Annotations: 1PRT

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d1prtc1	All beta proteins	OB-fold	Bacterial enterotoxins	Bacterial AB5 toxins, B-subunits	Pertussis toxin S2/S3 subunits, C-terminal domain	(Bordetella pertussis ) [TaxId: 520 ],	SCOPe (2.08)
C	d1prtc2	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	Aerolysin/Pertussis toxin (APT) domain	Pertussis toxin, S2/S3 subunits, N-terminal domain	(Bordetella pertussis ) [TaxId: 520 ],	SCOPe (2.08)
I	d1prti1	All beta proteins	OB-fold	Bacterial enterotoxins	Bacterial AB5 toxins, B-subunits	Pertussis toxin S2/S3 subunits, C-terminal domain	(Bordetella pertussis ) [TaxId: 520 ],	SCOPe (2.08)
I	d1prti2	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	Aerolysin/Pertussis toxin (APT) domain	Pertussis toxin, S2/S3 subunits, N-terminal domain	(Bordetella pertussis ) [TaxId: 520 ],	SCOPe (2.08)
A	d1prta_	Alpha and beta proteins (a+b)	ADP-ribosylation	ADP-ribosylation	ADP-ribosylating toxins	Pertussis toxin, S1 subunit	(Bordetella pertussis ) [TaxId: 520 ],	SCOPe (2.08)
G	d1prtg_	Alpha and beta proteins (a+b)	ADP-ribosylation	ADP-ribosylation	ADP-ribosylating toxins	Pertussis toxin, S1 subunit	(Bordetella pertussis ) [TaxId: 520 ],	SCOPe (2.08)
B	d1prtb1	All beta proteins	OB-fold	Bacterial enterotoxins	Bacterial AB5 toxins, B-subunits	Pertussis toxin S2/S3 subunits, C-terminal domain	(Bordetella pertussis ) [TaxId: 520 ],	SCOPe (2.08)
B	d1prtb2	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	Aerolysin/Pertussis toxin (APT) domain	Pertussis toxin, S2/S3 subunits, N-terminal domain	(Bordetella pertussis ) [TaxId: 520 ],	SCOPe (2.08)
H	d1prth1	All beta proteins	OB-fold	Bacterial enterotoxins	Bacterial AB5 toxins, B-subunits	Pertussis toxin S2/S3 subunits, C-terminal domain	(Bordetella pertussis ) [TaxId: 520 ],	SCOPe (2.08)
H	d1prth2	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	Aerolysin/Pertussis toxin (APT) domain	Pertussis toxin, S2/S3 subunits, N-terminal domain	(Bordetella pertussis ) [TaxId: 520 ],	SCOPe (2.08)
D	d1prtd_	All beta proteins	OB-fold	Bacterial enterotoxins	Bacterial AB5 toxins, B-subunits	Pertussis toxin S4 subunit	(Bordetella pertussis ) [TaxId: 520 ],	SCOPe (2.08)
E	d1prte_	All beta proteins	OB-fold	Bacterial enterotoxins	Bacterial AB5 toxins, B-subunits	Pertussis toxin S4 subunit	(Bordetella pertussis ) [TaxId: 520 ],	SCOPe (2.08)
J	d1prtj_	All beta proteins	OB-fold	Bacterial enterotoxins	Bacterial AB5 toxins, B-subunits	Pertussis toxin S4 subunit	(Bordetella pertussis ) [TaxId: 520 ],	SCOPe (2.08)
K	d1prtk_	All beta proteins	OB-fold	Bacterial enterotoxins	Bacterial AB5 toxins, B-subunits	Pertussis toxin S4 subunit	(Bordetella pertussis ) [TaxId: 520 ],	SCOPe (2.08)
F	d1prtf_	All beta proteins	OB-fold	Bacterial enterotoxins	Bacterial AB5 toxins, B-subunits	Pertussis toxin S5 subunit	(Bordetella pertussis ) [TaxId: 520 ],	SCOPe (2.08)
L	d1prtl_	All beta proteins	OB-fold	Bacterial enterotoxins	Bacterial AB5 toxins, B-subunits	Pertussis toxin S5 subunit	(Bordetella pertussis ) [TaxId: 520 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	ADP-ribosylating toxins	8024625	4002404	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ADP-ribosylation	8037004	3001208	SCOP2 (2022-06-29)
G	SCOP2B Superfamily	ADP-ribosylation	8037004	3001208	SCOP2B (2022-06-29)
B	SCOP2 Family	Aerolysin/Pertussis toxin (APT) domain	8024744	4002495	SCOP2 (2022-06-29)
B	SCOP2 Family	Bacterial AB5 toxins, B-subunits	8029475	4001827	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	C-type lectin-like	8037123	3001261	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Bacterial enterotoxins	8041854	3000434	SCOP2 (2022-06-29)
H	SCOP2B Superfamily	Bacterial enterotoxins	8041854	3000434	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	C-type lectin-like	8037123	3001261	SCOP2B (2022-06-29)
D	SCOP2 Family	Bacterial AB5 toxins, B-subunits	8029483	4001827	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	Bacterial enterotoxins	8041862	3000434	SCOP2 (2022-06-29)
E	SCOP2B Superfamily	Bacterial enterotoxins	8041862	3000434	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Bacterial enterotoxins	8041862	3000434	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Bacterial enterotoxins	8041862	3000434	SCOP2B (2022-06-29)
F	SCOP2 Family	Bacterial AB5 toxins, B-subunits	8029484	4001827	SCOP2 (2022-06-29)
F	SCOP2 Superfamily	Bacterial enterotoxins	8041863	3000434	SCOP2 (2022-06-29)
L	SCOP2B Superfamily	Bacterial enterotoxins	8041863	3000434	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	Pertussis_S2S3	e1prtC1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Pertussis_S2S3	ECOD (1.6)
C	APT	e1prtC2	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: APT	ECOD (1.6)
I	Pertussis_S2S3	e1prtI1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Pertussis_S2S3	ECOD (1.6)
I	APT	e1prtI2	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: APT	ECOD (1.6)
A	Pertussis_S1	e1prtA1	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: Pertussis_S1	ECOD (1.6)
G	Pertussis_S1	e1prtG1	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: Pertussis_S1	ECOD (1.6)
B	Pertussis_S2S3	e1prtB1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Pertussis_S2S3	ECOD (1.6)
B	APT	e1prtB2	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: APT	ECOD (1.6)
H	Pertussis_S2S3	e1prtH1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Pertussis_S2S3	ECOD (1.6)
H	APT	e1prtH2	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: APT	ECOD (1.6)
D	Pertus-S4-tox	e1prtD1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Pertus-S4-tox	ECOD (1.6)
E	Pertus-S4-tox	e1prtE1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Pertus-S4-tox	ECOD (1.6)
J	Pertus-S4-tox	e1prtJ1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Pertus-S4-tox	ECOD (1.6)
K	Pertus-S4-tox	e1prtK1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Pertus-S4-tox	ECOD (1.6)
F	Pertus-S5-tox	e1prtF1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Pertus-S5-tox	ECOD (1.6)
L	Pertus-S5-tox	e1prtL1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Pertus-S5-tox	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	3.10.40.10	Alpha Beta	Roll	Pertussis Toxin	Chain B, domain 1	CATH (4.3.0)
C	2.40.50.110	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
I	3.10.40.10	Alpha Beta	Roll	Pertussis Toxin	Chain B, domain 1	CATH (4.3.0)
I	2.40.50.110	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
A	3.90.210.10	Alpha Beta	Alpha-Beta Complex	Heat-Labile Enterotoxin	Chain A	CATH (4.3.0)
G	3.90.210.10	Alpha Beta	Alpha-Beta Complex	Heat-Labile Enterotoxin	Chain A	CATH (4.3.0)
B	3.10.40.10	Alpha Beta	Roll	Pertussis Toxin	Chain B, domain 1	CATH (4.3.0)
B	2.40.50.110	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
H	3.10.40.10	Alpha Beta	Roll	Pertussis Toxin	Chain B, domain 1	CATH (4.3.0)
H	2.40.50.110	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
D	2.40.50.110	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
E	2.40.50.110	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
J	2.40.50.110	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
K	2.40.50.110	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
F	2.40.50.110	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
L	2.40.50.110	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C, I	PF03440	Aerolysin/Pertussis toxin (APT) domain (APT)	Aerolysin/Pertussis toxin (APT) domain	This family represents the N-terminal domain of aerolysin and pertussis toxin and has a type-C lectin like fold.	Domain
C, I	PF02918	Pertussis toxin, subunit 2 and 3, C-terminal domain (Pertussis_S2S3)	Pertussis toxin, subunit 2 and 3, C-terminal domain	-	Domain
A, G	PF02917	Pertussis toxin, subunit 1 (Pertussis_S1)	Pertussis toxin, subunit 1	-	Domain
B, H	PF03440	Aerolysin/Pertussis toxin (APT) domain (APT)	Aerolysin/Pertussis toxin (APT) domain	This family represents the N-terminal domain of aerolysin and pertussis toxin and has a type-C lectin like fold.	Domain
B, H	PF02918	Pertussis toxin, subunit 2 and 3, C-terminal domain (Pertussis_S2S3)	Pertussis toxin, subunit 2 and 3, C-terminal domain	-	Domain
D, E, J, K	PF09275	Pertussis toxin S4 subunit (Pertus-S4-tox)	Pertussis toxin S4 subunit	Members of this family of Bordetella pertussis toxins adopt a structure consisting of an OB fold, with a closed or partly opened beta-barrel in a Greek-key topology [1].	Domain
F, L	PF09276	Pertussis toxin S5 subunit (Pertus-S5-tox)	Pertussis toxin S5 subunit	Members of this family of Bordetella pertussis toxins adopt a structure consisting of an OB fold, with a closed or partly opened beta-barrel in a Greek-key topology [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C, I	PERTUSSIS TOXIN (SUBUNIT S3)	toxin activity	-	cellular anatomical structure membrane host cell plasma membrane host cellular component host cell part host cell membrane extracellular region
A, G	PERTUSSIS TOXIN (SUBUNIT S1)	pentosyltransferase activity catalytic activity, acting on a protein glycosyltransferase activity NAD+-protein ADP-ribosyltransferase activity transferase activity catalytic activity NAD+-protein poly-ADP-ribosyltransferase activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups toxin activity	-	cellular anatomical structure extracellular region
B, H	PERTUSSIS TOXIN (SUBUNIT S2)	toxin activity	-	cellular anatomical structure membrane host cell plasma membrane host cellular component host cell part host cell membrane extracellular region
D, E, J, K	PERTUSSIS TOXIN (SUBUNIT S4)	toxin activity	-	cellular anatomical structure membrane host cell plasma membrane host cellular component host cell part host cell membrane extracellular region
F, L	PERTUSSIS TOXIN (SUBUNIT S5)	toxin activity	-	cellular anatomical structure membrane host cell plasma membrane host cellular component host cell part host cell membrane extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C, I	IPR005138	Aerolysin/Pertussis toxin domain	Domain
C, I	IPR016187	C-type lectin fold	Homologous Superfamily
C, I	IPR037015	Aerolysin/Pertussis toxin (APT), N-terminal domain superfamily	Homologous Superfamily
C, I	IPR008992	Enterotoxin	Homologous Superfamily
C, I	IPR003899	Bordetella pertussis toxin B	Family
C, I	IPR020063	Bordetella pertussis toxin B, subunit 2/3, C-terminal	Domain
A, G	IPR003898	Bordetella pertussis toxin A	Family
B, H	IPR005138	Aerolysin/Pertussis toxin domain	Domain
B, H	IPR016187	C-type lectin fold	Homologous Superfamily
B, H	IPR037015	Aerolysin/Pertussis toxin (APT), N-terminal domain superfamily	Homologous Superfamily
B, H	IPR008992	Enterotoxin	Homologous Superfamily
B, H	IPR003899	Bordetella pertussis toxin B	Family
B, H	IPR020063	Bordetella pertussis toxin B, subunit 2/3, C-terminal	Domain
D, E, J, K	IPR015355	Pertussis toxin, subunit S4	Family
D, E, J, K	IPR008992	Enterotoxin	Homologous Superfamily
F, L	IPR015356	Pertussis toxin, subunit S5	Family
F, L	IPR008992	Enterotoxin	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.