Annotations: 1FIW

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth L]	d1fiw.1	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Eukaryotic proteases	Beta-acrosin	(Ovis aries ) [TaxId: 9940 ],	SCOPe (2.08)
A	d1fiw.1	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Eukaryotic proteases	Beta-acrosin	(Ovis aries ) [TaxId: 9940 ],	SCOPe (2.08)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00089	Trypsin (Trypsin)	Trypsin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B [auth L]	BETA-ACROSIN LIGHT CHAIN	binding D-mannose binding monosaccharide binding carbohydrate binding small molecule binding amidase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds fucose binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity binding D-mannose binding monosaccharide binding carbohydrate binding small molecule binding amidase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds fucose binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity serine-type endopeptidase activity endopeptidase activity	sexual reproduction acrosome reaction reproductive process fertilization single fertilization positive regulation of adenylate cyclase activity positive regulation of cyclase activity regulation of catalytic activity biological regulation positive regulation of catalytic activity positive regulation of molecular function regulation of molecular function regulation of lyase activity activation of adenylate cyclase activity sexual reproduction acrosome reaction reproductive process fertilization single fertilization positive regulation of adenylate cyclase activity positive regulation of cyclase activity regulation of catalytic activity biological regulation positive regulation of catalytic activity positive regulation of molecular function regulation of molecular function regulation of lyase activity activation of adenylate cyclase activity regulation of adenylate cyclase activity regulation of cyclase activity positive regulation of lyase activity proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	acrosomal vesicle membrane-bounded organelle intracellular anatomical structure intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle
A	BETA-ACROSIN HEAVY CHAIN	binding D-mannose binding monosaccharide binding carbohydrate binding small molecule binding amidase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds fucose binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity binding D-mannose binding monosaccharide binding carbohydrate binding small molecule binding amidase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds fucose binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity serine-type endopeptidase activity endopeptidase activity	sexual reproduction acrosome reaction reproductive process fertilization single fertilization positive regulation of adenylate cyclase activity positive regulation of cyclase activity regulation of catalytic activity biological regulation positive regulation of catalytic activity positive regulation of molecular function regulation of molecular function regulation of lyase activity activation of adenylate cyclase activity sexual reproduction acrosome reaction reproductive process fertilization single fertilization positive regulation of adenylate cyclase activity positive regulation of cyclase activity regulation of catalytic activity biological regulation positive regulation of catalytic activity positive regulation of molecular function regulation of molecular function regulation of lyase activity activation of adenylate cyclase activity regulation of adenylate cyclase activity regulation of cyclase activity positive regulation of lyase activity proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	acrosomal vesicle membrane-bounded organelle intracellular anatomical structure intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth L]	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
B [auth L]	IPR001314	Peptidase S1A, chymotrypsin family	Family
B [auth L]	IPR033116	Serine proteases, trypsin family, serine active site	Active Site
B [auth L]	IPR001254	Serine proteases, trypsin domain	Domain
B [auth L]	IPR012267	Peptidase S1A, acrosin	Family
B [auth L]	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
B [auth L]	IPR018114	Serine proteases, trypsin family, histidine active site	Active Site
A	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A	IPR001314	Peptidase S1A, chymotrypsin family	Family
A	IPR033116	Serine proteases, trypsin family, serine active site	Active Site
A	IPR001254	Serine proteases, trypsin domain	Domain
A	IPR012267	Peptidase S1A, acrosin	Family
A	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
A	IPR018114	Serine proteases, trypsin family, histidine active site	Active Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.