1EWF

THE 1.7 ANGSTROM CRYSTAL STRUCTURE OF BPI

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ewfa1	Alpha and beta proteins (a+b)	Aha1/BPI domain-like	Bactericidal permeability-increasing protein, BPI	Bactericidal permeability-increasing protein, BPI	Bactericidal permeability-increasing protein, BPI	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Bactericidal permeability-increasing protein, BPI	8022812	4001570	SCOP2 (2022-06-29)
A	SCOP2 Family	Bactericidal permeability-increasing protein, BPI	8022815	4001570	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Aha1/BPI domain-like	8035192	3001851	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Aha1/BPI domain-like	8035195	3001851	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	LBP_BPI_CETP	e1ewfA1	A: a+b complex topology	X: Aha1/BPI domain-like (From Topology)	H: Aha1/BPI domain-like (From Topology)	T: Aha1/BPI domain-like	F: LBP_BPI_CETP	ECOD (1.6)
A	LBP_BPI_CETP_C	e1ewfA2	A: a+b complex topology	X: Aha1/BPI domain-like (From Topology)	H: Aha1/BPI domain-like (From Topology)	T: Aha1/BPI domain-like	F: LBP_BPI_CETP_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.15.10.10	Alpha Beta	Super Roll	Bactericidal permeability-increasing protein	domain 1	CATH (4.3.0)
A	3.15.20.10	Alpha Beta	Super Roll	Bactericidal permeability-increasing protein	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01273	LBP / BPI / CETP family, N-terminal domain (LBP_BPI_CETP)	LBP / BPI / CETP family, N-terminal domain	-	Family
A	PF02886	LBP / BPI / CETP family, C-terminal domain (LBP_BPI_CETP_C)	LBP / BPI / CETP family, C-terminal domain	The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	BACTERICIDAL/PERMEABILITY-INCREASING PROTEIN	binding lipid binding lipopolysaccharide binding carbohydrate derivative binding	multicellular organismal process regulation of tumor necrosis factor production regulation of cellular process negative regulation of biological process negative regulation of tumor necrosis factor production cytokine production regulation of cytokine production negative regulation of cellular process regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process negative regulation of metabolic process biological regulation multicellular organismal process regulation of tumor necrosis factor production regulation of cellular process negative regulation of biological process negative regulation of tumor necrosis factor production cytokine production regulation of cytokine production negative regulation of cellular process regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process negative regulation of metabolic process biological regulation tumor necrosis factor superfamily cytokine production negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process tumor necrosis factor production regulation of gene expression negative regulation of gene expression regulation of tumor necrosis factor superfamily cytokine production biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of tumor necrosis factor superfamily cytokine production metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process interleukin-6 production regulation of interleukin-6 production negative regulation of interleukin-6 production biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus defense response to Gram-negative bacterium response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus negative regulation of interleukin-8 production interleukin-8 production regulation of interleukin-8 production cellular response to stimulus response to lipid signaling cellular response to lipopolysaccharide cell communication lipopolysaccharide-mediated signaling pathway cellular response to biotic stimulus signal transduction cell surface receptor signaling pathway response to oxygen-containing compound cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical cellular response to lipid response to molecule of bacterial origin immune response defense response to symbiont immune system process innate immune response regulation of macrophage activation regulation of leukocyte activation cell activation regulation of cell activation myeloid leukocyte activation leukocyte activation negative regulation of cell activation macrophage activation negative regulation of immune system process regulation of immune system process negative regulation of leukocyte activation negative regulation of macrophage activation	cellular anatomical structure membrane extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle cellular anatomical structure membrane extracellular region extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle vesicle lumen intracellular anatomical structure intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen intracellular membrane-bounded organelle secretory granule lumen endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen specific granule lumen secretory granule secretory vesicle cytoplasm specific granule lytic vacuole vacuolar lumen lysosome azurophil granule vacuole azurophil granule lumen primary lysosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR017943	Bactericidal permeability-increasing protein, alpha/beta domain superfamily	Homologous Superfamily
A	IPR017942	Lipid-binding serum glycoprotein, N-terminal	Domain
A	IPR017954	Lipid-binding serum glycoprotein, conserved site	Conserved Site
A	IPR032942	BPI/LBP/Plunc family	Family
A	IPR001124	Lipid-binding serum glycoprotein, C-terminal	Domain
A	IPR030675	Lipid binding protein BPI/LBP	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P17213	MALT lymphoma osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.