Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
A [auth D]SCOP2B SuperfamilyTrypsin-like serine proteases 8035341 3000114 SCOP2B (2022-06-29)
B [auth F]SCOP2B SuperfamilyEGF/Laminin-like 8035338 3000412 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth D]Trypsine1c5mD1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: FMN-binding split barrel 2F: TrypsinECOD (1.6)
B [auth F]FXa_inhibitione1c5mF1 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: EGF/LamininF: FXa_inhibitionECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A [auth D]2.40.10.10 Mainly Beta Beta Barrel Thrombin, subunit H Trypsin-like serine proteasesCATH (4.3.0)
B [auth F]2.10.25.10 Mainly Beta Ribbon Laminin LamininCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A [auth D]PF00089Trypsin (Trypsin)Trypsin- Domain
B [auth F]PF14670Coagulation Factor Xa inhibitory site (FXa_inhibition)Coagulation Factor Xa inhibitory siteThis short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442 [1].Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth D]PROTEIN (COAGULATION FACTOR X)
B [auth F]PROTEIN (COAGULATION FACTOR X)

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A [auth D]IPR000294Gamma-carboxyglutamic acid-rich (GLA) domainDomain
A [auth D]IPR018097EGF-like calcium-binding, conserved siteConserved Site
A [auth D]IPR000742EGF-like domainDomain
A [auth D]IPR018114Serine proteases, trypsin family, histidine active siteActive Site
A [auth D]IPR050442Peptidase S1 family, coagulation factorsFamily
A [auth D]IPR009003Peptidase S1, PA clanHomologous Superfamily
A [auth D]IPR017857Coagulation factor-like, Gla domain superfamilyHomologous Superfamily
A [auth D]IPR001314Peptidase S1A, chymotrypsin familyFamily
A [auth D]IPR033116Serine proteases, trypsin family, serine active siteActive Site
A [auth D]IPR001254Serine proteases, trypsin domainDomain
A [auth D]IPR035972Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyHomologous Superfamily
A [auth D]IPR001881EGF-like calcium-binding domainDomain
A [auth D]IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
A [auth D]IPR000152EGF-type aspartate/asparagine hydroxylation sitePTM
A [auth D]IPR012224Peptidase S1A, coagulation factor VII/IX/X/C/ZFamily
B [auth F]IPR000294Gamma-carboxyglutamic acid-rich (GLA) domainDomain
B [auth F]IPR018097EGF-like calcium-binding, conserved siteConserved Site
B [auth F]IPR000742EGF-like domainDomain
B [auth F]IPR018114Serine proteases, trypsin family, histidine active siteActive Site
B [auth F]IPR050442Peptidase S1 family, coagulation factorsFamily
B [auth F]IPR009003Peptidase S1, PA clanHomologous Superfamily
B [auth F]IPR017857Coagulation factor-like, Gla domain superfamilyHomologous Superfamily
B [auth F]IPR001314Peptidase S1A, chymotrypsin familyFamily
B [auth F]IPR033116Serine proteases, trypsin family, serine active siteActive Site
B [auth F]IPR001254Serine proteases, trypsin domainDomain
B [auth F]IPR035972Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyHomologous Superfamily
B [auth F]IPR001881EGF-like calcium-binding domainDomain
B [auth F]IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
B [auth F]IPR000152EGF-type aspartate/asparagine hydroxylation sitePTM
B [auth F]IPR012224Peptidase S1A, coagulation factor VII/IX/X/C/ZFamily