Annotations: 8R3Y

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B [auth L]	Lethal(2) giant larvae protein homolog 1	GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity cytoskeletal protein binding protein binding binding myosin II binding myosin binding kinase binding enzyme binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity cytoskeletal protein binding protein binding binding myosin II binding myosin binding kinase binding enzyme binding protein kinase binding structural molecule activity	cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation regulation of signal transduction cell communication Notch signaling pathway regulation of response to stimulus regulation of Notch signaling pathway regulation of cell communication cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation regulation of signal transduction cell communication Notch signaling pathway regulation of response to stimulus regulation of Notch signaling pathway regulation of cell communication cellular process signal transduction cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis Golgi to plasma membrane transport cellular localization post-Golgi vesicle-mediated transport transport localization within membrane establishment of localization vesicle-mediated transport vesicle-mediated transport to the plasma membrane localization Golgi vesicle transport regulation of establishment or maintenance of cell polarity establishment or maintenance of cell polarity establishment of organelle localization microtubule cytoskeleton organization spindle localization establishment of cell polarity organelle organization establishment of spindle localization establishment of spindle orientation organelle localization establishment of localization in cell microtubule-based process cell cycle cytoskeleton organization cell cycle process multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development system development developmental process plasma membrane bounded cell projection organization nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development actin cytoskeleton organization cortical actin cytoskeleton organization cortical cytoskeleton organization actin filament-based process secretion by cell exocytosis secretion export from cell establishment or maintenance of bipolar cell polarity establishment or maintenance of epithelial cell apical/basal polarity establishment or maintenance of apical/basal cell polarity	cell periphery cellular anatomical structure plasma membrane membrane intracellular anatomical structure cytoplasm membrane-bounded organelle Golgi apparatus subcompartment Golgi apparatus organelle subcompartment Golgi cisterna intracellular membrane-bounded organelle endomembrane system intracellular organelle cell periphery cellular anatomical structure plasma membrane membrane intracellular anatomical structure cytoplasm membrane-bounded organelle Golgi apparatus subcompartment Golgi apparatus organelle subcompartment Golgi cisterna intracellular membrane-bounded organelle endomembrane system intracellular organelle Golgi cis cisterna organelle Golgi stack cell-cell junction adherens junction anchoring junction cell junction cytoskeleton membraneless organelle intracellular membraneless organelle cell cortex cortical cytoskeleton actin cytoskeleton cortical actin cytoskeleton Golgi membrane bounding membrane of organelle organelle membrane endosome membrane early endosome endosome intracellular vesicle early endosome membrane cytoplasmic vesicle membrane cytoplasmic vesicle vesicle membrane vesicle trans-Golgi network membrane trans-Golgi network axon cell projection neuron projection plasma membrane bounded cell projection
A [auth I]	Protein kinase C iota type	binding phospholipid binding lipid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding binding phospholipid binding lipid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups cation binding metal ion binding protein serine/threonine kinase activity diacylglycerol-dependent serine/threonine kinase activity protein serine kinase activity	regulation of postsynaptic membrane neurotransmitter receptor levels biological regulation regulation of biological quality positive regulation of protein localization to plasma membrane protein localization regulation of localization cellular localization regulation of cellular process regulation of protein localization positive regulation of biological process localization cellular macromolecule localization regulation of protein localization to membrane positive regulation of cellular process regulation of postsynaptic membrane neurotransmitter receptor levels biological regulation regulation of biological quality positive regulation of protein localization to plasma membrane protein localization regulation of localization cellular localization regulation of cellular process regulation of protein localization positive regulation of biological process localization cellular macromolecule localization regulation of protein localization to membrane positive regulation of cellular process positive regulation of protein localization to cell periphery regulation of biological process protein localization to cell periphery protein localization to plasma membrane positive regulation of protein localization to membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane regulation of cellular localization macromolecule localization positive regulation of protein localization cellular process regulation of protein localization to plasma membrane establishment of protein localization establishment of protein localization to membrane protein targeting establishment of localization protein targeting to membrane cell migration cell motility regulation of neuron projection development multicellular organismal process regulation of cellular component organization positive regulation of cellular component organization cellular developmental process cell projection organization cell development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation positive regulation of neuron projection development cell differentiation anatomical structure development positive regulation of cell projection organization cellular component organization or biogenesis system development developmental process plasma membrane bounded cell projection organization regulation of cell projection organization nervous system development generation of neurons neuron development regulation of plasma membrane bounded cell projection organization organelle organization cytoskeleton organization positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of molecular function regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process protein phosphorylation phosphorylation macromolecule modification phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process transport vesicle-mediated transport regulation of glial cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death negative regulation of glial cell apoptotic process cell death glial cell apoptotic process negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death actin cytoskeleton organization actin filament organization actin filament-based process supramolecular fiber organization secretion membrane organization vesicle budding from membrane Golgi vesicle budding vesicle organization Golgi vesicle transport response to peptide response to stimulus response to chemical response to cytokine response to interleukin-1 sensory organ development photoreceptor cell differentiation visual system development eye morphogenesis eye photoreceptor cell differentiation animal organ morphogenesis sensory system development photoreceptor cell development eye photoreceptor cell development eye development animal organ development anatomical structure morphogenesis sensory organ morphogenesis neuron apoptotic process negative regulation of neuron apoptotic process regulation of neuron apoptotic process establishment of cell polarity establishment or maintenance of bipolar cell polarity establishment of monopolar cell polarity establishment or maintenance of monopolar cell polarity establishment of apical/basal cell polarity establishment or maintenance of apical/basal cell polarity establishment or maintenance of cell polarity positive regulation of endothelial cell apoptotic process positive regulation of programmed cell death positive regulation of apoptotic process endothelial cell apoptotic process regulation of endothelial cell apoptotic process cellular response to nitrogen compound cellular response to stimulus response to endogenous stimulus response to peptide hormone response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to insulin cellular response to insulin stimulus cellular response to hormone stimulus cellular response to stress response to stress cellular response to chemical stress positive regulation of cell communication positive regulation of signal transduction signaling regulation of signal transduction cell communication positive regulation of response to stimulus signal transduction regulation of signaling cell surface receptor signaling pathway Notch signaling pathway regulation of response to stimulus regulation of Notch signaling pathway regulation of cell communication positive regulation of Notch signaling pathway positive regulation of signaling intracellular signal transduction positive regulation of nervous system development regulation of developmental process positive regulation of cell population proliferation regulation of neurogenesis regulation of cell differentiation regulation of gliogenesis positive regulation of glial cell proliferation positive regulation of gliogenesis regulation of cell development regulation of nervous system development positive regulation of developmental process regulation of glial cell proliferation gliogenesis positive regulation of cell differentiation regulation of multicellular organismal process positive regulation of neurogenesis regulation of multicellular organismal development cell population proliferation positive regulation of cell development regulation of cell population proliferation positive regulation of multicellular organismal process glial cell proliferation hexose transmembrane transport D-glucose import carbohydrate transport positive regulation of D-glucose transmembrane transport positive regulation of transmembrane transport regulation of D-glucose import positive regulation of D-glucose import regulation of transport transmembrane transport regulation of transmembrane transport positive regulation of transport D-glucose transmembrane transport regulation of D-glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport cell junction organization cell-cell junction organization establishment or maintenance of epithelial cell apical/basal polarity	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cell leading edge extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cell leading edge cluster of actin-based cell projections brush border synapse cell junction glutamatergic synapse protein kinase complex transferase complex, transferring phosphorus-containing groups PAR polarity complex protein-containing complex catalytic complex serine/threonine protein kinase complex transferase complex intercellular bridge Golgi membrane Golgi apparatus membrane intracellular membrane-bounded organelle endomembrane system intracellular organelle bounding membrane of organelle organelle membrane cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen cytoskeleton membraneless organelle intracellular membraneless organelle microtubule cytoskeleton compact myelin myelin sheath Schmidt-Lanterman incisure endosome intracellular vesicle cytoplasmic vesicle Schaffer collateral - CA1 synapse cell-cell junction apical junction complex bicellular tight junction tight junction anchoring junction
C [auth P]	Partitioning defective 6 homolog alpha	small GTPase binding protein binding binding enzyme binding GTPase binding GTP-dependent protein binding	viral process cellular process cell division regulation of localization localization regulation of biological process cellular localization regulation of cellular process regulation of cellular localization biological regulation regulation of protein modification process regulation of protein phosphorylation negative regulation of biological process negative regulation of phosphate metabolic process viral process cellular process cell division regulation of localization localization regulation of biological process cellular localization regulation of cellular process regulation of cellular localization biological regulation regulation of protein modification process regulation of protein phosphorylation negative regulation of biological process negative regulation of phosphate metabolic process regulation of primary metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process negative regulation of cellular process protein metabolic process protein modification process phosphorus metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process metabolic process regulation of phosphorylation regulation of phosphorus metabolic process macromolecule metabolic process negative regulation of phosphorylation regulation of metabolic process protein localization establishment of protein localization nitrogen compound transport regulation of protein localization transport positive regulation of biological process positive regulation of establishment of protein localization positive regulation of secretion by cell protein localization to extracellular region positive regulation of protein transport regulation of secretion by cell secretion by cell positive regulation of secretion cellular macromolecule localization positive regulation of cellular process regulation of transport secretion regulation of establishment of protein localization establishment of protein localization to extracellular region export from cell regulation of protein transport protein secretion establishment of localization positive regulation of protein secretion regulation of protein secretion regulation of secretion positive regulation of transport protein transport macromolecule localization positive regulation of protein localization microtubule organizing center organization microtubule cytoskeleton organization cellular component organization organelle organization centrosome cycle microtubule-based process cell cycle cellular component organization or biogenesis cytoskeleton organization cell cycle process establishment or maintenance of cell polarity cell junction maintenance cell junction organization cellular component maintenance cell-cell junction maintenance cell-cell junction organization protein localization to microtubule cytoskeleton regulation of protein localization to centrosome protein localization to microtubule organizing center protein localization to cytoskeleton protein localization to organelle positive regulation of protein localization to centrosome protein localization to centrosome establishment or maintenance of bipolar cell polarity establishment or maintenance of epithelial cell apical/basal polarity establishment or maintenance of apical/basal cell polarity	cell periphery cell cortex cellular anatomical structure intracellular anatomical structure cytoplasm apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane intracellular organelle centrosome microtubule organizing center cytoskeleton cell periphery cell cortex cellular anatomical structure intracellular anatomical structure cytoplasm apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane intracellular organelle centrosome microtubule organizing center cytoskeleton organelle membraneless organelle intracellular membraneless organelle microtubule cytoskeleton centriolar satellite cytosol protein kinase complex transferase complex, transferring phosphorus-containing groups PAR polarity complex protein-containing complex catalytic complex serine/threonine protein kinase complex transferase complex ruffle cell projection cell leading edge plasma membrane bounded cell projection cell-cell junction apical junction complex bicellular tight junction tight junction anchoring junction cell junction membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth L]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
B [auth L]	IPR000664	Lethal(2) giant larvae protein	Family
B [auth L]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
B [auth L]	IPR013577	Lethal giant larvae homologue 2	Domain
B [auth L]	IPR001680	WD40 repeat	Repeat
A [auth I]	IPR012233	Protein kinase C	Family
A [auth I]	IPR020454	Diacylglycerol/phorbol-ester binding	Domain
A [auth I]	IPR034661	Atypical protein kinase C iota type, catalytic domain	Domain
A [auth I]	IPR000719	Protein kinase domain	Domain
A [auth I]	IPR017892	Protein kinase, C-terminal	Domain
A [auth I]	IPR053793	PB1-like domain	Domain
A [auth I]	IPR017441	Protein kinase, ATP binding site	Binding Site
A [auth I]	IPR000270	PB1 domain	Domain
A [auth I]	IPR000961	AGC-kinase, C-terminal	Domain
A [auth I]	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	Domain
A [auth I]	IPR034877	Protein kinase C, PB1 domain	Domain
A [auth I]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A [auth I]	IPR046349	C1-like domain superfamily	Homologous Superfamily
A [auth I]	IPR008271	Serine/threonine-protein kinase, active site	Active Site
C [auth P]	IPR000270	PB1 domain	Domain
C [auth P]	IPR051741	Partitioning defective 6 homolog protein	Family
C [auth P]	IPR034868	Partitioning defective protein 6, PB1 domain	Domain
C [auth P]	IPR036034	PDZ superfamily	Homologous Superfamily
C [auth P]	IPR053793	PB1-like domain	Domain
C [auth P]	IPR001478	PDZ domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B [auth L]	Pharos: Q15334	breast carcinoma attention deficit hyperactivity disorder, inattentive type large cell medulloblastoma Malignant neoplasm of breast medulloblastoma psoriasis breast cancer lymphoplasmacytic lymphoma osteosarcoma Sjogren syndrome malignant ependymoma ovarian cancer skin basal cell carcinoma
A [auth I]	Pharos: P41743	bipolar disorder glioblastoma malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm psoriasis cancer lung adenocarcinoma Mental Depression pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia tuberculosis depressive disorder malignant glioma metastatic melanoma bipolar disorder glioblastoma malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm psoriasis cancer lung adenocarcinoma Mental Depression pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia tuberculosis depressive disorder malignant glioma metastatic melanoma pancreatic intraductal papillary-mucinous carcinoma prostate carcinoma
C [auth P]	Pharos: Q9NPB6	astrocytic tumor large cell medulloblastoma pilocytic astrocytoma atypical teratoid rhabdoid tumor malignant ependymoma subependymal giant cell astrocytoma glioblastoma malignant glioma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B [auth L]	SEP	Parent Component: SER RESID: AA0037 PSI-MOD : O-phospho-L-serine MOD:00046
A [auth I]	TPO	Parent Component: THR RESID: AA0037 , AA0038 PSI-MOD : O-phospho-L-serine MOD:00046 , O-phospho-L-threonine MOD:00047