Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyRas-binding domain, RBD 8022105 4000380 SCOP2 (2022-06-29)
ASCOP2 FamilyPhoshoinositide 3-kinase (PI3K), catalytic domain 8024294 4002173 SCOP2 (2022-06-29)
ASCOP2 FamilyPhoshoinositide 3-kinase (PI3K) helical domain 8026216 4001302 SCOP2 (2022-06-29)
ASCOP2 FamilyPLC-like (P variant) 8028335 4002218 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyUbiquitin-like 8034485 3000157 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyProtein kinase-like (PK-like) 8036673 3000066 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyARM repeat-like 8038595 3000116 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyC2 domain (calcium/lipid-binding domain, calb) 8040714 3000965 SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
API3K_C2e1e7uA1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: C2 domain (From Topology)T: C2 domainF: PI3K_C2ECOD (1.6)
API3Kae1e7uA2 A: alpha superhelicesX: Repetitive alpha hairpinsH: ARM repeat (From Topology)T: ARM repeatF: PI3KaECOD (1.6)
API3K_rbde1e7uA3 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: PI3K_rbdECOD (1.6)
API3_PI4_kinasee1e7uA4 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: PI3_PI4_kinaseECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00613Phosphoinositide 3-kinase family, accessory domain (PIK domain) (PI3Ka)Phosphoinositide 3-kinase family, accessory domain (PIK domain)- Repeat
PF00792Phosphoinositide 3-kinase C2 (PI3K_C2)Phosphoinositide 3-kinase C2Phosphoinositide 3-kinase region postulated to contain a C2 domain. Outlier of Pfam:PF00168 family.Domain
PF00794PI3-kinase family, ras-binding domain (PI3K_rbd)PI3-kinase family, ras-binding domainCertain members of the PI3K family possess Ras-binding domains in their N-termini. These regions show some similarity (although not highly significant similarity) to Ras-binding Pfam:PF00788 domains (unpublished observation).Domain
PF00454Phosphatidylinositol 3- and 4-kinase (PI3_PI4_kinase)Phosphatidylinositol 3- and 4-kinase- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT

Membrane Protein Annotation: OPM OPM Database Homepage

ChainsExternal LinkTypeClassSuperfamilyFamily
OPMPhosphatidylinositol 3- and 4-kinase