Chemical Component Summary

NameMIMOSINE
Synonyms3-HYDROXY-4-OXO-1(4H)-PYRIDINEALANINE
Identifiers(2S)-2-amino-3-(3-hydroxy-4-oxo-pyridin-1-yl)propanoic acid
FormulaC8 H10 N2 O4
Molecular Weight198.176
TypeNON-POLYMER
Isomeric SMILESC1=CN(C=C(C1=O)O)C[C@@H](C(=O)O)N
InChIInChI=1S/C8H10N2O4/c9-5(8(13)14)3-10-2-1-6(11)7(12)4-10/h1-2,4-5,12H,3,9H2,(H,13,14)/t5-/m0/s1
InChIKeyWZNJWVWKTVETCG-YFKPBYRVSA-N

Chemical Details

Formal Charge0
Atom Count24
Chiral Atom Count1
Bond Count24
Aromatic Bond Count6

Drug Info: DrugBank

DrugBank IDDB01055 
NameMimosine
Groups experimental
DescriptionMimosine is an antineoplastic alanine-substituted pyridine derivative isolated from _Leucena glauca_.
Synonyms
  • Mimosine
  • Leucenol
  • Leucaenol
  • Leucenine
  • (S)-2-amino-3-(3-hydroxy-4-oxo-4H-pyridin-1-yl)propanoate
Categories
  • Alanine
  • Amino Acids
  • Amino Acids, Peptides, and Proteins
  • Pyridines
  • Pyridones
CAS number500-44-7

Drug Targets

NameTarget SequencePharmacological ActionActions
Serine hydroxymethyltransferase, cytosolicMTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLEL...unknowninhibitor
C-C motif chemokine 2MKVSAALLCLLLIAATFIPQGLAQPDAINAPVTCCYNFTNRKISVQRLAS...unknowninhibitor
TyrosinaseMLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLS...unknowninhibitor
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource NameReference
PubChem 440473, 6971294
ChEMBL CHEMBL245416
ChEBI CHEBI:29063, CHEBI:77689, CHEBI:77848