5NI4
Crystal structure of human LTA4H mutant E271A in complex with LTA4 (crystal form II)
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | Leukotriene A4 hydrolase N-terminal domain | 8038930 | 3000390 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | ARM repeat-like | 8038928 | 3000116 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Metalloproteases (zincins), catalytic domain | 8038934 | 3001975 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | Leukotriene A4 hydrolase N-terminal domain | 8038930 | 3000390 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | Metalloproteases (zincins), catalytic domain | 8038934 | 3001975 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | ARM repeat-like | 8038928 | 3000116 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | ARM repeat-like | 8038928 | 3000116 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Leukotriene A4 hydrolase N-terminal domain | 8038930 | 3000390 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Metalloproteases (zincins), catalytic domain | 8038934 | 3001975 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | Peptidase_M1_2 | e5ni4A2 | A: beta sandwiches | X: Baculovirus p35 protein-related (From Topology) | H: Baculovirus p35 protein-related (From Topology) | T: Baculovirus p35 protein-related | F: Peptidase_M1_2 | ECOD (1.6) |
A | Leuk-A4-hydro_C | e5ni4A3 | A: alpha superhelices | X: Repetitive alpha hairpins | H: ARM repeat (From Topology) | T: ARM repeat | F: Leuk-A4-hydro_C | ECOD (1.6) |
A | Peptidase_M1_1 | e5ni4A1 | A: mixed a+b and a/b | X: Zincin-like | H: Metalloproteases (zincins) catalytic domain (From Topology) | T: Metalloproteases (zincins) catalytic domain | F: Peptidase_M1_1 | ECOD (1.6) |
C | Peptidase_M1_2 | e5ni4C3 | A: beta sandwiches | X: Baculovirus p35 protein-related (From Topology) | H: Baculovirus p35 protein-related (From Topology) | T: Baculovirus p35 protein-related | F: Peptidase_M1_2 | ECOD (1.6) |
C | Leuk-A4-hydro_C | e5ni4C2 | A: alpha superhelices | X: Repetitive alpha hairpins | H: ARM repeat (From Topology) | T: ARM repeat | F: Leuk-A4-hydro_C | ECOD (1.6) |
C | Peptidase_M1_1 | e5ni4C1 | A: mixed a+b and a/b | X: Zincin-like | H: Metalloproteases (zincins) catalytic domain (From Topology) | T: Metalloproteases (zincins) catalytic domain | F: Peptidase_M1_1 | ECOD (1.6) |
B | Peptidase_M1_2 | e5ni4B1 | A: beta sandwiches | X: Baculovirus p35 protein-related (From Topology) | H: Baculovirus p35 protein-related (From Topology) | T: Baculovirus p35 protein-related | F: Peptidase_M1_2 | ECOD (1.6) |
B | Leuk-A4-hydro_C | e5ni4B2 | A: alpha superhelices | X: Repetitive alpha hairpins | H: ARM repeat (From Topology) | T: ARM repeat | F: Leuk-A4-hydro_C | ECOD (1.6) |
B | Peptidase_M1_1 | e5ni4B3 | A: mixed a+b and a/b | X: Zincin-like | H: Metalloproteases (zincins) catalytic domain (From Topology) | T: Metalloproteases (zincins) catalytic domain | F: Peptidase_M1_1 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF09127 | Leukotriene A4 hydrolase, C-terminal (Leuk-A4-hydro_C) | Leukotriene A4 hydrolase, C-terminal | - | Repeat | |
PF01433 | Peptidase family M1 domain (Peptidase_M1) | Peptidase family M1 domain | Members of this family are aminopeptidases. The members differ widely in specificity, hydrolysing acidic, basic or neutral N-terminal residues. This family includes leukotriene-A4 hydrolase Swiss:P09960, this enzyme also has an aminopeptidase activ ... | Domain | |
PF17900 | Peptidase M1 N-terminal domain (Peptidase_M1_N) | Peptidase M1 N-terminal domain | This domain is found at the N-terminus of aminopeptidases from the M1 family. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR034015 | Aminopeptidase, leukotriene A4 hydrolase-like | Family | |
IPR001930 | Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase | Family | |
IPR016024 | Armadillo-type fold | Homologous Superfamily | |
IPR012777 | Leukotriene A4 hydrolase/leucine aminopeptidase | Family | |
IPR042097 | Aminopeptidase N-like , N-terminal domain superfamliy | Homologous Superfamily | |
IPR049980 | Leukotriene A4 hydrolase-like, catalytic domain | Domain | |
IPR015211 | Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal | Domain | |
IPR038502 | Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily | Homologous Superfamily | |
IPR027268 | Peptidase M4/M1, CTD superfamily | Homologous Superfamily | |
IPR014782 | Peptidase M1, membrane alanine aminopeptidase | Domain | |
IPR045357 | Aminopeptidase N-like , N-terminal domain | Domain |