3LPO

Crystal structure of the N-terminal domain of sucrase-isomaltase

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Trefoil	8093210	3000849	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	YicI C-terminal domain-like	8093216	3000267	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Glycosyl hydrolase domain-like	8093214	3001528	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Galactose mutarotase-like	8093208	3000035	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	(Trans)glycosidases	8093212	3000313	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Trefoil	8093210	3000849	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Galactose mutarotase-like	8093208	3000035	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Glycosyl hydrolase domain-like	8093214	3001528	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	(Trans)glycosidases	8093212	3000313	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	YicI C-terminal domain-like	8093216	3000267	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	YicI C-terminal domain-like	8093216	3000267	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Glycosyl hydrolase domain-like	8093214	3001528	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Galactose mutarotase-like	8093208	3000035	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Trefoil	8093210	3000849	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	(Trans)glycosidases	8093212	3000313	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	YicI C-terminal domain-like	8093216	3000267	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	(Trans)glycosidases	8093212	3000313	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Trefoil	8093210	3000849	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Galactose mutarotase-like	8093208	3000035	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Glycosyl hydrolase domain-like	8093214	3001528	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Glyco_hydro_31_C	e3lpoA4	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycosyl hydrolase domain (From Topology)	T: Glycosyl hydrolase domain	F: Glyco_hydro_31_C	ECOD (1.6)
A	Gal_mutarotas_2	e3lpoA3	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: supersandwich (From Topology)	T: supersandwich	F: Gal_mutarotas_2	ECOD (1.6)
A	DUF5110_1	e3lpoA5	A: beta sandwiches	X: Putative glucosidase YicI, C-terminal domain (From Topology)	H: Putative glucosidase YicI, C-terminal domain (From Topology)	T: Putative glucosidase YicI, C-terminal domain	F: DUF5110_1	ECOD (1.6)
A	Glyco_hydro_31_N	e3lpoA2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glyco_hydro_31_N	ECOD (1.6)
A	Trefoil	e3lpoA6	A: few secondary structure elements	X: Trefoil/Plexin domain-like (From Topology)	H: Trefoil/Plexin domain-like (From Topology)	T: Trefoil/Plexin domain-like	F: Trefoil	ECOD (1.6)
B	Glyco_hydro_31_C	e3lpoB4	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycosyl hydrolase domain (From Topology)	T: Glycosyl hydrolase domain	F: Glyco_hydro_31_C	ECOD (1.6)
B	Gal_mutarotas_2	e3lpoB3	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: supersandwich (From Topology)	T: supersandwich	F: Gal_mutarotas_2	ECOD (1.6)
B	DUF5110_1	e3lpoB5	A: beta sandwiches	X: Putative glucosidase YicI, C-terminal domain (From Topology)	H: Putative glucosidase YicI, C-terminal domain (From Topology)	T: Putative glucosidase YicI, C-terminal domain	F: DUF5110_1	ECOD (1.6)
B	Glyco_hydro_31_N	e3lpoB2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glyco_hydro_31_N	ECOD (1.6)
B	Trefoil	e3lpoB6	A: few secondary structure elements	X: Trefoil/Plexin domain-like (From Topology)	H: Trefoil/Plexin domain-like (From Topology)	T: Trefoil/Plexin domain-like	F: Trefoil	ECOD (1.6)
C	Glyco_hydro_31_C	e3lpoC4	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycosyl hydrolase domain (From Topology)	T: Glycosyl hydrolase domain	F: Glyco_hydro_31_C	ECOD (1.6)
C	Gal_mutarotas_2	e3lpoC3	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: supersandwich (From Topology)	T: supersandwich	F: Gal_mutarotas_2	ECOD (1.6)
C	DUF5110_1	e3lpoC5	A: beta sandwiches	X: Putative glucosidase YicI, C-terminal domain (From Topology)	H: Putative glucosidase YicI, C-terminal domain (From Topology)	T: Putative glucosidase YicI, C-terminal domain	F: DUF5110_1	ECOD (1.6)
C	Glyco_hydro_31_N	e3lpoC2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glyco_hydro_31_N	ECOD (1.6)
C	Trefoil	e3lpoC6	A: few secondary structure elements	X: Trefoil/Plexin domain-like (From Topology)	H: Trefoil/Plexin domain-like (From Topology)	T: Trefoil/Plexin domain-like	F: Trefoil	ECOD (1.6)
D	Glyco_hydro_31_C	e3lpoD4	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycosyl hydrolase domain (From Topology)	T: Glycosyl hydrolase domain	F: Glyco_hydro_31_C	ECOD (1.6)
D	Gal_mutarotas_2	e3lpoD3	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: supersandwich (From Topology)	T: supersandwich	F: Gal_mutarotas_2	ECOD (1.6)
D	DUF5110_1	e3lpoD5	A: beta sandwiches	X: Putative glucosidase YicI, C-terminal domain (From Topology)	H: Putative glucosidase YicI, C-terminal domain (From Topology)	T: Putative glucosidase YicI, C-terminal domain	F: DUF5110_1	ECOD (1.6)
D	Glyco_hydro_31_N	e3lpoD2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glyco_hydro_31_N	ECOD (1.6)
D	Trefoil	e3lpoD6	A: few secondary structure elements	X: Trefoil/Plexin domain-like (From Topology)	H: Trefoil/Plexin domain-like (From Topology)	T: Trefoil/Plexin domain-like	F: Trefoil	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	4.10.110.10	Few Secondary Structures	Irregular	Spasmolytic Protein	domain 1	CATH (4.3.0)
A	2.60.40.1760	Mainly Beta	Sandwich	Immunoglobulin-like	glycosyl hydrolase (family 31)	CATH (4.3.0)
A	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
A	2.60.40.1180	Mainly Beta	Sandwich	Immunoglobulin-like	Golgi alpha-mannosidase II	CATH (4.3.0)
B	4.10.110.10	Few Secondary Structures	Irregular	Spasmolytic Protein	domain 1	CATH (4.3.0)
B	2.60.40.1760	Mainly Beta	Sandwich	Immunoglobulin-like	glycosyl hydrolase (family 31)	CATH (4.3.0)
B	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
B	2.60.40.1180	Mainly Beta	Sandwich	Immunoglobulin-like	Golgi alpha-mannosidase II	CATH (4.3.0)
C	4.10.110.10	Few Secondary Structures	Irregular	Spasmolytic Protein	domain 1	CATH (4.3.0)
C	2.60.40.1760	Mainly Beta	Sandwich	Immunoglobulin-like	glycosyl hydrolase (family 31)	CATH (4.3.0)
C	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
C	2.60.40.1180	Mainly Beta	Sandwich	Immunoglobulin-like	Golgi alpha-mannosidase II	CATH (4.3.0)
D	4.10.110.10	Few Secondary Structures	Irregular	Spasmolytic Protein	domain 1	CATH (4.3.0)
D	2.60.40.1760	Mainly Beta	Sandwich	Immunoglobulin-like	glycosyl hydrolase (family 31)	CATH (4.3.0)
D	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
D	2.60.40.1180	Mainly Beta	Sandwich	Immunoglobulin-like	Golgi alpha-mannosidase II	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF21365	Glycosyl hydrolase family 31 C-terminal domain (Glyco_hydro_31_3rd)	Glycosyl hydrolase family 31 C-terminal domain	Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases. This entry represents the 3rd beta sandwich domain.	Domain
A, B, C, D	PF13802	Glycosyl hydrolase 31 N-terminal galactose mutarotase-like domain (Gal_mutarotas_2)	Glycosyl hydrolase 31 N-terminal galactose mutarotase-like domain	This entry represents the first of three common domains found in Glycosyl hydrolase 31 family proteins. It has a galactose mutarotase superfamily fold.	Domain
A, B, C, D	PF01055	Glycosyl hydrolases family 31 TIM-barrel domain (Glyco_hydro_31_2nd)	Glycosyl hydrolases family 31 TIM-barrel domain	Glycosyl hydrolases are key enzymes of carbohydrate metabolism. Family 31 comprises of enzymes that are, or similar to, alpha- galactosidases. This entry corresponds to the second domain of family 31 enzymes and adopts a TIM-barrel fold.	Domain
A, B, C, D	PF00088	Trefoil (P-type) domain (Trefoil)	Trefoil (P-type) domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Sucrase-isomaltase	binding carbohydrate binding alpha-glucosidase activity hydrolase activity, acting on glycosyl bonds glucosidase activity beta-fructofuranosidase activity sucrose alpha-glucosidase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity catalytic activity alpha-1,4-glucosidase activity oligo-1,6-glucosidase activity	polysaccharide digestion multicellular organismal process digestion sucrose catabolic process carbohydrate metabolic process catabolic process oligosaccharide catabolic process oligosaccharide metabolic process carbohydrate catabolic process primary metabolic process disaccharide metabolic process sucrose metabolic process metabolic process cellular process polysaccharide digestion multicellular organismal process digestion sucrose catabolic process carbohydrate metabolic process catabolic process oligosaccharide catabolic process oligosaccharide metabolic process carbohydrate catabolic process primary metabolic process disaccharide metabolic process sucrose metabolic process metabolic process cellular process disaccharide catabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system cell periphery apical part of cell membrane plasma membrane plasma membrane region membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system cell periphery apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cluster of actin-based cell projections brush border

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR044913	P-type trefoil domain superfamily	Homologous Superfamily
A, B, C, D	IPR030459	Glycosyl hydrolases family 31, conserved site	Conserved Site
A, B, C, D	IPR000322	Glycoside hydrolase family 31, TIM barrel domain	Domain
A, B, C, D	IPR048395	Glycosyl hydrolase family 31, C-terminal domain	Domain
A, B, C, D	IPR017853	Glycoside hydrolase superfamily	Homologous Superfamily
A, B, C, D	IPR000519	P-type trefoil domain	Domain
A, B, C, D	IPR030458	Glycosyl hydrolases family 31, active site	Active Site
A, B, C, D	IPR017957	P-type trefoil, conserved site	Conserved Site
A, B, C, D	IPR013780	Glycosyl hydrolase, all-beta	Homologous Superfamily
A, B, C, D	IPR025887	Glycoside hydrolase family 31, N-terminal domain	Domain
A, B, C, D	IPR011013	Galactose mutarotase-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P14410	congenital sucrase-isomaltase deficiency type 2 diabetes mellitus Gaucher disease hypoglycemia DOID:0081062 glycogen storage disease malignant colon neoplasm ulcerative colitis Fabry disease hyperglycemia