Download MendeleyA new kinase docking system for RSK AGC kinase domain
Alexa, A., Sok, P., Remenyi, A.To be published.
8R58
The RSK 2 N-terminal kinase domain in complex with BMF (1-19)
- PDB DOI: https://doi.org/10.2210/pdb8R58/pdb
- Classification: SIGNALING PROTEIN
- Organism(s): Homo sapiens
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): No
- Deposited: 2023-11-16 Released: 2024-11-27
- Funding Organization(s): Hungarian National Research, Development and Innovation Office
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.31 Å
- R-Value Free: 0.263
- R-Value Work: 0.235
- R-Value Observed: 0.238
Starting Model: experimental
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This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Ribosomal protein S6 kinase alpha-3 | 317 | Homo sapiens | Mutation(s): 0 Gene Names: RPS6KA3, ISPK1, MAPKAPK1B, RSK2 EC: 2.7.11.1 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P51812 (Homo sapiens) Explore P51812 Go to UniProtKB: P51812 | |||||
PHAROS: P51812 GTEx: ENSG00000177189 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P51812 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by: Sequence | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Bcl-2-modifying factor | 19 | Homo sapiens | Mutation(s): 0 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q96LC9 (Homo sapiens) Explore Q96LC9 Go to UniProtKB: Q96LC9 | |||||
PHAROS: Q96LC9 GTEx: ENSG00000104081 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q96LC9 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| QCT Query on QCT | C [auth A] | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside C21 H20 O11 OXGUCUVFOIWWQJ-HQBVPOQASA-N |  | ||
| GOL Query on GOL | D [auth A] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.31 Å
- R-Value Free: 0.263
- R-Value Work: 0.235
- R-Value Observed: 0.238
- Space Group: P 21 21 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 82.309 | α = 90 |
| b = 88.256 | β = 90 |
| c = 39.21 | γ = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| STARANISO | data scaling |
| XDS | data reduction |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2024-11-27 Deposition Author(s): Sok, P., Remenyi, A.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Hungarian National Research, Development and Innovation Office | Hungary | KKP 126963 |
Revision History (Full details and data files)
- Version 1.0: 2024-11-27
Type: Initial release
