-dependent protein kinase complex intracellular protein-containing complex neuron spine dendritic spine postsynapse cell body neuronal cell body axon membrane-bounded organelle intracellular organelle mitochondrion organelle intracellular membrane-bounded organelle cytosolic region presynapse presynaptic cytosol cytosol postsynaptic specialization membrane postsynaptic specialization membrane plasma membrane synaptic membrane cell periphery postsynaptic membrane plasma membrane region neuron projection cytoplasm cytoplasmic region plasma membrane bounded cell projection cytoplasm dendrite cytoplasm postsynaptic density neuron to neuron synapse asymmetric synapse Schaffer collateral - CA1 synapse glutamatergic postsynaptic density postsynaptic cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR000719	Protein kinase domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR032710	NTF2-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR013543	Calcium/calmodulin-dependent protein kinase II, association-domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR008271	Serine/threonine-protein kinase, active site	Active Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.