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BERENIL


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Chemical Component Summary

NameBERENIL
SynonymsDIMINAZINE ACETURATE; 1,3-TRIS-(4'AMIDINOPHENYL)TRIAZINE
Identifiers4-[(2E)-2-(4-carbamimidoylphenyl)iminohydrazinyl]benzenecarboximidamide
FormulaC14 H15 N7
Molecular Weight281.316
TypeNON-POLYMER
Isomeric SMILESc1cc(ccc1C(=N)N)N/N=N/c2ccc(cc2)C(=N)N
InChIInChI=1S/C14H15N7/c15-13(16)9-1-5-11(6-2-9)19-21-20-12-7-3-10(4-8-12)14(17)18/h1-8H,(H3,15,16)(H3,17,18)(H,19,20)
InChIKeyXNYZHCFCZNMTFY-UHFFFAOYSA-N

Chemical Details

Formal Charge0
Atom Count36
Chiral Atom Count0
Bond Count37
Aromatic Bond Count12

Drug Info: DrugBank

DrugBank IDDB03608 
NameDiminazene
Groups experimental
DescriptionDiminazene, also known as Diminazine, 4,4'-(Diazoamino)benzamidine, 4,4'-(1-triazene-1,3-diyl)bis-benzenecarboximidamide, diminazine aceturate, or Diminazene aceturate, is a trypanocidal agent. Major brands of Diminazene are Berenil, Pirocide, Ganasag, and Azidin. This substance is a solid. This compound belongs to the phenylhydrazines. These are compounds containing a phenylhydrazide moiety, which consists of a hydrazide substituent attached to a phenyl group. Known drug targets of diminazene include HTH-type transcriptional regulator QacR, trypsin-1, amiloride-sensitive amine oxidase [copper-containing], and mitochondrial peroxiredoxin-5.
Synonyms
  • 4,4'-(diazoamino)benzamidine
  • Diminazene
  • 4,4'-(1-triazene-1,3-diyl)bis-benzenecarboximidamide
  • Diminazeno
  • Diminazène
Categories
  • Amidines
  • Anti-Infective Agents
  • Antiparasitic Agents
  • Antiprotozoals
  • Benzamidines
CAS number536-71-0

Drug Targets

NameTarget SequencePharmacological ActionActions
HTH-type transcriptional regulator QacRMNLKDKILGVAKELFIKNGYNATTTGEIVKLSESSKGNLYYHFKTKENLF...unknown
Trypsin-1MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGG...unknown
Amiloride-sensitive amine oxidase [copper-containing]MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWS...unknown
Peroxiredoxin-5, mitochondrialMGLAGVCALRRSAGYILVGGAGGQSAAAAARRYSEGEWASGGVRSFSRAA...unknown
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
Pharos CHEMBL35241
PubChem 2354
ChEMBL CHEMBL35241
ChEBI CHEBI:81724