2ICE

CRIg bound to C3c

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	A2M_N_1	e2iceA5	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: A2M_N_1	ECOD (1.6)
A	KOG1366_2nd_1	e2iceA3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: KOG1366_2nd_1	ECOD (1.6)
A	MG4	e2iceA4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: MG4	ECOD (1.6)
A	KOG1366_1st	e2iceA6	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: KOG1366_1st	ECOD (1.6)
A	ANATO	e2iceA7	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: ANATO	ECOD (1.6)
A	A2M_N_2	e2iceA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: A2M_N_2	ECOD (1.6)
E [auth D]	A2M_N_1	e2iceD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: A2M_N_1	ECOD (1.6)
E [auth D]	KOG1366_2nd_1	e2iceD5	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: KOG1366_2nd_1	ECOD (1.6)
E [auth D]	MG4	e2iceD4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: MG4	ECOD (1.6)
E [auth D]	KOG1366_1st	e2iceD6	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: KOG1366_1st	ECOD (1.6)
E [auth D]	ANATO	e2iceD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: ANATO	ECOD (1.6)
E [auth D]	A2M_N_2	e2iceD3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: A2M_N_2	ECOD (1.6)
F [auth E]	A2M_C	e2iceE3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: A2M_C	ECOD (1.6)
F [auth E]	A2M_N	e2iceE2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: A2M_N	ECOD (1.6)
B	A2M_C	e2iceB3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: A2M_C	ECOD (1.6)
B	A2M_N	e2iceB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: A2M_N	ECOD (1.6)
C	NTR	e2iceC1	A: beta barrels	X: OB-fold	H: TIMP-like (From Topology)	T: TIMP-like	F: NTR	ECOD (1.6)
C	A2M_recep	e2iceC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: A2M_recep	ECOD (1.6)
G [auth F]	NTR	e2iceF1	A: beta barrels	X: OB-fold	H: TIMP-like (From Topology)	T: TIMP-like	F: NTR	ECOD (1.6)
G [auth F]	A2M_recep	e2iceF2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: A2M_recep	ECOD (1.6)
D [auth S]	V-set_9	e2iceS1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_9	ECOD (1.6)
H [auth T]	V-set_9	e2iceT1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_9	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.1930	Mainly Beta	Sandwich	Immunoglobulin-like	Macroglobulin (MG2) domain	CATH (4.3.0)
A	2.60.40.1940	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
A	6.20.50.160	Special	Other non-globular	N-terminal domain of TfIIb		CATH (4.3.0)
E [auth D]	2.60.40.1930	Mainly Beta	Sandwich	Immunoglobulin-like	Macroglobulin (MG2) domain	CATH (4.3.0)
E [auth D]	2.60.40.1940	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
E [auth D]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
E [auth D]	6.20.50.160	Special	Other non-globular	N-terminal domain of TfIIb		CATH (4.3.0)
F [auth E]	2.20.130.20	Mainly Beta	Single Sheet	S-adenosyl-L-methionine-dependent methyltransferases		CATH (4.3.0)
F [auth E]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	2.20.130.20	Mainly Beta	Single Sheet	S-adenosyl-L-methionine-dependent methyltransferases		CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C	2.60.40.690	Mainly Beta	Sandwich	Immunoglobulin-like	Alpha-macroglobulin, receptor-binding domain	CATH (4.3.0)
C	2.40.50.120	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
G [auth F]	2.60.40.690	Mainly Beta	Sandwich	Immunoglobulin-like	Alpha-macroglobulin, receptor-binding domain	CATH (4.3.0)
G [auth F]	2.40.50.120	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
D [auth S]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
H [auth T]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
D [auth S], H [auth T]	VSIG4	1V-LIKE	Homo sapiens (human)	VSIG4*01	V-LIKE-DOMAIN V-LIKE	RPI	1V-LIKE_1V-LIKE	IMGT (202446-0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, E [auth D]	PF17790	Macroglobulin domain MG1 (MG1)	Macroglobulin domain MG1	This entry represents the N-terminal macroglobulin domain found in complement proteins C3, C4 and C5.	Domain
A, E [auth D]	PF17791	Macroglobulin domain MG3 (MG3)	Macroglobulin domain MG3	This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.	Domain
A, E [auth D]	PF01835	MG2 domain (MG2)	MG2 domain	This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes [1]. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. How ...	This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes [1]. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4 [2] [3].	Domain
A, E [auth D]	PF07703	Alpha-2-macroglobulin bait region domain (A2M_BRD)	Alpha-2-macroglobulin bait region domain	Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and spe ...	Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region [1] [2]. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognised as the Venus flytrap mechanism [1].	Domain
A, E [auth D]	PF17789	Macroglobulin domain MG4 (MG4)	Macroglobulin domain MG4	This domain is MG4 found in complement C3 and C5 proteins.	Domain
B, F [auth E]	PF00207	Alpha-2-macroglobulin family (A2M)	Alpha-2-macroglobulin family	-	Family
C, G [auth F]	PF01759	UNC-6/NTR/C345C module (NTR)	UNC-6/NTR/C345C module	Sequence similarity between netrin UNC-6 and C345C complement protein family members, and hence the existence of the UNC-6 module, was first reported in [1]. Subsequently, many additional members of the family were identified on the basis of sequence ...	Sequence similarity between netrin UNC-6 and C345C complement protein family members, and hence the existence of the UNC-6 module, was first reported in [1]. Subsequently, many additional members of the family were identified on the basis of sequence similarity between the C-terminal domains of netrins, complement proteins C3, C4, C5, secreted frizzled-related proteins, and type I pro-collagen C-proteinase enhancer proteins (PCOLCEs), which are homologous with the N-terminal domains of tissue inhibitors of metalloproteinases (TIMPs). The TIMPs are classified as a separate family in Pfam (Pfam:PF00965) [2]. This expanded domain family has been named as the NTR module [2].	Domain
C, G [auth F]	PF07677	A-macroglobulin receptor binding domain (A2M_recep)	A-macroglobulin receptor binding domain	This family includes the receptor binding domain region of the alpha-2-macroglobulin family.	Domain
D [auth S], H [auth T]	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, E [auth D]	Complement C3 beta chain	enzyme regulator activity molecular function inhibitor activity peptidase regulator activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity C5L2 anaphylatoxin chemotactic receptor binding protein binding binding signaling receptor binding G protein-coupled receptor binding C5a anaphylatoxin chemotactic receptor binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity C5L2 anaphylatoxin chemotactic receptor binding protein binding binding signaling receptor binding G protein-coupled receptor binding C5a anaphylatoxin chemotactic receptor binding molecular function activator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity	cellular response to stimulus positive regulation of cell communication regulation of biological process regulation of signaling regulation of cellular process positive regulation of signal transduction response to stimulus signaling biological regulation positive regulation of biological process regulation of signal transduction positive regulation of G protein-coupled receptor signaling pathway cell communication positive regulation of response to stimulus regulation of response to stimulus cellular response to stimulus positive regulation of cell communication regulation of biological process regulation of signaling regulation of cellular process positive regulation of signal transduction response to stimulus signaling biological regulation positive regulation of biological process regulation of signal transduction positive regulation of G protein-coupled receptor signaling pathway cell communication positive regulation of response to stimulus regulation of response to stimulus regulation of cell communication G protein-coupled receptor signaling pathway cellular process signal transduction regulation of G protein-coupled receptor signaling pathway positive regulation of cellular process positive regulation of signaling neutral lipid metabolic process neutral lipid biosynthetic process regulation of triglyceride metabolic process regulation of lipid metabolic process lipid biosynthetic process regulation of primary metabolic process acylglycerol biosynthetic process triglyceride metabolic process triglyceride biosynthetic process regulation of biosynthetic process regulation of triglyceride biosynthetic process primary metabolic process biosynthetic process glycerolipid biosynthetic process metabolic process glycerolipid metabolic process regulation of lipid biosynthetic process acylglycerol metabolic process regulation of metabolic process lipid metabolic process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity humoral immune response complement activation humoral immune response mediated by circulating immunoglobulin positive regulation of immune response leukocyte mediated immunity regulation of immune system process positive regulation of immune system process complement activation, classical pathway immune response immunoglobulin mediated immune response adaptive immune response immune effector process immune system process B cell mediated immunity regulation of immune response activation of immune response developmental process multicellular organismal process cellular developmental process cell development developmental maturation nervous system development generation of neurons neurogenesis multicellular organism development neuron differentiation neuron remodeling anatomical structure maturation cell differentiation neuron development anatomical structure development neuron maturation cell maturation system development B cell activation cell activation lymphocyte activation leukocyte activation regulation of humoral immune response regulation of immune effector process positive regulation of humoral immune response positive regulation of complement activation positive regulation of immune effector process activation of membrane attack complex positive regulation of activation of membrane attack complex regulation of activation of membrane attack complex regulation of complement activation visual system development pattern specification process regionalization central nervous system development sensory system development vertebrate eye-specific patterning regulation of localization hexose transmembrane transport regulation of transport transport carbohydrate transport establishment of localization positive regulation of D-glucose transmembrane transport transmembrane transport localization regulation of transmembrane transport positive regulation of transport D-glucose transmembrane transport positive regulation of transmembrane transport regulation of D-glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport import into cell positive regulation of cellular component organization regulation of cellular component organization vesicle-mediated transport cellular component organization positive regulation of endocytosis cellular component organization or biogenesis positive regulation of receptor-mediated endocytosis regulation of endocytosis regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport endocytosis receptor-mediated endocytosis biological process involved in interspecies interaction between organisms complement activation, alternative pathway response to biotic stimulus response to stress innate immune response response to external biotic stimulus response to other organism defense response defense response to symbiont response to external stimulus defense response to other organism epithelium development oviduct development reproductive system development oviduct epithelium development tube development reproductive process developmental process involved in reproduction tissue development reproductive structure development positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process regulation of cytokine production cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process regulation of vascular endothelial growth factor production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression vascular endothelial growth factor production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of vascular endothelial growth factor production regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of cytokine production positive regulation of membrane invagination regulation of phagocytosis, engulfment membrane invagination phagocytosis plasma membrane invagination membrane organization regulation of phagocytosis phagocytosis, engulfment positive regulation of phagocytosis positive regulation of phagocytosis, engulfment regulation of membrane invagination cellular component disassembly complement-mediated synapse pruning cell junction organization cell junction disassembly synapse pruning synapse organization immune response-regulating cell surface receptor signaling pathway complement receptor mediated signaling pathway immune response-activating signaling pathway immune response-regulating signaling pathway cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway amyloid-beta clearance lipid storage lipid localization positive regulation of lipid localization maintenance of location regulation of lipid storage regulation of lipid localization macromolecule localization positive regulation of lipid storage fatty acid metabolic process oxoacid metabolic process carboxylic acid metabolic process small molecule metabolic process monocarboxylic acid metabolic process organic acid metabolic process positive regulation of acute inflammatory response to antigenic stimulus regulation of myeloid leukocyte mediated immunity regulation of acute inflammatory response to antigenic stimulus positive regulation of leukocyte mediated immunity regulation of type IIa hypersensitivity myeloid leukocyte mediated immunity inflammatory response to antigenic stimulus positive regulation of hypersensitivity positive regulation of inflammatory response positive regulation of adaptive immune response regulation of type II hypersensitivity positive regulation of immunoglobulin mediated immune response hypersensitivity regulation of adaptive immune response regulation of inflammatory response regulation of B cell mediated immunity regulation of leukocyte mediated immunity type II hypersensitivity positive regulation of myeloid leukocyte mediated immunity type IIa hypersensitivity positive regulation of defense response regulation of acute inflammatory response inflammatory response regulation of defense response regulation of response to external stimulus positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity positive regulation of acute inflammatory response positive regulation of B cell mediated immunity regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of response to external stimulus regulation of immunoglobulin mediated immune response regulation of response to stress acute inflammatory response regulation of hypersensitivity regulation of inflammatory response to antigenic stimulus acute inflammatory response to antigenic stimulus positive regulation of inflammatory response to antigenic stimulus positive regulation of type IIa hypersensitivity regulation of lymphocyte mediated immunity positive regulation of type II hypersensitivity regulation of developmental process angiogenesis regulation of vasculature development positive regulation of developmental process tube morphogenesis regulation of anatomical structure morphogenesis blood vessel development regulation of multicellular organismal development blood vessel morphogenesis positive regulation of angiogenesis vasculature development circulatory system development anatomical structure morphogenesis positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis response to bacterium complement-dependent cytotoxicity cell killing positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of phosphate metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation positive regulation of apoptotic cell clearance apoptotic cell clearance regulation of apoptotic cell clearance	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen endoplasmic reticulum cytoplasm cell surface cell periphery plasma membrane membrane lytic vacuole intracellular vesicle cytoplasmic vesicle lumen vacuolar lumen cytoplasmic vesicle lysosome vesicle lumen azurophil granule vacuole secretory granule lumen azurophil granule lumen secretory granule primary lysosome secretory vesicle protein-containing complex blood microparticle
B, F [auth E]	Complement C3 alpha chain	enzyme regulator activity molecular function inhibitor activity peptidase regulator activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity C5L2 anaphylatoxin chemotactic receptor binding protein binding binding signaling receptor binding G protein-coupled receptor binding C5a anaphylatoxin chemotactic receptor binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity C5L2 anaphylatoxin chemotactic receptor binding protein binding binding signaling receptor binding G protein-coupled receptor binding C5a anaphylatoxin chemotactic receptor binding molecular function activator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity	cellular response to stimulus positive regulation of cell communication regulation of biological process regulation of signaling regulation of cellular process positive regulation of signal transduction response to stimulus signaling biological regulation positive regulation of biological process regulation of signal transduction positive regulation of G protein-coupled receptor signaling pathway cell communication positive regulation of response to stimulus regulation of response to stimulus cellular response to stimulus positive regulation of cell communication regulation of biological process regulation of signaling regulation of cellular process positive regulation of signal transduction response to stimulus signaling biological regulation positive regulation of biological process regulation of signal transduction positive regulation of G protein-coupled receptor signaling pathway cell communication positive regulation of response to stimulus regulation of response to stimulus regulation of cell communication G protein-coupled receptor signaling pathway cellular process signal transduction regulation of G protein-coupled receptor signaling pathway positive regulation of cellular process positive regulation of signaling neutral lipid metabolic process neutral lipid biosynthetic process regulation of triglyceride metabolic process regulation of lipid metabolic process lipid biosynthetic process regulation of primary metabolic process acylglycerol biosynthetic process triglyceride metabolic process triglyceride biosynthetic process regulation of biosynthetic process regulation of triglyceride biosynthetic process primary metabolic process biosynthetic process glycerolipid biosynthetic process metabolic process glycerolipid metabolic process regulation of lipid biosynthetic process acylglycerol metabolic process regulation of metabolic process lipid metabolic process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity humoral immune response complement activation humoral immune response mediated by circulating immunoglobulin positive regulation of immune response leukocyte mediated immunity regulation of immune system process positive regulation of immune system process complement activation, classical pathway immune response immunoglobulin mediated immune response adaptive immune response immune effector process immune system process B cell mediated immunity regulation of immune response activation of immune response developmental process multicellular organismal process cellular developmental process cell development developmental maturation nervous system development generation of neurons neurogenesis multicellular organism development neuron differentiation neuron remodeling anatomical structure maturation cell differentiation neuron development anatomical structure development neuron maturation cell maturation system development B cell activation cell activation lymphocyte activation leukocyte activation regulation of humoral immune response regulation of immune effector process positive regulation of humoral immune response positive regulation of complement activation positive regulation of immune effector process activation of membrane attack complex positive regulation of activation of membrane attack complex regulation of activation of membrane attack complex regulation of complement activation visual system development pattern specification process regionalization central nervous system development sensory system development vertebrate eye-specific patterning regulation of localization hexose transmembrane transport regulation of transport transport carbohydrate transport establishment of localization positive regulation of D-glucose transmembrane transport transmembrane transport localization regulation of transmembrane transport positive regulation of transport D-glucose transmembrane transport positive regulation of transmembrane transport regulation of D-glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport import into cell positive regulation of cellular component organization regulation of cellular component organization vesicle-mediated transport cellular component organization positive regulation of endocytosis cellular component organization or biogenesis positive regulation of receptor-mediated endocytosis regulation of endocytosis regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport endocytosis receptor-mediated endocytosis biological process involved in interspecies interaction between organisms complement activation, alternative pathway response to biotic stimulus response to stress innate immune response response to external biotic stimulus response to other organism defense response defense response to symbiont response to external stimulus defense response to other organism epithelium development oviduct development reproductive system development oviduct epithelium development tube development reproductive process developmental process involved in reproduction tissue development reproductive structure development positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process regulation of cytokine production cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process regulation of vascular endothelial growth factor production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression vascular endothelial growth factor production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of vascular endothelial growth factor production regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of cytokine production positive regulation of membrane invagination regulation of phagocytosis, engulfment membrane invagination phagocytosis plasma membrane invagination membrane organization regulation of phagocytosis phagocytosis, engulfment positive regulation of phagocytosis positive regulation of phagocytosis, engulfment regulation of membrane invagination cellular component disassembly complement-mediated synapse pruning cell junction organization cell junction disassembly synapse pruning synapse organization immune response-regulating cell surface receptor signaling pathway complement receptor mediated signaling pathway immune response-activating signaling pathway immune response-regulating signaling pathway cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway amyloid-beta clearance lipid storage lipid localization positive regulation of lipid localization maintenance of location regulation of lipid storage regulation of lipid localization macromolecule localization positive regulation of lipid storage fatty acid metabolic process oxoacid metabolic process carboxylic acid metabolic process small molecule metabolic process monocarboxylic acid metabolic process organic acid metabolic process positive regulation of acute inflammatory response to antigenic stimulus regulation of myeloid leukocyte mediated immunity regulation of acute inflammatory response to antigenic stimulus positive regulation of leukocyte mediated immunity regulation of type IIa hypersensitivity myeloid leukocyte mediated immunity inflammatory response to antigenic stimulus positive regulation of hypersensitivity positive regulation of inflammatory response positive regulation of adaptive immune response regulation of type II hypersensitivity positive regulation of immunoglobulin mediated immune response hypersensitivity regulation of adaptive immune response regulation of inflammatory response regulation of B cell mediated immunity regulation of leukocyte mediated immunity type II hypersensitivity positive regulation of myeloid leukocyte mediated immunity type IIa hypersensitivity positive regulation of defense response regulation of acute inflammatory response inflammatory response regulation of defense response regulation of response to external stimulus positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity positive regulation of acute inflammatory response positive regulation of B cell mediated immunity regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of response to external stimulus regulation of immunoglobulin mediated immune response regulation of response to stress acute inflammatory response regulation of hypersensitivity regulation of inflammatory response to antigenic stimulus acute inflammatory response to antigenic stimulus positive regulation of inflammatory response to antigenic stimulus positive regulation of type IIa hypersensitivity regulation of lymphocyte mediated immunity positive regulation of type II hypersensitivity regulation of developmental process angiogenesis regulation of vasculature development positive regulation of developmental process tube morphogenesis regulation of anatomical structure morphogenesis blood vessel development regulation of multicellular organismal development blood vessel morphogenesis positive regulation of angiogenesis vasculature development circulatory system development anatomical structure morphogenesis positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis response to bacterium complement-dependent cytotoxicity cell killing positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of phosphate metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation positive regulation of apoptotic cell clearance apoptotic cell clearance regulation of apoptotic cell clearance	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen endoplasmic reticulum cytoplasm cell surface cell periphery plasma membrane membrane lytic vacuole intracellular vesicle cytoplasmic vesicle lumen vacuolar lumen cytoplasmic vesicle lysosome vesicle lumen azurophil granule vacuole secretory granule lumen azurophil granule lumen secretory granule primary lysosome secretory vesicle protein-containing complex blood microparticle
C, G [auth F]	Complement C3 alpha chain	enzyme regulator activity molecular function inhibitor activity peptidase regulator activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity C5L2 anaphylatoxin chemotactic receptor binding protein binding binding signaling receptor binding G protein-coupled receptor binding C5a anaphylatoxin chemotactic receptor binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity C5L2 anaphylatoxin chemotactic receptor binding protein binding binding signaling receptor binding G protein-coupled receptor binding C5a anaphylatoxin chemotactic receptor binding molecular function activator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity	cellular response to stimulus positive regulation of cell communication regulation of biological process regulation of signaling regulation of cellular process positive regulation of signal transduction response to stimulus signaling biological regulation positive regulation of biological process regulation of signal transduction positive regulation of G protein-coupled receptor signaling pathway cell communication positive regulation of response to stimulus regulation of response to stimulus cellular response to stimulus positive regulation of cell communication regulation of biological process regulation of signaling regulation of cellular process positive regulation of signal transduction response to stimulus signaling biological regulation positive regulation of biological process regulation of signal transduction positive regulation of G protein-coupled receptor signaling pathway cell communication positive regulation of response to stimulus regulation of response to stimulus regulation of cell communication G protein-coupled receptor signaling pathway cellular process signal transduction regulation of G protein-coupled receptor signaling pathway positive regulation of cellular process positive regulation of signaling neutral lipid metabolic process neutral lipid biosynthetic process regulation of triglyceride metabolic process regulation of lipid metabolic process lipid biosynthetic process regulation of primary metabolic process acylglycerol biosynthetic process triglyceride metabolic process triglyceride biosynthetic process regulation of biosynthetic process regulation of triglyceride biosynthetic process primary metabolic process biosynthetic process glycerolipid biosynthetic process metabolic process glycerolipid metabolic process regulation of lipid biosynthetic process acylglycerol metabolic process regulation of metabolic process lipid metabolic process adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity humoral immune response complement activation humoral immune response mediated by circulating immunoglobulin positive regulation of immune response leukocyte mediated immunity regulation of immune system process positive regulation of immune system process complement activation, classical pathway immune response immunoglobulin mediated immune response adaptive immune response immune effector process immune system process B cell mediated immunity regulation of immune response activation of immune response developmental process multicellular organismal process cellular developmental process cell development developmental maturation nervous system development generation of neurons neurogenesis multicellular organism development neuron differentiation neuron remodeling anatomical structure maturation cell differentiation neuron development anatomical structure development neuron maturation cell maturation system development B cell activation cell activation lymphocyte activation leukocyte activation regulation of humoral immune response regulation of immune effector process positive regulation of humoral immune response positive regulation of complement activation positive regulation of immune effector process activation of membrane attack complex positive regulation of activation of membrane attack complex regulation of activation of membrane attack complex regulation of complement activation visual system development pattern specification process regionalization central nervous system development sensory system development vertebrate eye-specific patterning regulation of localization hexose transmembrane transport regulation of transport transport carbohydrate transport establishment of localization positive regulation of D-glucose transmembrane transport transmembrane transport localization regulation of transmembrane transport positive regulation of transport D-glucose transmembrane transport positive regulation of transmembrane transport regulation of D-glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport import into cell positive regulation of cellular component organization regulation of cellular component organization vesicle-mediated transport cellular component organization positive regulation of endocytosis cellular component organization or biogenesis positive regulation of receptor-mediated endocytosis regulation of endocytosis regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport endocytosis receptor-mediated endocytosis biological process involved in interspecies interaction between organisms complement activation, alternative pathway response to biotic stimulus response to stress innate immune response response to external biotic stimulus response to other organism defense response defense response to symbiont response to external stimulus defense response to other organism epithelium development oviduct development reproductive system development oviduct epithelium development tube development reproductive process developmental process involved in reproduction tissue development reproductive structure development positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process regulation of cytokine production cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process regulation of vascular endothelial growth factor production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression vascular endothelial growth factor production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of vascular endothelial growth factor production regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of cytokine production positive regulation of membrane invagination regulation of phagocytosis, engulfment membrane invagination phagocytosis plasma membrane invagination membrane organization regulation of phagocytosis phagocytosis, engulfment positive regulation of phagocytosis positive regulation of phagocytosis, engulfment regulation of membrane invagination cellular component disassembly complement-mediated synapse pruning cell junction organization cell junction disassembly synapse pruning synapse organization immune response-regulating cell surface receptor signaling pathway complement receptor mediated signaling pathway immune response-activating signaling pathway immune response-regulating signaling pathway cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway amyloid-beta clearance lipid storage lipid localization positive regulation of lipid localization maintenance of location regulation of lipid storage regulation of lipid localization macromolecule localization positive regulation of lipid storage fatty acid metabolic process oxoacid metabolic process carboxylic acid metabolic process small molecule metabolic process monocarboxylic acid metabolic process organic acid metabolic process positive regulation of acute inflammatory response to antigenic stimulus regulation of myeloid leukocyte mediated immunity regulation of acute inflammatory response to antigenic stimulus positive regulation of leukocyte mediated immunity regulation of type IIa hypersensitivity myeloid leukocyte mediated immunity inflammatory response to antigenic stimulus positive regulation of hypersensitivity positive regulation of inflammatory response positive regulation of adaptive immune response regulation of type II hypersensitivity positive regulation of immunoglobulin mediated immune response hypersensitivity regulation of adaptive immune response regulation of inflammatory response regulation of B cell mediated immunity regulation of leukocyte mediated immunity type II hypersensitivity positive regulation of myeloid leukocyte mediated immunity type IIa hypersensitivity positive regulation of defense response regulation of acute inflammatory response inflammatory response regulation of defense response regulation of response to external stimulus positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of lymphocyte mediated immunity positive regulation of acute inflammatory response positive regulation of B cell mediated immunity regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of response to external stimulus regulation of immunoglobulin mediated immune response regulation of response to stress acute inflammatory response regulation of hypersensitivity regulation of inflammatory response to antigenic stimulus acute inflammatory response to antigenic stimulus positive regulation of inflammatory response to antigenic stimulus positive regulation of type IIa hypersensitivity regulation of lymphocyte mediated immunity positive regulation of type II hypersensitivity regulation of developmental process angiogenesis regulation of vasculature development positive regulation of developmental process tube morphogenesis regulation of anatomical structure morphogenesis blood vessel development regulation of multicellular organismal development blood vessel morphogenesis positive regulation of angiogenesis vasculature development circulatory system development anatomical structure morphogenesis positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis response to bacterium complement-dependent cytotoxicity cell killing positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of phosphate metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation positive regulation of apoptotic cell clearance apoptotic cell clearance regulation of apoptotic cell clearance	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen endoplasmic reticulum cytoplasm cell surface cell periphery plasma membrane membrane lytic vacuole intracellular vesicle cytoplasmic vesicle lumen vacuolar lumen cytoplasmic vesicle lysosome vesicle lumen azurophil granule vacuole secretory granule lumen azurophil granule lumen secretory granule primary lysosome secretory vesicle protein-containing complex blood microparticle
D [auth S], H [auth T]	V-set and immunoglobulin domain-containing protein 4	opsonin binding protein binding binding complement component C3b binding complement binding	regulation of humoral immune response regulation of immune effector process response to stimulus negative regulation of biological process complement activation, alternative pathway response to biotic stimulus complement activation positive regulation of immune response regulation of immune system process positive regulation of immune system process regulation of biological process regulation of complement activation, alternative pathway immune response response to other organism regulation of humoral immune response regulation of immune effector process response to stimulus negative regulation of biological process complement activation, alternative pathway response to biotic stimulus complement activation positive regulation of immune response regulation of immune system process positive regulation of immune system process regulation of biological process regulation of complement activation, alternative pathway immune response response to other organism negative regulation of immune response regulation of innate immune response negative regulation of immune effector process negative regulation of humoral immune response response to external stimulus immune effector process regulation of response to stimulus defense response to other organism negative regulation of response to external stimulus negative regulation of defense response regulation of immune response negative regulation of complement activation, alternative pathway regulation of complement activation activation of immune response regulation of defense response humoral immune response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus negative regulation of response to biotic stimulus positive regulation of biological process negative regulation of complement activation positive regulation of response to stimulus response to stress regulation of response to stress innate immune response response to external biotic stimulus negative regulation of response to stimulus defense response biological regulation defense response to symbiont negative regulation of immune system process immune system process negative regulation of innate immune response multicellular organismal process regulation of cellular process negative regulation of interleukin-2 production regulation of cytokine production cytokine production negative regulation of cellular process regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of interleukin-2 production negative regulation of metabolic process interleukin-2 production negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process negative regulation of lymphocyte proliferation regulation of leukocyte activation regulation of cell activation negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of leukocyte proliferation T cell activation lymphocyte proliferation regulation of leukocyte proliferation cell population proliferation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion regulation of cell population proliferation mononuclear cell proliferation negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of leukocyte activation lymphocyte activation negative regulation of lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation negative regulation of mononuclear cell proliferation cell adhesion cell-cell adhesion regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation negative regulation of cell population proliferation regulation of cell adhesion cell activation regulation of T cell activation negative regulation of cell activation regulation of T cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation regulation of macrophage activation myeloid leukocyte activation macrophage activation negative regulation of macrophage activation	cellular anatomical structure membrane protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, E [auth D]	IPR019742	Alpha-2-macroglobulin, conserved site	Conserved Site
A, E [auth D]	IPR009048	Alpha-macroglobulin, receptor-binding	Domain
A, E [auth D]	IPR049466	Complement component 3, CUB domain, first segment	Domain
A, E [auth D]	IPR001599	Alpha-2-macroglobulin	Domain
A, E [auth D]	IPR001134	Netrin domain	Domain
A, E [auth D]	IPR011626	Alpha-macroglobulin-like, TED domain	Domain
A, E [auth D]	IPR002890	Macroglobulin domain	Domain
A, E [auth D]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, E [auth D]	IPR008930	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid	Homologous Superfamily
A, E [auth D]	IPR041555	Macroglobulin domain MG3	Domain
A, E [auth D]	IPR047565	Alpha-macroglobulin-like, thiol-ester bond-forming region	Conserved Site
A, E [auth D]	IPR048848	Complement component 3, CUB domain, second segment	Domain
A, E [auth D]	IPR018081	Anaphylatoxin, complement system	Homologous Superfamily
A, E [auth D]	IPR035815	Complement C3-like, NTR domain	Domain
A, E [auth D]	IPR018933	Netrin module, non-TIMP type	Domain
A, E [auth D]	IPR001840	Anaphylatoxin, complement system domain	Domain
A, E [auth D]	IPR041425	Complement C3/4/5, macroglobulin domain MG1	Domain
A, E [auth D]	IPR011625	Alpha-2-macroglobulin, bait region domain	Domain
A, E [auth D]	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold	Homologous Superfamily
A, E [auth D]	IPR000020	Anaphylatoxin/fibulin	Domain
A, E [auth D]	IPR036595	Alpha-macroglobulin, receptor-binding domain superfamily	Homologous Superfamily
A, E [auth D]	IPR050473	Alpha-2-macroglobulin/Complement system	Family
A, E [auth D]	IPR040839	Macroglobulin domain MG4	Domain
B, F [auth E]	IPR019742	Alpha-2-macroglobulin, conserved site	Conserved Site
B, F [auth E]	IPR009048	Alpha-macroglobulin, receptor-binding	Domain
B, F [auth E]	IPR049466	Complement component 3, CUB domain, first segment	Domain
B, F [auth E]	IPR001599	Alpha-2-macroglobulin	Domain
B, F [auth E]	IPR001134	Netrin domain	Domain
B, F [auth E]	IPR011626	Alpha-macroglobulin-like, TED domain	Domain
B, F [auth E]	IPR002890	Macroglobulin domain	Domain
B, F [auth E]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B, F [auth E]	IPR008930	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid	Homologous Superfamily
B, F [auth E]	IPR041555	Macroglobulin domain MG3	Domain
B, F [auth E]	IPR047565	Alpha-macroglobulin-like, thiol-ester bond-forming region	Conserved Site
B, F [auth E]	IPR048848	Complement component 3, CUB domain, second segment	Domain
B, F [auth E]	IPR018081	Anaphylatoxin, complement system	Homologous Superfamily
B, F [auth E]	IPR035815	Complement C3-like, NTR domain	Domain
B, F [auth E]	IPR018933	Netrin module, non-TIMP type	Domain
B, F [auth E]	IPR001840	Anaphylatoxin, complement system domain	Domain
B, F [auth E]	IPR041425	Complement C3/4/5, macroglobulin domain MG1	Domain
B, F [auth E]	IPR011625	Alpha-2-macroglobulin, bait region domain	Domain
B, F [auth E]	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold	Homologous Superfamily
B, F [auth E]	IPR000020	Anaphylatoxin/fibulin	Domain
B, F [auth E]	IPR036595	Alpha-macroglobulin, receptor-binding domain superfamily	Homologous Superfamily
B, F [auth E]	IPR050473	Alpha-2-macroglobulin/Complement system	Family
B, F [auth E]	IPR040839	Macroglobulin domain MG4	Domain
C, G [auth F]	IPR019742	Alpha-2-macroglobulin, conserved site	Conserved Site
C, G [auth F]	IPR009048	Alpha-macroglobulin, receptor-binding	Domain
C, G [auth F]	IPR049466	Complement component 3, CUB domain, first segment	Domain
C, G [auth F]	IPR001599	Alpha-2-macroglobulin	Domain
C, G [auth F]	IPR001134	Netrin domain	Domain
C, G [auth F]	IPR011626	Alpha-macroglobulin-like, TED domain	Domain
C, G [auth F]	IPR002890	Macroglobulin domain	Domain
C, G [auth F]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
C, G [auth F]	IPR008930	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid	Homologous Superfamily
C, G [auth F]	IPR041555	Macroglobulin domain MG3	Domain
C, G [auth F]	IPR047565	Alpha-macroglobulin-like, thiol-ester bond-forming region	Conserved Site
C, G [auth F]	IPR048848	Complement component 3, CUB domain, second segment	Domain
C, G [auth F]	IPR018081	Anaphylatoxin, complement system	Homologous Superfamily
C, G [auth F]	IPR035815	Complement C3-like, NTR domain	Domain
C, G [auth F]	IPR018933	Netrin module, non-TIMP type	Domain
C, G [auth F]	IPR001840	Anaphylatoxin, complement system domain	Domain
C, G [auth F]	IPR041425	Complement C3/4/5, macroglobulin domain MG1	Domain
C, G [auth F]	IPR011625	Alpha-2-macroglobulin, bait region domain	Domain
C, G [auth F]	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold	Homologous Superfamily
C, G [auth F]	IPR000020	Anaphylatoxin/fibulin	Domain
C, G [auth F]	IPR036595	Alpha-macroglobulin, receptor-binding domain superfamily	Homologous Superfamily
C, G [auth F]	IPR050473	Alpha-2-macroglobulin/Complement system	Family
C, G [auth F]	IPR040839	Macroglobulin domain MG4	Domain
D [auth S], H [auth T]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
D [auth S], H [auth T]	IPR003598	Immunoglobulin subtype 2	Domain
D [auth S], H [auth T]	IPR039944	VSIG4, immunoglobulin variable (IgV)-like domain	Domain
D [auth S], H [auth T]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
D [auth S], H [auth T]	IPR013106	Immunoglobulin V-set domain	Domain
D [auth S], H [auth T]	IPR003599	Immunoglobulin domain subtype	Domain
D [auth S], H [auth T]	IPR039939	V-set and immunoglobulin domain-containing protein 4	Family
D [auth S], H [auth T]	IPR007110	Immunoglobulin-like domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, E [auth D]	Pharos: P01024	complement component 3 deficiency age-related macular degeneration Henoch-Schoenlein purpura atypical hemolytic-uremic syndrome pemphigus age related macular degeneration 9 membranous glomerulonephritis Insulin Resistance pemphigus vulgaris transient ischemic attack atypical hemolytic-uremic syndrome with C3 anomaly primary immunodeficiency disease type 2 diabetes mellitus middle cerebral artery infarction hemolytic-uremic syndrome complement component 3 deficiency age-related macular degeneration Henoch-Schoenlein purpura atypical hemolytic-uremic syndrome pemphigus age related macular degeneration 9 membranous glomerulonephritis Insulin Resistance pemphigus vulgaris transient ischemic attack atypical hemolytic-uremic syndrome with C3 anomaly primary immunodeficiency disease type 2 diabetes mellitus middle cerebral artery infarction hemolytic-uremic syndrome paratuberculosis chronic kidney disease congestive heart failure juvenile dermatomyositis cystic fibrosis large cell medulloblastoma lung cancer subependymal giant cell astrocytoma malignant colon neoplasm acquired paroxysmal nocturnal hemoglobinuria maturity-onset diabetes of the young tuberculosis Emery-Dreifuss muscular dystrophy Gaucher disease hemolytic anemia non-small cell lung carcinoma Becker muscular dystrophy pancreatic intraductal papillary-mucinous carcinoma chronic obstructive pulmonary disease periodontitis kidney disease dermatomyositis Down syndrome lung carcinoma malignant ependymoma acute kidney failure Duchenne muscular dystrophy medulloblastoma adenoma Finnish type amyloidosis astrocytic tumor wet macular degeneration glioblastoma atypical teratoid rhabdoid tumor ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia idiopathic membranous glomerulonephritis pemphigus foliaceus invasive ductal breast carcinoma pilocytic astrocytoma psoriasis Creutzfeldt Jacob disease retinal degeneration diabetes mellitus limb-girdle muscular dystrophy Sjogren syndrome macular degeneration drug-induced liver injury malignant mesothelioma adrenal cortex carcinoma ulcerative colitis gastric carcinoma head and neck cancer myopathy autoimmune disease pancreatic ductal adenocarcinoma
B, F [auth E]	Pharos: P01024	complement component 3 deficiency age-related macular degeneration Henoch-Schoenlein purpura atypical hemolytic-uremic syndrome pemphigus age related macular degeneration 9 membranous glomerulonephritis Insulin Resistance pemphigus vulgaris transient ischemic attack atypical hemolytic-uremic syndrome with C3 anomaly primary immunodeficiency disease type 2 diabetes mellitus middle cerebral artery infarction hemolytic-uremic syndrome complement component 3 deficiency age-related macular degeneration Henoch-Schoenlein purpura atypical hemolytic-uremic syndrome pemphigus age related macular degeneration 9 membranous glomerulonephritis Insulin Resistance pemphigus vulgaris transient ischemic attack atypical hemolytic-uremic syndrome with C3 anomaly primary immunodeficiency disease type 2 diabetes mellitus middle cerebral artery infarction hemolytic-uremic syndrome paratuberculosis chronic kidney disease congestive heart failure juvenile dermatomyositis cystic fibrosis large cell medulloblastoma lung cancer subependymal giant cell astrocytoma malignant colon neoplasm acquired paroxysmal nocturnal hemoglobinuria maturity-onset diabetes of the young tuberculosis Emery-Dreifuss muscular dystrophy Gaucher disease hemolytic anemia non-small cell lung carcinoma Becker muscular dystrophy pancreatic intraductal papillary-mucinous carcinoma chronic obstructive pulmonary disease periodontitis kidney disease dermatomyositis Down syndrome lung carcinoma malignant ependymoma acute kidney failure Duchenne muscular dystrophy medulloblastoma adenoma Finnish type amyloidosis astrocytic tumor wet macular degeneration glioblastoma atypical teratoid rhabdoid tumor ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia idiopathic membranous glomerulonephritis pemphigus foliaceus invasive ductal breast carcinoma pilocytic astrocytoma psoriasis Creutzfeldt Jacob disease retinal degeneration diabetes mellitus limb-girdle muscular dystrophy Sjogren syndrome macular degeneration drug-induced liver injury malignant mesothelioma adrenal cortex carcinoma ulcerative colitis gastric carcinoma head and neck cancer myopathy autoimmune disease pancreatic ductal adenocarcinoma
C, G [auth F]	Pharos: P01024	complement component 3 deficiency age-related macular degeneration Henoch-Schoenlein purpura atypical hemolytic-uremic syndrome pemphigus age related macular degeneration 9 membranous glomerulonephritis Insulin Resistance pemphigus vulgaris transient ischemic attack atypical hemolytic-uremic syndrome with C3 anomaly primary immunodeficiency disease type 2 diabetes mellitus middle cerebral artery infarction hemolytic-uremic syndrome complement component 3 deficiency age-related macular degeneration Henoch-Schoenlein purpura atypical hemolytic-uremic syndrome pemphigus age related macular degeneration 9 membranous glomerulonephritis Insulin Resistance pemphigus vulgaris transient ischemic attack atypical hemolytic-uremic syndrome with C3 anomaly primary immunodeficiency disease type 2 diabetes mellitus middle cerebral artery infarction hemolytic-uremic syndrome paratuberculosis chronic kidney disease congestive heart failure juvenile dermatomyositis cystic fibrosis large cell medulloblastoma lung cancer subependymal giant cell astrocytoma malignant colon neoplasm acquired paroxysmal nocturnal hemoglobinuria maturity-onset diabetes of the young tuberculosis Emery-Dreifuss muscular dystrophy Gaucher disease hemolytic anemia non-small cell lung carcinoma Becker muscular dystrophy pancreatic intraductal papillary-mucinous carcinoma chronic obstructive pulmonary disease periodontitis kidney disease dermatomyositis Down syndrome lung carcinoma malignant ependymoma acute kidney failure Duchenne muscular dystrophy medulloblastoma adenoma Finnish type amyloidosis astrocytic tumor wet macular degeneration glioblastoma atypical teratoid rhabdoid tumor ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia idiopathic membranous glomerulonephritis pemphigus foliaceus invasive ductal breast carcinoma pilocytic astrocytoma psoriasis Creutzfeldt Jacob disease retinal degeneration diabetes mellitus limb-girdle muscular dystrophy Sjogren syndrome macular degeneration drug-induced liver injury malignant mesothelioma adrenal cortex carcinoma ulcerative colitis gastric carcinoma head and neck cancer myopathy autoimmune disease pancreatic ductal adenocarcinoma
D [auth S], H [auth T]	Pharos: Q9Y279	acute myeloid leukemia IgA glomerulonephritis non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma adrenal cortex carcinoma congestive heart failure head and neck cancer interstitial cystitis lung adenocarcinoma malignant colon neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm Acute Myeloid Leukemia (AML-M2) astrocytic tumor acute myeloid leukemia IgA glomerulonephritis non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma adrenal cortex carcinoma congestive heart failure head and neck cancer interstitial cystitis lung adenocarcinoma malignant colon neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm Acute Myeloid Leukemia (AML-M2) astrocytic tumor Duchenne muscular dystrophy hepatocellular carcinoma invasive ductal breast carcinoma lung cancer medulloblastoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia chronic obstructive pulmonary disease glioblastoma large cell medulloblastoma lung carcinoma