1FOE

CRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THE GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1foea1	All alpha proteins	DBL homology domain (DH-domain)	DBL homology domain (DH-domain)	DBL homology domain (DH-domain)	GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1)	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d1foea2	All beta proteins	PH domain-like barrel	PH domain-like	Pleckstrin-homology domain (PH domain)	GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1)	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
C	d1foec1	All alpha proteins	DBL homology domain (DH-domain)	DBL homology domain (DH-domain)	DBL homology domain (DH-domain)	GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1)	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
C	d1foec2	All beta proteins	PH domain-like barrel	PH domain-like	Pleckstrin-homology domain (PH domain)	GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1)	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
G	d1foeg1	All alpha proteins	DBL homology domain (DH-domain)	DBL homology domain (DH-domain)	DBL homology domain (DH-domain)	GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1)	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
G	d1foeg2	All beta proteins	PH domain-like barrel	PH domain-like	Pleckstrin-homology domain (PH domain)	GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1)	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
E	d1foee1	All alpha proteins	DBL homology domain (DH-domain)	DBL homology domain (DH-domain)	DBL homology domain (DH-domain)	GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1)	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
E	d1foee2	All beta proteins	PH domain-like barrel	PH domain-like	Pleckstrin-homology domain (PH domain)	GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1)	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d1foeb_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	Rac	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1foed_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	Rac	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d1foef_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	Rac	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d1foeh_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	Rac	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	DBL homology domain (DH-domain)	8025695	4001108	SCOP2 (2022-06-29)
A	SCOP2 Family	Pleckstrin-homology domain (PH domain)	8030190	4002395	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	DBL homology domain (DH-domain)	8038074	3000793	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PH domain-like	8042569	3000134	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	PH domain-like	8042569	3000134	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	DBL homology domain (DH-domain)	8038074	3000793	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	DBL homology domain (DH-domain)	8038074	3000793	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	PH domain-like	8042569	3000134	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	PH domain-like	8042569	3000134	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	DBL homology domain (DH-domain)	8038074	3000793	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Ras-like P-loop GTPases	8057406	3002022	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Ras-like P-loop GTPases	8057406	3002022	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Ras-like P-loop GTPases	8057406	3002022	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Ras-like P-loop GTPases	8057406	3002022	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PH_10	e1foeA1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PH_10	ECOD (1.6)
A	RhoGEF	e1foeA2	A: alpha bundles	X: DH domain-like	H: DBL homology domain (DH-domain) (From Topology)	T: DBL homology domain (DH-domain)	F: RhoGEF	ECOD (1.6)
C	PH_10	e1foeC1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PH_10	ECOD (1.6)
C	RhoGEF	e1foeC2	A: alpha bundles	X: DH domain-like	H: DBL homology domain (DH-domain) (From Topology)	T: DBL homology domain (DH-domain)	F: RhoGEF	ECOD (1.6)
G	PH_10	e1foeG1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PH_10	ECOD (1.6)
G	RhoGEF	e1foeG2	A: alpha bundles	X: DH domain-like	H: DBL homology domain (DH-domain) (From Topology)	T: DBL homology domain (DH-domain)	F: RhoGEF	ECOD (1.6)
E	PH_10	e1foeE1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PH_10	ECOD (1.6)
E	RhoGEF	e1foeE2	A: alpha bundles	X: DH domain-like	H: DBL homology domain (DH-domain) (From Topology)	T: DBL homology domain (DH-domain)	F: RhoGEF	ECOD (1.6)
B	Ras	e1foeB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Ras	ECOD (1.6)
D	Ras	e1foeD1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Ras	ECOD (1.6)
F	Ras	e1foeF1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Ras	ECOD (1.6)
H	Ras	e1foeH1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Ras	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.900.10	Mainly Alpha	Up-down Bundle	Dbl Homology Domain	Chain A	CATH (4.3.0)
A	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
C	1.20.900.10	Mainly Alpha	Up-down Bundle	Dbl Homology Domain	Chain A	CATH (4.3.0)
C	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
G	1.20.900.10	Mainly Alpha	Up-down Bundle	Dbl Homology Domain	Chain A	CATH (4.3.0)
G	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
E	1.20.900.10	Mainly Alpha	Up-down Bundle	Dbl Homology Domain	Chain A	CATH (4.3.0)
E	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
D	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
F	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
H	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G	PF00621	RhoGEF domain (RhoGEF)	RhoGEF domain	Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that Pfam:PF00169 domains invariably occur C-terminal to RhoGEF/DH domains.	Domain
B, D, F, H	PF00071	Ras family (Ras)	Ras family	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motil ...	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G	T-LYMPHOMA INVASION AND METASTASIS INDUCING PROTEIN 1	binding phospholipid binding lipid binding cytoskeletal protein binding microtubule binding protein binding tubulin binding signaling receptor binding ephrin receptor binding protein tyrosine kinase binding kinase binding receptor tyrosine kinase binding enzyme binding protein kinase binding binding phospholipid binding lipid binding cytoskeletal protein binding microtubule binding protein binding tubulin binding signaling receptor binding ephrin receptor binding protein tyrosine kinase binding kinase binding receptor tyrosine kinase binding enzyme binding protein kinase binding GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity	cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation cell surface receptor protein tyrosine kinase signaling pathway cell communication cellular process signal transduction enzyme-linked receptor protein signaling pathway ephrin receptor signaling pathway multicellular organismal process cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation cell surface receptor protein tyrosine kinase signaling pathway cell communication cellular process signal transduction enzyme-linked receptor protein signaling pathway ephrin receptor signaling pathway multicellular organismal process positive regulation of nervous system development axonogenesis cell projection organization regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell development positive regulation of developmental process multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development positive regulation of cell projection organization system development developmental process regulation of cell projection organization positive regulation of cell development nervous system development generation of neurons positive regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cellular developmental process regulation of developmental process plasma membrane bounded cell projection morphogenesis positive regulation of biological process cell development cell morphogenesis cellular component organization regulation of nervous system development neurogenesis positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis regulation of multicellular organismal process cellular component organization or biogenesis positive regulation of axonogenesis regulation of anatomical structure morphogenesis positive regulation of cellular process regulation of multicellular organismal development plasma membrane bounded cell projection organization axon development cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis neuron development regulation of plasma membrane bounded cell projection organization cell migration cell motility positive regulation of neuron projection development small GTPase-mediated signal transduction Rac protein signal transduction intracellular signal transduction intracellular signaling cassette regulation of signaling regulation of signal transduction regulation of MAPK cascade regulation of intracellular signal transduction regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade protein localization localization cellular localization cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane regulation of Wnt signaling pathway regulation of non-canonical Wnt signaling pathway non-canonical Wnt signaling pathway Wnt signaling pathway ligand-gated ion channel signaling pathway ionotropic glutamate receptor signaling pathway glutamate receptor signaling pathway NMDA selective glutamate receptor signaling pathway regulation of molecular function regulation of catalytic activity regulation of hydrolase activity regulation of GTPase activity postsynapse organization regulation of postsynapse organization regulation of synapse organization cell junction organization regulation of synapse structure or activity synapse organization regulation of biological quality positive regulation of dendritic spine morphogenesis positive regulation of dendritic spine development regulation of cell morphogenesis regulation of dendrite morphogenesis dendritic spine morphogenesis dendritic spine development dendritic spine organization positive regulation of cell morphogenesis regulation of dendrite development regulation of dendritic spine development dendrite development dendrite morphogenesis positive regulation of dendrite morphogenesis regulation of dendritic spine morphogenesis neuron projection organization cell adhesion cell-matrix adhesion cell-substrate adhesion brain-derived neurotrophic factor receptor signaling pathway dopaminergic neuron differentiation regulation of dopaminergic neuron differentiation regulation of neuron differentiation positive regulation of locomotion regulation of cell motility Schwann cell chemotaxis positive regulation of Schwann cell chemotaxis positive regulation of chemotaxis positive regulation of cell migration gliogenesis taxis chemotaxis regulation of Schwann cell chemotaxis response to external stimulus response to chemical regulation of locomotion regulation of response to external stimulus glial cell migration regulation of Schwann cell migration regulation of glial cell migration positive regulation of Schwann cell migration positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of cell motility regulation of cell migration locomotion cell chemotaxis regulation of chemotaxis Schwann cell migration positive regulation of glial cell migration cellular response to chemical stimulus developmental growth cell growth neuron projection extension developmental cell growth growth developmental growth involved in morphogenesis regulation of localization establishment of protein localization nitrogen compound transport carbohydrate homeostasis establishment of localization in cell regulation of peptide hormone secretion regulation of hormone levels establishment of protein localization to extracellular region intracellular glucose homeostasis protein secretion establishment of localization cellular response to oxygen-containing compound regulation of protein secretion regulation of secretion cellular response to carbohydrate stimulus chemical homeostasis response to glucose glucose homeostasis insulin secretion involved in cellular response to glucose stimulus regulation of hormone secretion regulation of protein localization regulation of peptide secretion transport homeostatic process hormone secretion protein localization to extracellular region peptide secretion secretion by cell regulation of secretion by cell response to monosaccharide response to carbohydrate amide transport signal release cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus secretion regulation of transport regulation of peptide transport regulation of establishment of protein localization cell-cell signaling export from cell response to oxygen-containing compound cellular response to glucose stimulus regulation of protein transport peptide transport response to hexose cellular homeostasis protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion regulation of insulin secretion involved in cellular response to glucose stimulus hormone transport insulin secretion muscle hypertrophy system process cardiac muscle hypertrophy striated muscle hypertrophy muscle system process activation of GTPase activity positive regulation of molecular function positive regulation of hydrolase activity positive regulation of catalytic activity positive regulation of GTPase activity regulation of modification of postsynaptic actin cytoskeleton regulation of modification of synaptic structure modification of postsynaptic actin cytoskeleton regulation of modification of postsynaptic structure modification of synaptic structure modification of postsynaptic structure	extrinsic component of plasma membrane postsynaptic specialization membrane synapse extrinsic component of postsynaptic density membrane postsynaptic density membrane cell periphery cellular anatomical structure cell junction extrinsic component of postsynaptic specialization membrane asymmetric synapse postsynaptic specialization membrane plasma membrane synaptic membrane extrinsic component of plasma membrane postsynaptic specialization membrane synapse extrinsic component of postsynaptic density membrane postsynaptic density membrane cell periphery cellular anatomical structure cell junction extrinsic component of postsynaptic specialization membrane asymmetric synapse postsynaptic specialization membrane plasma membrane synaptic membrane extrinsic component of synaptic membrane postsynapse postsynaptic density neuron to neuron synapse organelle postsynaptic membrane plasma membrane region extrinsic component of membrane extrinsic component of postsynaptic membrane cell-cell junction anchoring junction intracellular anatomical structure cytoplasm cytosol glutamatergic synapse membrane-bounded organelle 9+2 non-motile cilium non-motile cilium stereocilium bundle cilium neuron projection kinocilium cluster of actin-based cell projections plasma membrane bounded cell projection cell projection intracellular membraneless organelle pericentriolar material intracellular organelle centrosome microtubule organizing center cytoskeleton membraneless organelle microtubule cytoskeleton neuron spine dendritic spine somatodendritic compartment dendrite dendritic tree cell body neuronal cell body growth cone axon distal axon axonal growth cone site of polarized growth ruffle cell leading edge leading edge membrane ruffle membrane cell projection membrane cell-cell contact zone main axon
B, D, F, H	RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE	thioesterase binding protein binding binding enzyme binding protein-containing complex binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity Rho GDP-dissociation inhibitor binding GDP-dissociation inhibitor binding thioesterase binding protein binding binding enzyme binding protein-containing complex binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity Rho GDP-dissociation inhibitor binding GDP-dissociation inhibitor binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding kinase binding protein kinase binding G protein activity molecular function regulator activity	regulation of biological process regulation of cell motility regulation of cellular process regulation of leukocyte migration biological regulation neutrophil migration granulocyte migration leukocyte migration immune system process regulation of locomotion myeloid leukocyte migration regulation of cell migration cell migration cellular process regulation of biological process regulation of cell motility regulation of cellular process regulation of leukocyte migration biological regulation neutrophil migration granulocyte migration leukocyte migration immune system process regulation of locomotion myeloid leukocyte migration regulation of cell migration cell migration cellular process regulation of immune system process cell motility regulation of neutrophil migration locomotion lamellipodium assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cellular component organization cellular component biogenesis cellular component assembly lamellipodium organization cellular component organization or biogenesis cell projection assembly regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of cell adhesion positive regulation of biological process cell-substrate adhesion cell adhesion positive regulation of cell-substrate adhesion positive regulation of cellular process regulation of cellular component size regulation of biological quality regulation of cell size regulation of anatomical structure size substrate adhesion-dependent cell spreading multicellular organismal process negative regulation of biological process cytokine production regulation of cytokine production negative regulation of cellular process regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of metabolic process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process interleukin-23 production regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of interleukin-23 production negative regulation of multicellular organismal process regulation of metabolic process negative regulation of interleukin-23 production positive regulation of substrate adhesion-dependent cell spreading regulation of substrate adhesion-dependent cell spreading organelle organization actin cytoskeleton organization actin filament-based process cytoskeleton organization cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling cell surface receptor protein tyrosine kinase signaling pathway cell communication hepatocyte growth factor receptor signaling pathway signal transduction enzyme-linked receptor protein signaling pathway regulation of cellular component organization positive regulation of cellular component organization cell-substrate junction assembly positive regulation of cell-substrate junction organization cell junction assembly regulation of cell-substrate junction organization focal adhesion assembly positive regulation of focal adhesion assembly positive regulation of cellular component biogenesis positive regulation of cell-matrix adhesion regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly cell junction organization cell-matrix adhesion regulation of cell-matrix adhesion cell-substrate junction organization regulation of focal adhesion assembly regulation of cell-substrate junction assembly regulation of localization import into cell transport negative regulation of transport negative regulation of endocytosis vesicle-mediated transport localization regulation of endocytosis negative regulation of cellular component organization negative regulation of receptor-mediated endocytosis regulation of transport regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport establishment of localization endocytosis receptor-mediated endocytosis Wnt signaling pathway, planar cell polarity pathway non-canonical Wnt signaling pathway Wnt signaling pathway small GTPase-mediated signal transduction Rac protein signal transduction intracellular signal transduction intracellular signaling cassette cell chemotaxis chemotaxis response to external stimulus cellular response to chemical stimulus taxis response to chemical response to stress response to wounding establishment or maintenance of cell polarity ruffle organization positive regulation of organelle organization regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization microtubule cytoskeleton organization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly microtubule polymerization or depolymerization positive regulation of protein polymerization protein-containing complex assembly protein polymerization positive regulation of microtubule polymerization or depolymerization protein-containing complex organization positive regulation of cytoskeleton organization regulation of microtubule-based process microtubule polymerization positive regulation of supramolecular fiber organization regulation of organelle organization positive regulation of microtubule polymerization regulation of protein polymerization regulation of microtubule polymerization regulation of supramolecular fiber organization microtubule-based process supramolecular fiber organization regulation of microtubule cytoskeleton organization actin filament organization sphingolipid mediated signaling pathway sphingosine-1-phosphate receptor signaling pathway G protein-coupled receptor signaling pathway negative regulation of locomotion regulation of fibroblast migration fibroblast migration negative regulation of fibroblast migration ameboidal-type cell migration negative regulation of cell motility negative regulation of cell migration positive regulation of locomotion endothelial cell migration positive regulation of cell migration positive regulation of endothelial cell migration positive regulation of cell motility regulation of endothelial cell migration regulation of actin filament-based process regulation of actin filament bundle assembly actin filament bundle organization stress fiber assembly regulation of actin filament organization actomyosin structure organization regulation of stress fiber assembly contractile actin filament bundle assembly regulation of actomyosin structure organization actin filament bundle assembly regulation of actin cytoskeleton organization actin polymerization or depolymerization actin filament polymerization axonogenesis cellular developmental process motor neuron axon guidance plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development system development developmental process axon guidance nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron projection guidance neuron development positive regulation of cell communication positive regulation of signal transduction regulation of small GTPase mediated signal transduction regulation of signal transduction Rho protein signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction regulation of signaling positive regulation of intracellular signal transduction regulation of Rho protein signal transduction positive regulation of Rho protein signal transduction regulation of response to stimulus regulation of cell communication positive regulation of small GTPase mediated signal transduction positive regulation of signaling respiratory burst regulation of respiratory burst positive regulation of chemotaxis positive regulation of neutrophil chemotaxis positive regulation of immune system process regulation of leukocyte chemotaxis positive regulation of leukocyte chemotaxis positive regulation of granulocyte chemotaxis regulation of neutrophil chemotaxis regulation of response to external stimulus neutrophil chemotaxis regulation of granulocyte chemotaxis positive regulation of response to external stimulus positive regulation of leukocyte migration positive regulation of neutrophil migration regulation of chemotaxis granulocyte chemotaxis leukocyte chemotaxis regulation of hydrogen peroxide metabolic process reactive oxygen species metabolic process hydrogen peroxide metabolic process regulation of reactive oxygen species metabolic process regulation of nitric oxide biosynthetic process reactive nitrogen species metabolic process nitric oxide metabolic process nitric oxide biosynthetic process regulation of nitric oxide metabolic process regulation of developmental process regulation of cell shape regulation of cell morphogenesis regulation of anatomical structure morphogenesis cortical cytoskeleton organization semaphorin-plexin signaling pathway ruffle assembly positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation defense response inflammatory response cellular localization localization within membrane neuron migration regulation of cell projection organization regulation of cell projection assembly regulation of plasma membrane bounded cell projection assembly regulation of lamellipodium assembly regulation of lamellipodium organization regulation of plasma membrane bounded cell projection organization membrane organization engulfment of apoptotic cell phagocytosis, engulfment membrane invagination phagocytosis apoptotic cell clearance plasma membrane invagination positive regulation of cell projection organization positive regulation of lamellipodium assembly positive regulation of lamellipodium organization positive regulation of plasma membrane bounded cell projection assembly positive regulation of actin filament bundle assembly positive regulation of stress fiber assembly	cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol synapse cell junction glutamatergic synapse Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle endomembrane system intracellular organelle trans-Golgi network cytoskeleton membraneless organelle intracellular membraneless organelle neuron spine neuron projection dendritic spine somatodendritic compartment postsynapse dendrite dendritic tree anchoring junction focal adhesion cell-substrate junction pigment granule intracellular vesicle melanosome cytoplasmic vesicle cell periphery cell cortex ruffle plasma membrane leading edge membrane ruffle membrane plasma membrane region cell projection membrane protein-containing complex catalytic complex plasma membrane protein complex NADPH oxidase complex membrane protein complex oxidoreductase complex endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane cytoplasmic ribonucleoprotein granule supramolecular complex ribonucleoprotein granule endosome membrane endosome recycling endosome cytoplasmic vesicle membrane bounding membrane of organelle recycling endosome membrane vesicle membrane secretory granule secretory vesicle secretory granule membrane ficolin-1-rich granule membrane ficolin-1-rich granule tertiary granule nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G	IPR003116	Raf-like Ras-binding	Domain
A, C, E, G	IPR000219	Dbl homology (DH) domain	Domain
A, C, E, G	IPR040655	TIAM1, CC-Ex domain	Domain
A, C, E, G	IPR035899	Dbl homology (DH) domain superfamily	Homologous Superfamily
A, C, E, G	IPR001849	Pleckstrin homology domain	Domain
A, C, E, G	IPR011993	PH-like domain superfamily	Homologous Superfamily
A, C, E, G	IPR043537	Tiam1/Tiam2/Protein still life	Family
A, C, E, G	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	Conserved Site
A, C, E, G	IPR036034	PDZ superfamily	Homologous Superfamily
A, C, E, G	IPR001478	PDZ domain	Domain
B, D, F, H	IPR003578	Small GTPase Rho	Family
B, D, F, H	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B, D, F, H	IPR005225	Small GTP-binding domain	Domain
B, D, F, H	IPR001806	Small GTPase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B, D, F, H	Pharos: P63000	dilated cardiomyopathy melanoma Cardiotoxicity cutaneous melanoma congestive heart failure diabetes mellitus liver disease malignant glioma osteosarcoma plasma cell myeloma urinary bladder cancer heart disease hepatocellular carcinoma medulloblastoma ovarian cancer dilated cardiomyopathy melanoma Cardiotoxicity cutaneous melanoma congestive heart failure diabetes mellitus liver disease malignant glioma osteosarcoma plasma cell myeloma urinary bladder cancer heart disease hepatocellular carcinoma medulloblastoma ovarian cancer Sjogren syndrome depressive disorder dilated cardiomyopathy 1A heart failure intellectual disability lymphoplasmacytic lymphoma microcephaly pancreatic intraductal papillary-mucinous neoplasm intellectual disability, autosomal dominant 48

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D, E A, B, C, D, E, F, G, H	OPM	Monotopic/peripheral	All beta monotopic/peripheral	PH domain-like	Pleckstrin-homology domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.