Annotations: 1EZY

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ezya_	All alpha proteins	Regulator of G-protein signaling, RGS	Regulator of G-protein signaling, RGS	Regulator of G-protein signaling, RGS	Regulator of G-protein signaling 4, RGS4	Norway rat (Rattus norvegicus ) [TaxId: 10116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Regulator of G-protein signaling, RGS	8038096	3000835	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	RGS	e1ezyA1	A: alpha bundles	X: Regulator of G-protein signaling, RGS (From Topology)	H: Regulator of G-protein signaling, RGS (From Topology)	T: Regulator of G-protein signaling, RGS	F: RGS	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.196.10	Mainly Alpha	Orthogonal Bundle	Regulator of G-protein Signalling 4	domain 1	CATH (4.3.0)
A	1.10.167.10	Mainly Alpha	Orthogonal Bundle	Regulator of G-protein Signalling 4	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00615	Regulator of G protein signaling domain (RGS)	Regulator of G protein signaling domain	RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	REGULATOR OF G-PROTEIN SIGNALING 4	GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity protein binding binding kinase binding enzyme binding protein kinase binding G-protein alpha-subunit binding	heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation positive regulation of biological process positive regulation of heart rate positive regulation of blood circulation positive regulation of heart contraction circulatory system process regulation of blood circulation positive regulation of multicellular organismal process heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation positive regulation of biological process positive regulation of heart rate positive regulation of blood circulation positive regulation of heart contraction circulatory system process regulation of blood circulation positive regulation of multicellular organismal process regulation of multicellular organismal process regulation of biological quality heart contraction blood circulation regulation of heart rate regulation of localization import into cell negative regulation of amino acid transport regulation of cellular process nitrogen compound transport negative regulation of amine transport carboxylic acid transmembrane transport transport glycine transport negative regulation of biological process regulation of glycine import across plasma membrane amino acid transmembrane transport negative regulation of transport L-amino acid transport negative regulation of glycine import across plasma membrane negative regulation of transmembrane transport localization negative regulation of cellular process regulation of amino acid transport regulation of amino acid transmembrane transport organic acid transmembrane transport organic anion transport glycine import across plasma membrane carboxylic acid transport regulation of transport import across plasma membrane neutral amino acid transport establishment of localization organic cation transport organic acid transport transmembrane transport amino acid transport amine transport regulation of amino acid import across plasma membrane regulation of transmembrane transport negative regulation of organic acid transport regulation of organic acid transport L-alpha-amino acid transmembrane transport cellular process regulation of amine transport amino acid import across plasma membrane cellular response to stimulus positive regulation of cell communication regulation of postsynaptic membrane potential positive regulation of signal transduction response to stimulus signaling modulation of chemical synaptic transmission positive regulation of excitatory postsynaptic potential regulation of signal transduction chemical synaptic transmission, postsynaptic cell communication positive regulation of response to stimulus synaptic signaling modulation of excitatory postsynaptic potential signal transduction positive regulation of cellular process trans-synaptic signaling regulation of signaling cell surface receptor signaling pathway nervous system process cell-cell signaling chemical synaptic transmission regulation of nervous system process regulation of trans-synaptic signaling regulation of response to stimulus anterograde trans-synaptic signaling regulation of cell communication excitatory postsynaptic potential regulation of membrane potential positive regulation of signaling regulation of growth negative regulation of muscle hypertrophy regulation of cardiac muscle tissue growth developmental growth negative regulation of muscle cell differentiation regulation of cell differentiation muscle cell differentiation regulation of muscle hypertrophy muscle structure development multicellular organism development muscle adaptation negative regulation of growth cell differentiation regulation of organ growth regulation of heart growth anatomical structure development cardiac muscle tissue growth muscle tissue development cardiac cell development system development developmental process heart growth negative regulation of striated muscle cell differentiation negative regulation of cell growth striated muscle hypertrophy tissue development negative regulation of developmental growth regulation of muscle cell differentiation striated muscle cell differentiation negative regulation of multicellular organismal process regulation of cellular component organization regulation of developmental process cellular developmental process cardiac muscle cell development cell development negative regulation of cell growth involved in cardiac muscle cell development regulation of striated muscle cell differentiation negative regulation of cardiac muscle tissue growth organ growth cell growth striated muscle tissue development cellular component organization negative regulation of organ growth striated muscle cell development muscle cell development cardiac muscle hypertrophy negative regulation of cell differentiation cellular component organization or biogenesis muscle hypertrophy regulation of muscle adaptation heart development regulation of multicellular organismal development regulation of developmental growth negative regulation of heart growth cardiac muscle tissue development developmental cell growth physiological muscle hypertrophy negative regulation of developmental process growth animal organ development cardiac muscle cell differentiation regulation of cell growth involved in cardiac muscle cell development regulation of cell growth regulation of muscle system process muscle system process regulation of cardiac muscle hypertrophy cardiocyte differentiation circulatory system development cell growth involved in cardiac muscle cell development physiological cardiac muscle hypertrophy negative regulation of cardiac muscle hypertrophy regulation of calcium ion transport regulation of monoatomic ion transport metal ion transport calcium ion transport monoatomic ion transport regulation of metal ion transport monoatomic cation transport dorsal root ganglion development nervous system development ganglion development regulation of potassium ion transport monoatomic ion transmembrane transport negative regulation of monoatomic ion transport potassium ion transmembrane transport regulation of monoatomic ion transmembrane transport monoatomic cation transmembrane transport negative regulation of monoatomic ion transmembrane transport negative regulation of cation transmembrane transport negative regulation of potassium ion transport inorganic ion transmembrane transport negative regulation of potassium ion transmembrane transport regulation of potassium ion transmembrane transport inorganic cation transmembrane transport potassium ion transport regulation of monoatomic cation transmembrane transport regulation of cytoskeleton organization regulation of actin filament organization regulation of actin filament-based process actin cytoskeleton organization actin filament organization regulation of organelle organization organelle organization regulation of actin cytoskeleton organization actin filament-based process regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization response to alcohol response to chemical response to oxygen-containing compound response to ethanol cellular response to nitrogen compound response to dopamine negative regulation of signaling cellular response to dopamine response to monoamine regulation of dopamine receptor signaling pathway negative regulation of G protein-coupled receptor signaling pathway negative regulation of cell communication response to catecholamine cellular response to catecholamine stimulus regulation of G protein-coupled receptor signaling pathway response to organic cyclic compound negative regulation of response to stimulus negative regulation of dopamine receptor signaling pathway G protein-coupled dopamine receptor signaling pathway cellular response to organic cyclic compound response to nitrogen compound cellular response to oxygen-containing compound negative regulation of signal transduction cellular response to chemical stimulus cellular response to monoamine stimulus G protein-coupled receptor signaling pathway response to amine response to amphetamine response to cocaine response to alkaloid	cellular anatomical structure intracellular anatomical structure cytoplasm protein-containing complex membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR016137	RGS domain	Domain
A	IPR036305	RGS domain superfamily	Homologous Superfamily
A	IPR044926	RGS, subdomain 2	Homologous Superfamily
A	IPR034953	Regulator of G-protein signalling 4, RGS domain	Domain
A	IPR024066	RGS, subdomain 1/3	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.