1EXB

STRUCTURE OF THE CYTOPLASMIC BETA SUBUNIT-T1 ASSEMBLY OF VOLTAGE-DEPENDENT K CHANNELS

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1exba_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	NAD(P)-linked oxidoreductase	Aldo-keto reductases (NADP)	Voltage-dependent K+ channel beta subunit	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)
B [auth E]	d1exbe_	Alpha and beta proteins (a+b)	POZ domain	POZ domain	Tetramerization domain of potassium channels	KV1.1	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	NAD(P)-linked oxidoreductase	8040991	3000288	SCOP2B (2022-06-29)
B [auth E]	SCOP2 Family	Tetramerization domain of potassium channels	8022649	4001137	SCOP2 (2022-06-29)
B [auth E]	SCOP2 Superfamily	POZ domain	8035029	3000894	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Aldo_ket_red	e1exbA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Aldo_ket_red	ECOD (1.6)
B [auth E]	BTB_2	e1exbE1	A: a+b two layers	X: POZ domain (From Topology)	H: POZ domain (From Topology)	T: POZ domain	F: BTB_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.20.100	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	NADP-dependent oxidoreductase domain	CATH (4.3.0)
B [auth E]	3.30.710.10	Alpha Beta	2-Layer Sandwich	Potassium Channel Kv1.1	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00248	Aldo/keto reductase family (Aldo_ket_red)	Aldo/keto reductase family	This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity [2].	Domain
B [auth E]	PF02214	BTB/POZ domain (BTB_2)	BTB/POZ domain	In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels [1]. In KCTD1 (Swiss:Q719H9) this domain functions as a transcriptional repressor [2]. It also mediates homo ...	In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels [1]. In KCTD1 (Swiss:Q719H9) this domain functions as a transcriptional repressor [2]. It also mediates homomultimerisation of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha [2-3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	KV BETA2 PROTEIN	methylglyoxal reductase (NADPH) (acetol producing) activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors catalytic activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity methylglyoxal reductase (NADPH) (acetol producing) activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors catalytic activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity voltage-gated potassium channel activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity protein binding binding transmembrane transporter binding aldo-keto reductase (NADPH) activity alcohol dehydrogenase [NAD(P)+] activity protein-containing complex binding potassium channel regulator activity channel regulator activity ion channel regulator activity molecular function regulator activity transporter regulator activity	developmental process muscle structure development cellular developmental process cell differentiation anatomical structure development cellular process myoblast differentiation protein localization regulation of localization cellular localization regulation of biological process regulation of cellular process regulation of protein localization biological regulation developmental process muscle structure development cellular developmental process cell differentiation anatomical structure development cellular process myoblast differentiation protein localization regulation of localization cellular localization regulation of biological process regulation of cellular process regulation of protein localization biological regulation localization protein localization to cell surface regulation of cellular localization cellular macromolecule localization macromolecule localization regulation of protein localization to cell surface regulation of action potential action potential regulation of biological quality regulation of membrane potential nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process NADP metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process metabolic process small molecule metabolic process NADPH oxidation phosphorus metabolic process pyridine nucleotide metabolic process multicellular organismal process system process nervous system process neuromuscular process regulation of potassium ion transport transport monoatomic ion transmembrane transport potassium ion transmembrane transport regulation of monoatomic ion transmembrane transport metal ion transport monoatomic cation transmembrane transport monoatomic ion transport monoatomic cation transport regulation of metal ion transport regulation of transport regulation of monoatomic ion transport inorganic ion transmembrane transport regulation of potassium ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport regulation of transmembrane transport potassium ion transport regulation of monoatomic cation transmembrane transport hemopoiesis cell development hematopoietic progenitor cell differentiation	postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse cellular anatomical structure neuron to neuron synapse organelle cell junction postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse cellular anatomical structure neuron to neuron synapse organelle cell junction postsynaptic membrane asymmetric synapse plasma membrane region axon cell projection main axon juxtaparanode region of axon neuron projection plasma membrane bounded cell projection intracellular anatomical structure cytoplasm cytosol axon initial segment glutamatergic synapse voltage-gated potassium channel complex protein-containing complex plasma membrane protein complex potassium channel complex membrane protein complex cation channel complex transporter complex transmembrane transporter complex monoatomic ion channel complex intracellular organelle cytoskeleton membraneless organelle intracellular membraneless organelle pinceau fiber axon terminus presynapse distal axon neuron projection terminus cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane
B [auth E]	POTASSIUM CHANNEL KV1.1	monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity voltage-gated potassium channel activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity voltage-gated potassium channel activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity delayed rectifier potassium channel activity voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential disordered domain specific binding protein binding binding protein domain specific binding	developmental process neuroblast proliferation multicellular organismal process cell population proliferation cellular developmental process nervous system development generation of neurons neurogenesis multicellular organism development cell differentiation anatomical structure development cellular process neural precursor cell proliferation system development developmental process neuroblast proliferation multicellular organismal process cell population proliferation cellular developmental process nervous system development generation of neurons neurogenesis multicellular organism development cell differentiation anatomical structure development cellular process neural precursor cell proliferation system development nerve development cranial nerve development optic nerve development head development central nervous system development animal organ development brain development transport monoatomic ion transmembrane transport potassium ion transmembrane transport inorganic ion transmembrane transport establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport potassium ion transport monoatomic cation transport protein localization cellular localization cellular macromolecule localization macromolecule localization plasma membrane bounded cell projection organization cell projection organization cell development neuron projection development axon development cellular component organization neuron differentiation neuron development cellular component organization or biogenesis system process nervous system process neuromuscular process membrane repolarization biological regulation action potential regulation of biological quality membrane repolarization during action potential regulation of membrane potential startle response response to stimulus response to external stimulus forebrain development pallium development cerebral cortex development telencephalon development detection of external stimulus response to mechanical stimulus detection of mechanical stimulus involved in sensory perception of touch sensory perception of touch detection of mechanical stimulus involved in sensory perception sensory perception of mechanical stimulus detection of abiotic stimulus detection of stimulus sensory perception detection of mechanical stimulus response to abiotic stimulus detection of stimulus involved in sensory perception cell communication by electrical coupling cell communication corpus callosum development hippocampus development limbic system development magnesium ion homeostasis inorganic ion homeostasis chemical homeostasis homeostatic process monoatomic ion homeostasis monoatomic cation homeostasis detection of stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain sensory perception of pain regulation of biological process regulation of muscle contraction regulation of system process regulation of multicellular organismal process muscle contraction regulation of muscle system process muscle system process transmission of nerve impulse neuronal action potential cellular response to stimulus cellular response to metal ion cellular response to chemical stimulus response to metal ion response to chemical response to magnesium ion cellular response to magnesium ion cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization neuronal signal transduction regulation of cellular process signaling signal transduction	cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane axon cell projection main axon juxtaparanode region of axon cell periphery postsynapse cellular anatomical structure postsynaptic membrane synapse cell junction membrane plasma membrane plasma membrane region synaptic membrane axon cell projection main axon juxtaparanode region of axon neuron projection plasma membrane bounded cell projection somatodendritic compartment cell body perikaryon neuronal cell body intracellular anatomical structure cytoplasm cytosol presynapse presynaptic membrane dendrite dendritic tree axon initial segment glutamatergic synapse protein-containing complex transmembrane transporter complex potassium channel complex membrane protein complex cation channel complex transporter complex monoatomic ion channel complex axon terminus distal axon calyx of Held neuron projection terminus paranode region of axon apical part of cell apical plasma membrane cell surface anchoring junction voltage-gated potassium channel complex plasma membrane protein complex membrane-bounded organelle intracellular organelle cytoplasmic vesicle organelle intracellular vesicle intracellular membrane-bounded organelle vesicle endoplasmic reticulum endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR005399	Potassium channel, voltage-dependent, beta subunit, KCNAB-related	Family
A	IPR036812	NADP-dependent oxidoreductase domain superfamily	Homologous Superfamily
A	IPR005401	Potassium channel, voltage-dependent, beta subunit, KCNAB2	Family
A	IPR023210	NADP-dependent oxidoreductase domain	Domain
A	IPR005983	Potassium channel, voltage-dependent, beta subunit, KCNAB	Family
B [auth E]	IPR003968	Potassium channel, voltage dependent, Kv	Family
B [auth E]	IPR004048	Potassium channel, voltage dependent, Kv1.1	Family
B [auth E]	IPR003131	Potassium channel tetramerisation-type BTB domain	Domain
B [auth E]	IPR011333	SKP1/BTB/POZ domain superfamily	Homologous Superfamily
B [auth E]	IPR003972	Potassium channel, voltage dependent, Kv1	Family
B [auth E]	IPR000210	BTB/POZ domain	Domain
B [auth E]	IPR005821	Ion transport domain	Domain
B [auth E]	IPR027359	Voltage-dependent channel domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.