Annotations: 1DRO

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1droa_	All beta proteins	PH domain-like barrel	PH domain-like	Pleckstrin-homology domain (PH domain)	beta-spectrin	fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Pleckstrin-homology domain (PH domain)	8030175	4002395	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PH domain-like	8042554	3000134	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PH	e1droA1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PH	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00169	PH domain (PH)	PH domain	PH stands for pleckstrin homology.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	BETA-SPECTRIN	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding ankyrin binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding ankyrin binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding microtubule binding tubulin binding calmodulin binding structural constituent of cytoskeleton structural molecule activity	neuron recognition multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development axon choice point recognition cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron recognition multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development axon choice point recognition cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development cell recognition cellular component organization or biogenesis system development developmental process plasma membrane bounded cell projection organization axon midline choice point recognition axon guidance nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron projection guidance neuron development cellular process regulation of biological process regulation of cellular component organization regulation of cellular process biological regulation regulation of synapse organization cell junction organization regulation of synapse structure or activity synapse organization regulation of biological quality organelle organization actin cytoskeleton organization actin filament-based process cytoskeleton organization trans-synaptic signaling signaling cell-cell signaling chemical synaptic transmission cell communication synaptic signaling anterograde trans-synaptic signaling neuromuscular synaptic transmission regulation of cellular component size negative regulation of biological process protein-containing complex disassembly regulation of protein-containing complex disassembly actin filament depolymerization regulation of actin filament depolymerization cellular component biogenesis actin filament capping cellular component assembly negative regulation of supramolecular fiber organization negative regulation of actin filament polymerization cellular component disassembly negative regulation of cellular component organization actin filament organization regulation of organelle organization negative regulation of protein depolymerization negative regulation of protein-containing complex assembly regulation of protein polymerization regulation of supramolecular fiber organization supramolecular fiber organization regulation of cytoskeleton organization regulation of actin filament-based process regulation of protein-containing complex assembly negative regulation of protein-containing complex disassembly negative regulation of cellular process protein-containing complex assembly negative regulation of protein polymerization regulation of actin filament polymerization actin polymerization or depolymerization protein polymerization regulation of actin filament organization actin filament polymerization protein-containing complex organization regulation of protein depolymerization negative regulation of cytoskeleton organization regulation of actin polymerization or depolymerization regulation of cellular component biogenesis negative regulation of organelle organization regulation of actin filament length regulation of actin cytoskeleton organization negative regulation of actin filament depolymerization protein depolymerization regulation of anatomical structure size maintenance of synapse structure cell junction maintenance maintenance of presynaptic active zone structure cellular component maintenance presynaptic active zone organization membrane organization regulation of plasma membrane organization plasma membrane organization endomembrane system organization photoreceptor cell axon guidance regulation of microtubule polymerization or depolymerization negative regulation of microtubule depolymerization microtubule cytoskeleton organization microtubule polymerization or depolymerization regulation of microtubule depolymerization negative regulation of microtubule polymerization or depolymerization regulation of microtubule-based process microtubule depolymerization microtubule-based process regulation of microtubule cytoskeleton organization positive regulation of cell communication regulation of growth developmental growth long-term strengthening of neuromuscular junction neuromuscular junction development regulation of synaptic assembly at neuromuscular junction regulation of neuromuscular junction development positive regulation of synaptic transmission regulation of cell junction assembly regulation of trans-synaptic signaling synapse assembly regulation of developmental process modulation of chemical synaptic transmission positive regulation of biological process cell junction assembly regulation of synapse assembly positive regulation of cellular process regulation of signaling regulation of developmental growth growth synaptic assembly at neuromuscular junction regulation of cell communication positive regulation of signaling	cell junction cellular anatomical entity intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle spectrosome cytoplasm non-membrane-bounded organelle cell periphery plasma membrane membrane neuromuscular junction synapse cell junction cellular anatomical entity intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle spectrosome cytoplasm non-membrane-bounded organelle cell periphery plasma membrane membrane neuromuscular junction synapse spectrin protein-containing complex cell cortex cortical cytoskeleton actin cytoskeleton cytoskeleton cortical actin cytoskeleton axon cell projection neuron projection plasma membrane bounded cell projection lateral plasma membrane fusome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001849	Pleckstrin homology domain	Domain
A	IPR001605	Pleckstrin homology domain, spectrin-type	Domain
A	IPR041681	Pleckstrin homology domain 9	Domain
A	IPR001715	Calponin homology domain	Domain
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR001589	Actinin-type actin-binding domain, conserved site	Conserved Site
A	IPR036872	CH domain superfamily	Homologous Superfamily
A	IPR018159	Spectrin/alpha-actinin	Repeat
A	IPR016343	Spectrin, beta subunit	Family
A	IPR002017	Spectrin repeat	Repeat

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.