Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyProtein prenylyltransferase 8026255 4001331 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyProtein prenylyltransferase 8038634 3001312 SCOP2 (2022-06-29)
BSCOP2 FamilyProtein prenyltransferases 8026028 4001193 SCOP2 (2022-06-29)
BSCOP2 SuperfamilyTerpenoid cyclases/Protein prenyltransferases 8038407 3001024 SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APPTAe1d8dA1 A: alpha superhelicesX: Repetitive alpha hairpinsH: ARM repeat (From Topology)T: ARM repeatF: PPTAECOD (1.6)
BSQHop_cyclase_Ce1d8dB1 A: alpha superhelicesX: Repetitive alpha hairpinsH: alpha/alpha toroid (From Topology)T: alpha/alpha toroidF: SQHop_cyclase_CECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A1.25.40.120 Mainly Alpha Alpha Horseshoe Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat Protein prenylyltransferaseCATH (4.3.0)
B1.50.10.20 Mainly Alpha Alpha/alpha barrel Glycosyltransferase CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF01239Protein prenyltransferase alpha subunit repeat (PPTA)Protein prenyltransferase alpha subunit repeat- Repeat
PF00432Prenyltransferase and squalene oxidase repeat (Prenyltrans)Prenyltransferase and squalene oxidase repeat- Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
farnesyltransferase (alpha subunit)
farnesyltransferase (beta subunit)
C [auth P]K-RAS4B PEPTIDE SUBSTRATE

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
C [auth P]PharosP01116

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
A, B
protein farnesyltransferase  M-CSA #484

Farnesyltransferase (FTase) is an important zinc metalloenzyme that is responsible for the specific transfer of a 15 carbon isoprenoid farnesyl from farnesyldiphosphate (FPP) to peptide substrates containing a characteristic carboxy-terminal CAAX motif. Within the motif, C is the cysteine that is farnesylated, 'A' represents an aliphatic residue and X is the terminal residue, normally methionine, serine, alanine or glutamine. Much research has been carried out on FTase since the group of substrate peptides it farnesylates includes the Ras family of proteins, the oncogenic forms of which are implicated in cell transformation.

Defined by 10 residues: LYS:A-164HIS:B-248ARG:B-291LYS:B-294ASP:B-297CYS:B-299TYR:B-300ASP:B-352ASP:B-359HIS:B-362
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