1.9A STRUCTURE OF THE THERAPEUTIC ANTIBODY CAMPATH-1H FAB IN COMPLEX WITH A SYNTHETIC PEPTIDE ANTIGEN
External Resource: Annotation
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
B [auth H] | SCOP2B Superfamily | Immunoglobulin (Ig) domain-like | 8055393 | 3000071 | SCOP2B (2022-06-29) |
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
A [auth L] | C1-set_4 | e1ce1L2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_4 | ECOD (1.6) |
A [auth L] | V-set | e1ce1L1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set | ECOD (1.6) |
B [auth H] | V-set_8 | e1ce1H1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
B [auth H] | C1-set_1 | e1ce1H2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_1 | ECOD (1.6) |
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
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A [auth L] | CAMPATH-1H | L-KAPPA | Humanized (humanized) | IGKV1-33*01, IGKV1D-33*01, IGKJ1*01, IGKC*01 | V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA | IG | FAB-GAMMA-1_KAPPA | IMGT (202444-0) |
B [auth H] | CAMPATH-1H | VH-CH1 | Humanized (humanized) | IGHV4-59*04, IGHJ4*01, IGHJ4*02, IGHJ4*03, IGHG1*01, IGHG1*02, IGHG1*04, IGHG1*05 | V-DOMAIN VH, C-DOMAIN CH1 | IG | FAB-GAMMA-1_KAPPA | IMGT (202444-0) |
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
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A [auth L] | Light Chain | IGKV1 | Kappa | protein (peptide antigen) | SAbDab (2024-11-08) |
B [auth H] | Heavy Chain | IGHV4 | - | protein (peptide antigen) | SAbDab (2024-11-08) |
Chains | Polymer | Molecular Function | Biological Process | Cellular Component |
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A [auth L] | PROTEIN (CAMPATH-1H:LIGHT CHAIN) | - | - | - |
B [auth H] | PROTEIN (CAMPATH-1H:HEAVY CHAIN) | - | | |
C [auth P] | PROTEIN (PEPTIDE ANTIGEN) | - | - | - |