1D2S

CRYSTAL STRUCTURE OF THE N-TERMINAL LAMININ G-LIKE DOMAIN OF SHBG IN COMPLEX WITH DIHYDROTESTOSTERONE

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1d2sa_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Laminin G-like module	Sex hormone-binding globulin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8043043	3000120	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Laminin_G_1	e1d2sA1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Laminin_G_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00054	Laminin G domain (Laminin_G_1)	Laminin G domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	SEX HORMONE-BINDING GLOBULIN	binding hormone binding androgen binding organic cyclic compound binding steroid binding lipid binding	-	cellular anatomical structure extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A	IPR001791	Laminin G domain	Domain
A	IPR051145	Growth Arrest-Specific/Sex Hormone-Binding/Vitamin K-Dependent	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P04278	metabolic syndrome X type 2 diabetes mellitus erectile dysfunction prostate cancer uterine corpus leiomyoma Neoplasm Invasiveness alcohol abuse aspiration pneumonitis tinea corporis proctitis Hodgkins lymphoma atopic eczema dermatitis herpetiformis hyperandrogenism triple-negative breast carcinoma metabolic syndrome X type 2 diabetes mellitus erectile dysfunction prostate cancer uterine corpus leiomyoma Neoplasm Invasiveness alcohol abuse aspiration pneumonitis tinea corporis proctitis Hodgkins lymphoma atopic eczema dermatitis herpetiformis hyperandrogenism triple-negative breast carcinoma psoriatic arthritis hypogonadotropic hypogonadism autoimmune thrombocytopenic purpura acne rheumatic heart disease IgA glomerulonephritis mycosis fungoides acquired thrombocytopenia sarcoidosis infertility disorder breast fibrocystic disease neuroblastoma otitis externa adrenocortical insufficiency skin basal cell carcinoma iridocyclitis chronic beryllium disease eye disease amenorrhea juvenile idiopathic arthritis contact dermatitis corneal ulcer granuloma annulare anovulation tenosynovitis cryptorchidism asthma tinea pedis maturity-onset diabetes of the young atrial fibrillation dermatophytosis of groin and perianal area Diamond-Blackfan anemia hyperinsulinism autoimmune disease hypopituitarism multiple sclerosis rheumatoid arthritis inborn carbohydrate metabolic disorder blepharoconjunctivitis endometriosis acute lymphoblastic leukemia bursitis pemphigus erythema multiforme inherited aplastic anemia polycystic ovary syndrome esophageal squamous cell carcinoma skin disease iritis synovitis keratitis glioblastoma angioedema systemic lupus erythematosus primary cutaneous T-cell lymphoma hemorrhoid aphthous stomatitis thyroiditis cutaneous melanoma primary ovarian failure atopic conjunctivitis melanoma trichinosis psoriasis hypogonadism autoimmune hemolytic anemia ulcerative colitis miliary tuberculosis idiopathic acute eosinophilic pneumonia uveitis musculoskeletal system disease endometrial carcinoma acquired hyperprolactinemia rosacea brain glioma nephrotic syndrome epicondylitis Addison disease seborrheic dermatitis inflammatory bowel disease obesity disorder physiological sexual disorder exanthem allergic rhinitis congenital adrenal hyperplasia postmenopausal osteoporosis Klinefelter syndrome gout ankylosing spondylitis tendinitis Crohn disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.