Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1e8ca2 Alpha and beta proteins (a/b) MurD-like peptide ligases, peptide-binding domain MurD-like peptide ligases, peptide-binding domain MurCDEF C-terminal domain UDP-N-acetylmuramyl tripeptide synthetase MurE (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Ad1e8ca3 Alpha and beta proteins (a/b) Ribokinase-like MurD-like peptide ligases, catalytic domain MurCDEF UDP-N-acetylmuramyl tripeptide synthetase MurE (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Ad1e8ca1 Alpha and beta proteins (a/b) MurF and HprK N-domain-like MurE/MurF N-terminal domain MurE/MurF N-terminal domain UDP-N-acetylmuramyl tripeptide synthetase MurE (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Ad1e8ca4 Artifacts Tags Tags Tags C-terminal Tags (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Bd1e8cb2 Alpha and beta proteins (a/b) MurD-like peptide ligases, peptide-binding domain MurD-like peptide ligases, peptide-binding domain MurCDEF C-terminal domain UDP-N-acetylmuramyl tripeptide synthetase MurE (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Bd1e8cb3 Alpha and beta proteins (a/b) Ribokinase-like MurD-like peptide ligases, catalytic domain MurCDEF UDP-N-acetylmuramyl tripeptide synthetase MurE (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Bd1e8cb1 Alpha and beta proteins (a/b) MurF and HprK N-domain-like MurE/MurF N-terminal domain MurE/MurF N-terminal domain UDP-N-acetylmuramyl tripeptide synthetase MurE (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Bd1e8cb4 Artifacts Tags Tags Tags C-terminal Tags (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyMurD catalytic domain-like 8003704 3000107 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyMurD peptide-binding domain-like 8091453 3001290 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyMurE/MurF N-terminal domain 8003715 3000146 SCOP2B (2022-06-29)
BSCOP2 FamilyMurEF 8003702 4000234 SCOP2 (2022-06-29)
BSCOP2 SuperfamilyMurD catalytic domain-like 8003704 3000107 SCOP2 (2022-06-29)
BSCOP2 SuperfamilyMurE/MurF N-terminal domain 8003715 3000146 SCOP2 (2022-06-29)
BSCOP2 SuperfamilyMurD peptide-binding domain-like 8091453 3001290 SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AMur_ligase_Me1e8cA1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: Mur_ligase_MECOD (1.6)
AMur_ligase_1e1e8cA3 A: a/b three-layered sandwichesX: MurF and HprK N-domain-like (From Topology)H: MurF and HprK N-domain-like (From Topology)T: MurF and HprK N-domain-likeF: Mur_ligase_1ECOD (1.6)
AMur_ligase_Ce1e8cA2 A: a/b three-layered sandwichesX: MurD-like peptide ligases, peptide-binding domain (From Topology)H: MurD-like peptide ligases, peptide-binding domain (From Topology)T: MurD-like peptide ligases, peptide-binding domainF: Mur_ligase_CECOD (1.6)
BMur_ligase_Me1e8cB1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: Mur_ligase_MECOD (1.6)
BMur_ligase_1e1e8cB3 A: a/b three-layered sandwichesX: MurF and HprK N-domain-like (From Topology)H: MurF and HprK N-domain-like (From Topology)T: MurF and HprK N-domain-likeF: Mur_ligase_1ECOD (1.6)
BMur_ligase_Ce1e8cB2 A: a/b three-layered sandwichesX: MurD-like peptide ligases, peptide-binding domain (From Topology)H: MurD-like peptide ligases, peptide-binding domain (From Topology)T: MurD-like peptide ligases, peptide-binding domainF: Mur_ligase_CECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF08245Mur ligase middle domain (Mur_ligase_M)Mur ligase middle domain- Domain
A, B
PF01225Mur ligase family, catalytic domain (Mur_ligase)Mur ligase family, catalytic domainThis family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC (Swiss:P17952), MurD (Swiss:P14900), MurE (Swiss:P22188), MurF (Swiss:P11880), Mpl (Swiss:P37773) and FolC (Swiss:P08192). MurC, MurD, ...This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC (Swiss:P17952), MurD (Swiss:P14900), MurE (Swiss:P22188), MurF (Swiss:P11880), Mpl (Swiss:P37773) and FolC (Swiss:P08192). MurC, MurD, Mure and MurF catalyse consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesised by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Domain
A, B
PF02875Mur ligase, glutamate ligase domain (Mur_ligase_C)Mur ligase, glutamate ligase domainThis entry contains a number of related ligase enzymes which have EC numbers 6.3.2.* which includes: MurC (Swiss:P17952), MurD (Swiss:P14900), MurE (Swiss:P22188), MurF (Swiss:P11880), Mpl (Swiss:P37773) and FolC (Swiss:P08192). MurC, MurD, MurE and ...This entry contains a number of related ligase enzymes which have EC numbers 6.3.2.* which includes: MurC (Swiss:P17952), MurD (Swiss:P14900), MurE (Swiss:P22188), MurF (Swiss:P11880), Mpl (Swiss:P37773) and FolC (Swiss:P08192). MurC, MurD, MurE and MurF catalyse consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesised by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine [1,3,4]. This entry also includes folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate and cyanophycin synthetase that catalyses the biosynthesis of the cyanobacterial reserve material multi-L-arginyl-poly-L-aspartate (cyanophycin) [2].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMATE--2,6-DIAMINOPIMELATE LIGASE