7X4X

BTB domain of KEAP1 in complex with MEF

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth E]	SCOP2B Superfamily	POZ domain	8080945	3000894	SCOP2B (2022-06-29)
B [auth D]	SCOP2B Superfamily	POZ domain	8080945	3000894	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	POZ domain	8080945	3000894	SCOP2B (2022-06-29)
D [auth B]	SCOP2B Superfamily	POZ domain	8080945	3000894	SCOP2B (2022-06-29)
E [auth A]	SCOP2B Superfamily	POZ domain	8080945	3000894	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	POZ domain	8080945	3000894	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth E]	F_UNCLASSIFIED	e7x4xE1	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth D]	F_UNCLASSIFIED	e7x4xD1	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e7x4xC1	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: F_UNCLASSIFIED	ECOD (1.6)
D [auth B]	F_UNCLASSIFIED	e7x4xB1	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: F_UNCLASSIFIED	ECOD (1.6)
E [auth A]	F_UNCLASSIFIED	e7x4xA1	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: F_UNCLASSIFIED	ECOD (1.6)
F	F_UNCLASSIFIED	e7x4xF1	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth E], B [auth D], C, D [auth B], E [auth A], A [auth E], B [auth D], C, D [auth B], E [auth A], F	PF00651	BTB/POZ domain (BTB)	BTB/POZ domain	The BTB (for BR-C, ttk and bab) [1] or POZ (for Pox virus and Zinc finger) [2] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family o ...	The BTB (for BR-C, ttk and bab) [1] or POZ (for Pox virus and Zinc finger) [2] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [2]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [3]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [4,5,6]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth E], B [auth D], C, D [auth B], E [auth A], A [auth E], B [auth D], C, D [auth B], E [auth A], F	Kelch-like ECH-associated protein 1	transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding ubiquitin-like ligase-substrate adaptor activity enzyme-substrate adaptor activity protein-macromolecule adaptor activity molecular adaptor activity disordered domain specific binding protein domain specific binding identical protein binding	developmental process multicellular organismal process epithelium development regulation of biological process regulation of multicellular organismal development regulation of cellular process cellular developmental process regulation of developmental process epidermal cell differentiation regulation of epidermal cell differentiation epidermis development biological regulation regulation of cell differentiation tissue development epithelial cell differentiation developmental process multicellular organismal process epithelium development regulation of biological process regulation of multicellular organismal development regulation of cellular process cellular developmental process regulation of developmental process epidermal cell differentiation regulation of epidermal cell differentiation epidermis development biological regulation regulation of cell differentiation tissue development epithelial cell differentiation regulation of epithelial cell differentiation multicellular organism development cell differentiation anatomical structure development cellular process regulation of multicellular organismal process regulation of epidermis development negative regulation of DNA-binding transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process negative regulation of molecular function primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of molecular function regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process response to interleukin-4 response to peptide response to stimulus response to chemical response to cytokine cellular response to cytokine stimulus cellular response to interleukin-4 positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process positive regulation of biological process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process positive regulation of metabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process positive regulation of cellular process regulation of protein metabolic process proteasomal protein catabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process regulation of protein catabolic process protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal negative regulation of response to stimulus negative regulation of biological process response to oxidative stress regulation of response to stimulus response to stress regulation of response to stress regulation of response to oxidative stress negative regulation of response to oxidative stress cellular response to stimulus cellular response to chemical stimulus cellular response to stress cellular response to oxidative stress cellular response to chemical stress embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development autophagy regulation of autophagy process utilizing autophagic mechanism	midbody cellular anatomical structure intracellular anatomical structure intracellular membraneless organelle intracellular organelle centrosome microtubule organizing center cytoskeleton centriolar satellite organelle membraneless organelle microtubule cytoskeleton cytoplasm cytosol midbody cellular anatomical structure intracellular anatomical structure intracellular membraneless organelle intracellular organelle centrosome microtubule organizing center cytoskeleton centriolar satellite organelle membraneless organelle microtubule cytoskeleton cytoplasm cytosol inclusion body membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen polymeric cytoskeletal fiber actin filament actin cytoskeleton supramolecular fiber supramolecular polymer supramolecular complex cullin-RING ubiquitin ligase complex protein-containing complex ubiquitin ligase complex catalytic complex transferase complex Cul3-RING ubiquitin ligase complex intracellular protein-containing complex endoplasmic reticulum endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth E], B [auth D], C, D [auth B], E [auth A], A [auth E], B [auth D], C, D [auth B], E [auth A], F	IPR000210	BTB/POZ domain	Domain
A [auth E], B [auth D], C, D [auth B], E [auth A], A [auth E], B [auth D], C, D [auth B], E [auth A], F	IPR015915	Kelch-type beta propeller	Homologous Superfamily
A [auth E], B [auth D], C, D [auth B], E [auth A], A [auth E], B [auth D], C, D [auth B], E [auth A], F	IPR006652	Kelch repeat type 1	Repeat
A [auth E], B [auth D], C, D [auth B], E [auth A], A [auth E], B [auth D], C, D [auth B], E [auth A], F	IPR011705	BTB/Kelch-associated	Domain
A [auth E], B [auth D], C, D [auth B], E [auth A], A [auth E], B [auth D], C, D [auth B], E [auth A], F	IPR017096	BTB-kelch protein	Family
A [auth E], B [auth D], C, D [auth B], E [auth A], A [auth E], B [auth D], C, D [auth B], E [auth A], F	IPR030563	Kelch-like ECH-associated protein 1, BTB/POZ domain	Domain
A [auth E], B [auth D], C, D [auth B], E [auth A], A [auth E], B [auth D], C, D [auth B], E [auth A], F	IPR047098	Kelch-like ECH-associated protein 1, BACK domain	Domain
A [auth E], B [auth D], C, D [auth B], E [auth A], A [auth E], B [auth D], C, D [auth B], E [auth A], F	IPR011333	SKP1/BTB/POZ domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth E], B [auth D], C, D [auth B], E [auth A], A [auth E], B [auth D], C, D [auth B], E [auth A], F	Pharos: Q14145	renal cell carcinoma keratosis lung cancer non-small cell lung carcinoma collecting duct carcinoma gallbladder cancer chromophobe renal cell carcinoma sarcomatoid renal cell carcinoma hepatitis papillary renal cell carcinoma prostate cancer Hepatomegaly ankylosing spondylitis digestive system disease inflammatory bowel disease renal cell carcinoma keratosis lung cancer non-small cell lung carcinoma collecting duct carcinoma gallbladder cancer chromophobe renal cell carcinoma sarcomatoid renal cell carcinoma hepatitis papillary renal cell carcinoma prostate cancer Hepatomegaly ankylosing spondylitis digestive system disease inflammatory bowel disease lung disease osteosarcoma astrocytic tumor primary biliary cholangitis relapsing-remitting multiple sclerosis extrahepatic cholestasis gallbladder neoplasm lung adenocarcinoma cancer clear cell renal carcinoma renal carcinoma Crohn disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.