8UZ2

E. coli acetyl-CoA carboxylase, narrow helical local reconstruction, 3.18 Angstrom

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B, F	Biotin carboxyl carrier protein of acetyl-CoA carboxylase	CoA carboxylase activity acetyl-CoA carboxylase activity ligase activity, forming carbon-carbon bonds catalytic activity ligase activity molecular adaptor activity	fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process small molecule metabolic process metabolic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process small molecule metabolic process metabolic process cellular process monocarboxylic acid metabolic process lipid metabolic process malonyl-CoA metabolic process thioester biosynthetic process nucleobase-containing compound metabolic process acyl-CoA metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process acyl-CoA biosynthetic process malonyl-CoA biosynthetic process phosphate-containing compound metabolic process sulfur compound metabolic process amide metabolic process thioester metabolic process phosphorus metabolic process nucleoside phosphate metabolic process amide biosynthetic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process sulfur compound biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol acetyl-CoA carboxylase complex protein-containing complex catalytic complex
C, G	Biotin carboxylase	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding CoA carboxylase activity acetyl-CoA carboxylase activity ligase activity, forming carbon-carbon bonds catalytic activity ligase activity identical protein binding protein binding protein homodimerization activity protein dimerization activity biotin carboxylase activity ligase activity, forming carbon-nitrogen bonds cation binding metal ion binding	fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process small molecule metabolic process metabolic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process small molecule metabolic process metabolic process cellular process monocarboxylic acid metabolic process lipid metabolic process malonyl-CoA metabolic process thioester biosynthetic process nucleobase-containing compound metabolic process acyl-CoA metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process acyl-CoA biosynthetic process malonyl-CoA biosynthetic process phosphate-containing compound metabolic process sulfur compound metabolic process amide metabolic process thioester metabolic process phosphorus metabolic process nucleoside phosphate metabolic process amide biosynthetic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process sulfur compound biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process regulation of cellular process negative regulation of small molecule metabolic process ketone metabolic process regulation of lipid metabolic process negative regulation of biological process negative regulation of lipid biosynthetic process regulation of primary metabolic process regulation of small molecule metabolic process negative regulation of cellular process negative regulation of fatty acid biosynthetic process regulation of biosynthetic process regulation of biological process negative regulation of fatty acid metabolic process negative regulation of metabolic process biological regulation regulation of ketone metabolic process negative regulation of biosynthetic process regulation of fatty acid metabolic process regulation of fatty acid biosynthetic process regulation of lipid biosynthetic process regulation of metabolic process negative regulation of lipid metabolic process	acetyl-CoA carboxylase complex protein-containing complex cellular anatomical structure intracellular anatomical structure catalytic complex cytoplasm cytosol
D, H, I	Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding CoA carboxylase activity acetyl-CoA carboxylase activity ligase activity, forming carbon-carbon bonds catalytic activity ligase activity RNA binding mRNA binding carboxyl- or carbamoyltransferase activity transferase activity, transferring one-carbon groups transferase activity cation binding transition metal ion binding zinc ion binding metal ion binding	regulation of cellular process negative regulation of biological process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process regulation of protein metabolic process negative regulation of metabolic process biological regulation regulation of cellular process negative regulation of biological process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process regulation of protein metabolic process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process regulation of translation negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process carboxylic acid metabolic process lipid biosynthetic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process small molecule metabolic process monocarboxylic acid metabolic process lipid metabolic process malonyl-CoA metabolic process thioester biosynthetic process nucleobase-containing compound metabolic process acyl-CoA metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process acyl-CoA biosynthetic process malonyl-CoA biosynthetic process phosphate-containing compound metabolic process sulfur compound metabolic process amide metabolic process thioester metabolic process phosphorus metabolic process nucleoside phosphate metabolic process amide biosynthetic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process sulfur compound biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process long-chain fatty acid metabolic process long-chain fatty acid biosynthetic process	protein-containing complex acetyl-CoA carboxylase complex cellular anatomical structure intracellular anatomical structure catalytic complex transferase complex cytoplasm acetate CoA-transferase complex cytosol
A, E	Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding CoA carboxylase activity acetyl-CoA carboxylase activity ligase activity, forming carbon-carbon bonds catalytic activity ligase activity carboxyl- or carbamoyltransferase activity transferase activity, transferring one-carbon groups transferase activity identical protein binding protein binding	fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process small molecule metabolic process metabolic process fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process small molecule metabolic process metabolic process cellular process monocarboxylic acid metabolic process lipid metabolic process malonyl-CoA metabolic process thioester biosynthetic process nucleobase-containing compound metabolic process acyl-CoA metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process acyl-CoA biosynthetic process malonyl-CoA biosynthetic process phosphate-containing compound metabolic process sulfur compound metabolic process amide metabolic process thioester metabolic process phosphorus metabolic process nucleoside phosphate metabolic process amide biosynthetic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process sulfur compound biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process long-chain fatty acid metabolic process long-chain fatty acid biosynthetic process	protein-containing complex acetyl-CoA carboxylase complex cellular anatomical structure intracellular anatomical structure catalytic complex transferase complex cytoplasm acetate CoA-transferase complex cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B, F	IPR001249	Acetyl-CoA biotin carboxyl carrier	Family
B, F	IPR050709	Biotin Carboxyl Carrier/Decarboxylase Components	Family
B, F	IPR011053	Single hybrid motif	Homologous Superfamily
B, F	IPR001882	Biotin-binding site	Binding Site
B, F	IPR000089	Biotin/lipoyl attachment	Domain
C, G	IPR005481	Biotin carboxylase-like, N-terminal domain	Domain
C, G	IPR011761	ATP-grasp fold	Domain
C, G	IPR011764	Biotin carboxylation domain	Domain
C, G	IPR051602	Acetyl-CoA Carboxylase Biotin Carboxylase Component	Family
C, G	IPR013815	ATP-grasp fold, subdomain 1	Homologous Superfamily
C, G	IPR004549	Acetyl-CoA carboxylase, biotin carboxylase	Family
C, G	IPR005482	Biotin carboxylase, C-terminal	Domain
C, G	IPR005479	Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain	Domain
C, G	IPR016185	Pre-ATP-grasp domain superfamily	Homologous Superfamily
C, G	IPR011054	Rudiment single hybrid motif	Homologous Superfamily
D, H, I	IPR029045	ClpP/crotonase-like domain superfamily	Homologous Superfamily
D, H, I	IPR011762	Acetyl-coenzyme A carboxyltransferase, N-terminal	Domain
D, H, I	IPR000438	Acetyl-CoA carboxylase carboxyl transferase, beta subunit	Family
D, H, I	IPR041010	Acetyl-coA carboxylase zinc finger domain	Domain
D, H, I	IPR034733	Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta	Domain
A, E	IPR011763	Acetyl-coenzyme A carboxyltransferase, C-terminal	Domain
A, E	IPR029045	ClpP/crotonase-like domain superfamily	Homologous Superfamily
A, E	IPR001095	Acetyl-CoA carboxylase, alpha subunit	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.

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8UZ2

E. coli acetyl-CoA carboxylase, narrow helical local reconstruction, 3.18 Angstrom

External Resource: Annotation

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage