Annotations: 4HR9

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Cystine-knot cytokines	8088224	3000846	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cystine-knot cytokines	8088224	3000846	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	IL17	e4hr9A1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: IL17	ECOD (1.6)
B	IL17	e4hr9B1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: IL17	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	CATH (4.3.0)
B	2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF06083	Interleukin-17 (IL17)	Interleukin-17	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Interleukin-17A	protein heterodimerization activity protein binding binding protein dimerization activity identical protein binding protein homodimerization activity molecular function activator activity signaling receptor binding molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity	regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response negative regulation of biological process regulation of response to wounding response to stress regulation of response to stress response to wounding regulation of biological process regulation of inflammatory response to wounding defense response negative regulation of response to stimulus biological regulation regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response negative regulation of biological process regulation of response to wounding response to stress regulation of response to stress response to wounding regulation of biological process regulation of inflammatory response to wounding defense response negative regulation of response to stimulus biological regulation response to external stimulus regulation of inflammatory response negative regulation of response to wounding negative regulation of inflammatory response to wounding regulation of response to stimulus negative regulation of response to external stimulus inflammatory response to wounding negative regulation of defense response inflammatory response cellular response to stimulus regulation of cellular process cell surface receptor signaling pathway signaling response to cytokine interleukin-17A-mediated signaling pathway cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular response to cytokine stimulus cellular process signal transduction developmental process epithelium development epidermal cell differentiation cellular developmental process epidermis development animal organ development tissue development epithelial cell differentiation skin development cell differentiation keratinocyte differentiation anatomical structure development immune response immune system process adaptive immune response interleukin-6 production multicellular organismal process positive regulation of biological process positive regulation of macromolecule biosynthetic process positive regulation of interleukin-6 production regulation of interleukin-6 production positive regulation of metabolic process positive regulation of biosynthetic process regulation of cytokine production cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process apoptotic process cell death programmed cell death biological process involved in interspecies interaction between organisms response to other organism defense response to symbiont response to biotic stimulus defense response to other organism innate immune response response to external biotic stimulus cell population proliferation epithelial cell proliferation keratinocyte proliferation cell-cell signaling chemokine (C-X-C motif) ligand 1 production regulation of chemokine production chemokine production positive regulation of chemokine production regulation of chemokine (C-X-C motif) ligand 1 production positive regulation of chemokine (C-X-C motif) ligand 1 production fibroblast activation cell activation regulation of interleukin-12 production interleukin-12 production positive regulation of interleukin-12 production cellular response to interleukin-17 response to interleukin-17 interleukin-17-mediated signaling pathway leukocyte migration myeloid leukocyte migration cell migration cell motility granulocyte migration interleukin-1 production regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production positive regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production regulation of humoral immune response regulation of immune effector process positive regulation of response to biotic stimulus antimicrobial humoral immune response mediated by antimicrobial peptide positive regulation of immune response regulation of immune system process positive regulation of immune system process immune effector process positive regulation of defense response positive regulation of production of molecular mediator of immune response regulation of immune response regulation of production of molecular mediator of immune response humoral immune response regulation of response to biotic stimulus antimicrobial humoral response positive regulation of response to stimulus positive regulation of antimicrobial peptide production positive regulation of humoral immune response positive regulation of response to external stimulus antimicrobial peptide production positive regulation of immune effector process production of molecular mediator of immune response regulation of antimicrobial humoral response positive regulation of antimicrobial humoral response regulation of antimicrobial peptide production defense response to fungus response to fungus positive regulation of interleukin-23 production interleukin-23 production regulation of interleukin-23 production positive regulation of interleukin-16 production regulation of interleukin-16 production interleukin-16 production defense response to Gram-negative bacterium defense response to bacterium response to bacterium system process epithelial structure maintenance homeostatic process digestive system process intestinal epithelial structure maintenance tissue homeostasis maintenance of gastrointestinal epithelium digestion multicellular organismal-level homeostasis anatomical structure homeostasis regulation of cytokine production involved in inflammatory response production of molecular mediator involved in inflammatory response cytokine production involved in inflammatory response positive regulation of cytokine production involved in inflammatory response regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production Notch signaling pathway positive regulation of DNA-templated transcription RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process primary metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription cellular response to interleukin-1 response to interleukin-1 bicellular tight junction assembly positive regulation of cellular component organization regulation of cellular component organization tight junction organization cellular component organization cellular component biogenesis cellular component assembly cell junction assembly cellular component organization or biogenesis cell-cell junction assembly cell-cell junction organization regulation of bicellular tight junction assembly positive regulation of cellular component biogenesis regulation of cellular component biogenesis apical junction assembly regulation of cell junction assembly positive regulation of cell junction assembly positive regulation of bicellular tight junction assembly cell junction organization tight junction assembly defense response to Gram-positive bacterium myeloid leukocyte differentiation regulation of leukocyte differentiation regulation of developmental process cell development regulation of cell differentiation positive regulation of osteoclast differentiation regulation of cell development positive regulation of developmental process regulation of osteoclast differentiation multicellular organism development positive regulation of cell differentiation positive regulation of hemopoiesis osteoclast differentiation regulation of multicellular organismal development hemopoiesis regulation of myeloid cell differentiation positive regulation of cell development regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation myeloid cell differentiation positive regulation of myeloid cell differentiation regulation of hemopoiesis positive regulation of leukocyte differentiation leukocyte differentiation	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR029034	Cystine-knot cytokine	Homologous Superfamily
A, B	IPR010345	Interleukin-17 family	Family
A, B	IPR020440	Interleukin-17, chordata	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q16552	acute promyelocytic leukemia allergic disease pneumonia autoimmune disease Arthritis, Experimental brain ischemia multiple sclerosis central nervous system disease graft versus host disease colitis ankylosing spondylitis COVID-19 pneumonitis pulmonary edema tuberculosis acute promyelocytic leukemia allergic disease pneumonia autoimmune disease Arthritis, Experimental brain ischemia multiple sclerosis central nervous system disease graft versus host disease colitis ankylosing spondylitis COVID-19 pneumonitis pulmonary edema tuberculosis drug-induced liver injury vasculitis acute lung injury inborn carbohydrate metabolic disorder arthritic joint disease influenza psoriasis demyelinating disease ulcerative colitis X-linked lymphoproliferative syndrome hypereosinophilic syndrome kidney disease asthma cancer obesity disorder psoriatic arthritis diarrheal disease skin disease uveitis exocrine pancreatic carcinoma alcohol abuse inflammatory bowel disease liver disease lymphoproliferative syndrome candidiasis periodontitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.