Annotations: 5AFM

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d5afmc_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ], GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
E	d5afme_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ], GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
A	d5afma_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ], GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
D	d5afmd_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	automated matches	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ], GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
B	d5afmb_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ], GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ], human (Homo sapiens ) [TaxId: 9606 ], GREAT POND SNAIL (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	Neur_chan_LBD	e5afmC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
E	Neur_chan_LBD	e5afmE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
A	Neur_chan_LBD	e5afmA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
D	Neur_chan_LBD	e5afmD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
B	Neur_chan_LBD	e5afmB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
E	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
A	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
D	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
B	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, D, E	PF02931	Neurotransmitter-gated ion-channel ligand binding domain (Neur_chan_LBD)	Neurotransmitter-gated ion-channel ligand binding domain	-	Family
B	PF02931	Neurotransmitter-gated ion-channel ligand binding domain (Neur_chan_LBD)	Neurotransmitter-gated ion-channel ligand binding domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, D, E	ACETYLCHOLINE-BINDING PROTEIN, NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-7	transmitter-gated monoatomic ion channel activity molecular transducer activity gated channel activity monoatomic ion channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential signaling receptor activity neurotransmitter receptor activity ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity postsynaptic neurotransmitter receptor activity passive transmembrane transporter activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential channel activity transmitter-gated channel activity transmitter-gated monoatomic ion channel activity molecular transducer activity gated channel activity monoatomic ion channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential signaling receptor activity neurotransmitter receptor activity ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity postsynaptic neurotransmitter receptor activity passive transmembrane transporter activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential channel activity transmitter-gated channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity excitatory extracellular ligand-gated monoatomic ion channel activity transmembrane signaling receptor activity amide binding amyloid-beta binding binding peptide binding acetylcholine receptor activity toxic substance binding channel regulator activity ion channel regulator activity molecular function regulator activity transporter regulator activity chloride channel regulator activity calcium channel activity monoatomic cation transmembrane transporter activity monoatomic cation channel activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity metal ion transmembrane transporter activity cation binding acetylcholine binding ion binding small molecule binding identical protein binding protein binding protein homodimerization activity protein dimerization activity acetylcholine-gated monoatomic cation-selective channel activity ligand-gated monoatomic cation channel activity	cellular response to stimulus multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process response to stimulus signaling modulation of chemical synaptic transmission regulation of system process regulation of signal transduction chemical synaptic transmission, postsynaptic cell communication synaptic signaling modulation of excitatory postsynaptic potential cellular response to stimulus multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process response to stimulus signaling modulation of chemical synaptic transmission regulation of system process regulation of signal transduction chemical synaptic transmission, postsynaptic cell communication synaptic signaling modulation of excitatory postsynaptic potential regulation of multicellular organismal process signal transduction regulation of biological quality trans-synaptic signaling regulation of biological process regulation of signaling cell surface receptor signaling pathway nervous system process biological regulation cell-cell signaling chemical synaptic transmission regulation of nervous system process regulation of trans-synaptic signaling regulation of response to stimulus anterograde trans-synaptic signaling regulation of cell communication cellular process excitatory postsynaptic potential regulation of membrane potential positive regulation of cell communication positive regulation of signal transduction positive regulation of excitatory postsynaptic potential positive regulation of biological process positive regulation of response to stimulus positive regulation of cellular process positive regulation of signaling regulation of tumor necrosis factor production negative regulation of biological process negative regulation of tumor necrosis factor production cytokine production regulation of cytokine production negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of metabolic process tumor necrosis factor superfamily cytokine production negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process tumor necrosis factor production regulation of gene expression negative regulation of gene expression regulation of tumor necrosis factor superfamily cytokine production biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of tumor necrosis factor superfamily cytokine production metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process localization transport monoatomic ion transport establishment of localization regulation of CoA-transferase activity regulation of molecular function positive regulation of molecular function positive regulation of transferase activity regulation of catalytic activity positive regulation of CoA-transferase activity positive regulation of catalytic activity regulation of transferase activity amyloid precursor protein catabolic process regulation of protein metabolic process regulation of amyloid precursor protein catabolic process primary metabolic process regulation of primary metabolic process protein metabolic process amyloid precursor protein metabolic process cognition behavior learning or memory memory inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis cellular component organization cell junction organization dendritic spine organization postsynapse organization plasma membrane bounded cell projection organization cell projection organization neuron projection organization synapse organization cellular component organization or biogenesis regulation of amide metabolic process regulation of amyloid-beta formation negative regulation of amyloid precursor protein catabolic process amyloid-beta metabolic process amide metabolic process negative regulation of protein metabolic process amyloid-beta formation negative regulation of amyloid-beta formation negative regulation of amide metabolic process response to decreased oxygen levels response to hypoxia response to stress response to oxygen levels response to abiotic stimulus regulation of cellular component organization regulation of amyloid fibril formation amyloid fibril formation regulation of supramolecular fiber organization supramolecular fiber organization cellular response to nitrogen compound cellular response to acetylcholine response to oxygen-containing compound response to nitrogen compound acetylcholine receptor signaling pathway postsynaptic signal transduction cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical response to acetylcholine cellular developmental process plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis dendrite development cell differentiation anatomical structure development system development developmental process dendrite arborization dendrite morphogenesis nervous system development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron projection arborization neuron development positive regulation of protein metabolic process positive regulation of metabolic process positive regulation of macromolecule metabolic process intracellular signal transduction positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade long-term synaptic potentiation positive regulation of long-term synaptic potentiation regulation of synaptic plasticity positive regulation of synaptic transmission regulation of long-term synaptic potentiation transmembrane transport monoatomic ion transmembrane transport cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation response to amyloid-beta sensory perception sensory processing positive regulation of amyloid-beta formation positive regulation of amide metabolic process positive regulation of amyloid precursor protein catabolic process short-term memory regulation of developmental process angiogenesis regulation of vasculature development positive regulation of developmental process tube morphogenesis regulation of anatomical structure morphogenesis blood vessel development regulation of multicellular organismal development blood vessel morphogenesis tube development positive regulation of angiogenesis vasculature development circulatory system development positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis positive regulation of multicellular organismal process positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of phosphate metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation monoatomic cation transport calcium ion transport metal ion transport response to nicotine	cellular anatomical structure synaptic cleft extracellular region membrane postsynapse synapse cell junction cell projection neuron projection plasma membrane bounded cell projection cell periphery postsynaptic membrane plasma membrane plasma membrane region cellular anatomical structure synaptic cleft extracellular region membrane postsynapse synapse cell junction cell projection neuron projection plasma membrane bounded cell projection cell periphery postsynaptic membrane plasma membrane plasma membrane region synaptic membrane protein-containing complex plasma membrane protein complex membrane protein complex transporter complex receptor complex acetylcholine-gated channel complex transmembrane transporter complex plasma membrane signaling receptor complex monoatomic ion channel complex membrane microdomain membrane raft plasma membrane raft
B	ACETYLCHOLINE-BINDING PROTEIN, NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA-7	transmitter-gated monoatomic ion channel activity molecular transducer activity gated channel activity monoatomic ion channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential signaling receptor activity neurotransmitter receptor activity ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity postsynaptic neurotransmitter receptor activity passive transmembrane transporter activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential channel activity transmitter-gated channel activity transmitter-gated monoatomic ion channel activity molecular transducer activity gated channel activity monoatomic ion channel activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential signaling receptor activity neurotransmitter receptor activity ligand-gated channel activity ligand-gated monoatomic ion channel activity extracellular ligand-gated monoatomic ion channel activity postsynaptic neurotransmitter receptor activity passive transmembrane transporter activity neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential channel activity transmitter-gated channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity excitatory extracellular ligand-gated monoatomic ion channel activity transmembrane signaling receptor activity amide binding amyloid-beta binding binding peptide binding acetylcholine receptor activity toxic substance binding channel regulator activity ion channel regulator activity molecular function regulator activity transporter regulator activity chloride channel regulator activity calcium channel activity monoatomic cation transmembrane transporter activity monoatomic cation channel activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity metal ion transmembrane transporter activity cation binding acetylcholine binding ion binding small molecule binding identical protein binding protein binding protein homodimerization activity protein dimerization activity acetylcholine-gated monoatomic cation-selective channel activity ligand-gated monoatomic cation channel activity	cellular response to stimulus multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process response to stimulus signaling modulation of chemical synaptic transmission regulation of system process regulation of signal transduction chemical synaptic transmission, postsynaptic cell communication synaptic signaling modulation of excitatory postsynaptic potential cellular response to stimulus multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process response to stimulus signaling modulation of chemical synaptic transmission regulation of system process regulation of signal transduction chemical synaptic transmission, postsynaptic cell communication synaptic signaling modulation of excitatory postsynaptic potential regulation of multicellular organismal process signal transduction regulation of biological quality trans-synaptic signaling regulation of biological process regulation of signaling cell surface receptor signaling pathway nervous system process biological regulation cell-cell signaling chemical synaptic transmission regulation of nervous system process regulation of trans-synaptic signaling regulation of response to stimulus anterograde trans-synaptic signaling regulation of cell communication cellular process excitatory postsynaptic potential regulation of membrane potential positive regulation of cell communication positive regulation of signal transduction positive regulation of excitatory postsynaptic potential positive regulation of biological process positive regulation of response to stimulus positive regulation of cellular process positive regulation of signaling regulation of tumor necrosis factor production negative regulation of biological process negative regulation of tumor necrosis factor production cytokine production regulation of cytokine production negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of metabolic process tumor necrosis factor superfamily cytokine production negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process tumor necrosis factor production regulation of gene expression negative regulation of gene expression regulation of tumor necrosis factor superfamily cytokine production biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of tumor necrosis factor superfamily cytokine production metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process localization transport monoatomic ion transport establishment of localization regulation of CoA-transferase activity regulation of molecular function positive regulation of molecular function positive regulation of transferase activity regulation of catalytic activity positive regulation of CoA-transferase activity positive regulation of catalytic activity regulation of transferase activity amyloid precursor protein catabolic process regulation of protein metabolic process regulation of amyloid precursor protein catabolic process primary metabolic process regulation of primary metabolic process protein metabolic process amyloid precursor protein metabolic process cognition behavior learning or memory memory inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis cellular component organization cell junction organization dendritic spine organization postsynapse organization plasma membrane bounded cell projection organization cell projection organization neuron projection organization synapse organization cellular component organization or biogenesis regulation of amide metabolic process regulation of amyloid-beta formation negative regulation of amyloid precursor protein catabolic process amyloid-beta metabolic process amide metabolic process negative regulation of protein metabolic process amyloid-beta formation negative regulation of amyloid-beta formation negative regulation of amide metabolic process response to decreased oxygen levels response to hypoxia response to stress response to oxygen levels response to abiotic stimulus regulation of cellular component organization regulation of amyloid fibril formation amyloid fibril formation regulation of supramolecular fiber organization supramolecular fiber organization cellular response to nitrogen compound cellular response to acetylcholine response to oxygen-containing compound response to nitrogen compound acetylcholine receptor signaling pathway postsynaptic signal transduction cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical response to acetylcholine cellular developmental process plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis dendrite development cell differentiation anatomical structure development system development developmental process dendrite arborization dendrite morphogenesis nervous system development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron projection arborization neuron development positive regulation of protein metabolic process positive regulation of metabolic process positive regulation of macromolecule metabolic process intracellular signal transduction positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade long-term synaptic potentiation positive regulation of long-term synaptic potentiation regulation of synaptic plasticity positive regulation of synaptic transmission regulation of long-term synaptic potentiation transmembrane transport monoatomic ion transmembrane transport cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation response to amyloid-beta sensory perception sensory processing positive regulation of amyloid-beta formation positive regulation of amide metabolic process positive regulation of amyloid precursor protein catabolic process short-term memory regulation of developmental process angiogenesis regulation of vasculature development positive regulation of developmental process tube morphogenesis regulation of anatomical structure morphogenesis blood vessel development regulation of multicellular organismal development blood vessel morphogenesis tube development positive regulation of angiogenesis vasculature development circulatory system development positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis positive regulation of multicellular organismal process positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of phosphate metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation monoatomic cation transport calcium ion transport metal ion transport response to nicotine	cellular anatomical structure synaptic cleft extracellular region membrane postsynapse synapse cell junction cell projection neuron projection plasma membrane bounded cell projection cell periphery postsynaptic membrane plasma membrane plasma membrane region cellular anatomical structure synaptic cleft extracellular region membrane postsynapse synapse cell junction cell projection neuron projection plasma membrane bounded cell projection cell periphery postsynaptic membrane plasma membrane plasma membrane region synaptic membrane protein-containing complex plasma membrane protein complex membrane protein complex transporter complex receptor complex acetylcholine-gated channel complex transmembrane transporter complex plasma membrane signaling receptor complex monoatomic ion channel complex membrane microdomain membrane raft plasma membrane raft

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, D, E	IPR007110	Immunoglobulin-like domain	Domain
A, C, D, E	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
A, C, D, E	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
A, C, D, E	IPR006201	Neurotransmitter-gated ion-channel	Family
A, C, D, E	IPR002394	Nicotinic acetylcholine receptor	Family
A, C, D, E	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
A, C, D, E	IPR018000	Neurotransmitter-gated ion-channel, conserved site	Conserved Site
A, C, D, E	IPR038050	Neuronal acetylcholine receptor	Homologous Superfamily
A, C, D, E	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
A, C, D, E	IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily	Homologous Superfamily
A, C, D, E	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain	Domain
A, C, D, E	IPR006201	Neurotransmitter-gated ion-channel	Family
B	IPR007110	Immunoglobulin-like domain	Domain
B	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
B	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
B	IPR006201	Neurotransmitter-gated ion-channel	Family
B	IPR002394	Nicotinic acetylcholine receptor	Family
B	IPR036734	Neurotransmitter-gated ion-channel ligand-binding domain superfamily	Homologous Superfamily
B	IPR018000	Neurotransmitter-gated ion-channel, conserved site	Conserved Site
B	IPR038050	Neuronal acetylcholine receptor	Homologous Superfamily
B	IPR006202	Neurotransmitter-gated ion-channel ligand-binding domain	Domain
B	IPR036719	Neurotransmitter-gated ion-channel transmembrane domain superfamily	Homologous Superfamily
B	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain	Domain
B	IPR006201	Neurotransmitter-gated ion-channel	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C, D, E	Pharos: P36544	chromosome 15q13.3 microdeletion syndrome Alzheimer disease Sudden infant death syndrome nicotine dependence spina bifida cystica auditory perceptual disorders substance withdrawal syndrome visual epilepsy omphalocele schizophrenia onchocerciasis lung benign neoplasm bipolar disorder brain injury myelomeningocele chromosome 15q13.3 microdeletion syndrome Alzheimer disease Sudden infant death syndrome nicotine dependence spina bifida cystica auditory perceptual disorders substance withdrawal syndrome visual epilepsy omphalocele schizophrenia onchocerciasis lung benign neoplasm bipolar disorder brain injury myelomeningocele epilepsy, idiopathic generalized autism glaucoma strongyloidiasis
B	Pharos: P36544	chromosome 15q13.3 microdeletion syndrome Alzheimer disease Sudden infant death syndrome nicotine dependence spina bifida cystica auditory perceptual disorders substance withdrawal syndrome visual epilepsy omphalocele schizophrenia onchocerciasis lung benign neoplasm bipolar disorder brain injury myelomeningocele chromosome 15q13.3 microdeletion syndrome Alzheimer disease Sudden infant death syndrome nicotine dependence spina bifida cystica auditory perceptual disorders substance withdrawal syndrome visual epilepsy omphalocele schizophrenia onchocerciasis lung benign neoplasm bipolar disorder brain injury myelomeningocele epilepsy, idiopathic generalized autism glaucoma strongyloidiasis