1FQK

CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OF THE RGS DOMAIN OF RGS9, AND THE GT/I1 CHIMERA ALPHA SUBUNIT [(RGS9)-(GT/I1ALPHA)-(GDP)-(ALF4-)-(MG2+)]

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d1fqkc1	All alpha proteins	Transducin (alpha subunit), insertion domain	Transducin (alpha subunit), insertion domain	Transducin (alpha subunit), insertion domain	Transducin (alpha subunit), insertion domain	Bovine (Bos taurus ) [TaxId: 9913 ], Rat (Rattus norvegicus ) [TaxId: 10116 ], Bovine (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
C	d1fqkc2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	Transducin (alpha subunit)	Bovine (Bos taurus ) [TaxId: 9913 ], Rat (Rattus norvegicus ) [TaxId: 10116 ], Bovine (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
A	d1fqka1	All alpha proteins	Transducin (alpha subunit), insertion domain	Transducin (alpha subunit), insertion domain	Transducin (alpha subunit), insertion domain	Transducin (alpha subunit), insertion domain	Bovine (Bos taurus ) [TaxId: 9913 ], Rat (Rattus norvegicus ) [TaxId: 10116 ], Bovine (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
A	d1fqka2	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	Transducin (alpha subunit)	Bovine (Bos taurus ) [TaxId: 9913 ], Rat (Rattus norvegicus ) [TaxId: 10116 ], Bovine (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
B	d1fqkb_	All alpha proteins	Regulator of G-protein signaling, RGS	Regulator of G-protein signaling, RGS	Regulator of G-protein signaling, RGS	RGS9, RGS domain	Bovine (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)
D	d1fqkd_	All alpha proteins	Regulator of G-protein signaling, RGS	Regulator of G-protein signaling, RGS	Regulator of G-protein signaling, RGS	RGS9, RGS domain	Bovine (Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	Ras-like P-loop GTPases	8056788	3002022	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Galpha insert domain-like	8056789	3000669	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Galpha insert domain-like	8056789	3000669	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Ras-like P-loop GTPases	8056788	3002022	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Regulator of G-protein signaling, RGS	8038102	3000835	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Regulator of G-protein signaling, RGS	8038102	3000835	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	G-alpha	e1fqkC1	A: alpha arrays	X: Transducin (alpha subunit), insertion domain (From Topology)	H: Transducin (alpha subunit), insertion domain (From Topology)	T: Transducin (alpha subunit), insertion domain	F: G-alpha	ECOD (1.6)
C	Ras	e1fqkC2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Ras	ECOD (1.6)
A	G-alpha	e1fqkA1	A: alpha arrays	X: Transducin (alpha subunit), insertion domain (From Topology)	H: Transducin (alpha subunit), insertion domain (From Topology)	T: Transducin (alpha subunit), insertion domain	F: G-alpha	ECOD (1.6)
A	Ras	e1fqkA2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Ras	ECOD (1.6)
B	RGS	e1fqkB1	A: alpha bundles	X: Regulator of G-protein signaling, RGS (From Topology)	H: Regulator of G-protein signaling, RGS (From Topology)	T: Regulator of G-protein signaling, RGS	F: RGS	ECOD (1.6)
D	RGS	e1fqkD1	A: alpha bundles	X: Regulator of G-protein signaling, RGS (From Topology)	H: Regulator of G-protein signaling, RGS (From Topology)	T: Regulator of G-protein signaling, RGS	F: RGS	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
C	1.10.400.10	Mainly Alpha	Orthogonal Bundle	GI Alpha 1, domain 2-like	GI Alpha 1, domain 2-like	CATH (4.3.0)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
A	1.10.400.10	Mainly Alpha	Orthogonal Bundle	GI Alpha 1, domain 2-like	GI Alpha 1, domain 2-like	CATH (4.3.0)
B	1.10.196.10	Mainly Alpha	Orthogonal Bundle	Regulator of G-protein Signalling 4	domain 1	CATH (4.3.0)
B	1.10.167.10	Mainly Alpha	Orthogonal Bundle	Regulator of G-protein Signalling 4	domain 2	CATH (4.3.0)
D	1.10.196.10	Mainly Alpha	Orthogonal Bundle	Regulator of G-protein Signalling 4	domain 1	CATH (4.3.0)
D	1.10.167.10	Mainly Alpha	Orthogonal Bundle	Regulator of G-protein Signalling 4	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, D	PF00615	Regulator of G protein signaling domain (RGS)	Regulator of G protein signaling domain	RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Guanine nucleotide-binding protein G(t) subunit alpha-1,Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(t) subunit alpha-1	D2 dopamine receptor binding protein binding binding signaling receptor binding G protein-coupled receptor binding dopamine receptor binding GTPase activating protein binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding D2 dopamine receptor binding protein binding binding signaling receptor binding G protein-coupled receptor binding dopamine receptor binding GTPase activating protein binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cation binding magnesium ion binding metal ion binding GDP binding G protein-coupled serotonin receptor binding protein-containing complex binding G-protein beta/gamma-subunit complex binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity kinase binding enzyme binding protein kinase binding acyl binding	protein localization protein localization to postsynaptic specialization membrane cellular localization protein localization to postsynaptic membrane protein localization to cell periphery protein localization to synapse biological regulation localization within membrane protein localization to membrane protein-containing complex localization neurotransmitter receptor localization to postsynaptic specialization membrane localization regulation of postsynaptic membrane neurotransmitter receptor levels protein localization to organelle cellular macromolecule localization protein localization protein localization to postsynaptic specialization membrane cellular localization protein localization to postsynaptic membrane protein localization to cell periphery protein localization to synapse biological regulation localization within membrane protein localization to membrane protein-containing complex localization neurotransmitter receptor localization to postsynaptic specialization membrane localization regulation of postsynaptic membrane neurotransmitter receptor levels protein localization to organelle cellular macromolecule localization macromolecule localization cellular process protein localization to postsynapse regulation of biological quality protein localization to cell junction receptor localization to synapse cell division cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling cell communication adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction regulation of cytoskeleton organization regulation of cellular component organization microtubule cytoskeleton organization regulation of mitotic spindle organization mitotic cell cycle cellular component organization cell cycle cellular component organization or biogenesis regulation of cell cycle microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process regulation of cell cycle process regulation of microtubule-based process regulation of spindle organization regulation of organelle organization mitotic spindle organization organelle organization mitotic cell cycle process microtubule-based process cytoskeleton organization regulation of microtubule cytoskeleton organization positive regulation of protein localization to cell periphery regulation of localization regulation of protein localization positive regulation of biological process positive regulation of protein localization to cell cortex regulation of protein localization to cell periphery regulation of cellular localization regulation of protein localization to cell cortex positive regulation of protein localization protein localization to cell cortex positive regulation of cellular process trans-synaptic signaling regulation of signaling negative regulation of signaling modulation of chemical synaptic transmission negative regulation of biological process cell-cell signaling negative regulation of synaptic transmission negative regulation of cell communication chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling negative regulation of cellular process regulation of cell communication regulation of signal transduction intracellular signal transduction cAMP-mediated signaling regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette regulation of cAMP-mediated signaling response to ketone response to lipid response to alcohol cellular response to forskolin cellular response to organic cyclic compound response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to alcohol response to chemical response to forskolin cellular response to lipid cellular response to ketone response to organic cyclic compound detection of light stimulus involved in visual perception detection of light stimulus response to light stimulus multicellular organismal process detection of external stimulus sensory perception of light stimulus system process nervous system process response to external stimulus detection of abiotic stimulus detection of stimulus sensory perception detection of light stimulus involved in sensory perception response to abiotic stimulus response to radiation visual perception detection of stimulus involved in sensory perception phototransduction detection of visible light phototransduction, visible light negative regulation of hydrolase activity regulation of molecular function regulation of catalytic activity regulation of hydrolase activity negative regulation of cyclic-nucleotide phosphodiesterase activity negative regulation of molecular function negative regulation of catalytic activity regulation of cyclic-nucleotide phosphodiesterase activity	midbody cellular anatomical entity cell periphery cell cortex intracellular anatomical structure cytoplasm protein-containing complex extrinsic component of plasma membrane catalytic complex plasma membrane protein complex cytoplasmic side of membrane membrane plasma membrane membrane protein complex midbody cellular anatomical entity cell periphery cell cortex intracellular anatomical structure cytoplasm protein-containing complex extrinsic component of plasma membrane catalytic complex plasma membrane protein complex cytoplasmic side of membrane membrane plasma membrane membrane protein complex heterotrimeric G-protein complex side of membrane cytoplasmic side of plasma membrane GTPase complex extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane intracellular organelle centrosome microtubule organizing center cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle synapse cell junction glutamatergic synapse postsynapse membrane-bounded organelle nucleus intracellular membrane-bounded organelle non-motile cilium cilium 9+0 non-motile cilium neuron projection ciliary membrane photoreceptor outer segment membrane photoreceptor outer segment plasma membrane bounded cell projection cell projection bounding membrane of organelle photoreceptor cell cilium plasma membrane region organelle membrane cell projection membrane photoreceptor inner segment photoreceptor disc membrane plasma membrane signaling receptor complex G protein-coupled receptor complex receptor complex
B, D	Regulator of G-protein signaling 9	GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity	cellular response to stimulus regulation of signaling regulation of biological process regulation of cellular process response to stimulus negative regulation of signaling signaling negative regulation of response to stimulus biological regulation negative regulation of biological process regulation of signal transduction negative regulation of signal transduction negative regulation of cell communication cell communication regulation of response to stimulus cellular response to stimulus regulation of signaling regulation of biological process regulation of cellular process response to stimulus negative regulation of signaling signaling negative regulation of response to stimulus biological regulation negative regulation of biological process regulation of signal transduction negative regulation of signal transduction negative regulation of cell communication cell communication regulation of response to stimulus negative regulation of cellular process regulation of cell communication cellular process signal transduction G protein-coupled receptor signaling pathway regulation of G protein-coupled receptor signaling pathway multicellular organismal process sensory perception of light stimulus system process sensory perception nervous system process visual perception intracellular signal transduction	membrane-bounded organelle non-motile cilium membrane 9+0 non-motile cilium cilium neuron projection cellular anatomical entity photoreceptor disc membrane photoreceptor outer segment plasma membrane bounded cell projection cell projection photoreceptor cell cilium organelle organelle membrane membrane-bounded organelle non-motile cilium membrane 9+0 non-motile cilium cilium neuron projection cellular anatomical entity photoreceptor disc membrane photoreceptor outer segment plasma membrane bounded cell projection cell projection photoreceptor cell cilium organelle organelle membrane cell periphery plasma membrane intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR001019	Guanine nucleotide binding protein (G-protein), alpha subunit	Family
A, C	IPR011025	G protein alpha subunit, helical insertion	Homologous Superfamily
A, C	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, C	IPR001408	G-protein alpha subunit, group I	Family
A, C	IPR001408	G-protein alpha subunit, group I	Family
A, C	IPR001019	Guanine nucleotide binding protein (G-protein), alpha subunit	Family
A, C	IPR011025	G protein alpha subunit, helical insertion	Homologous Superfamily
A, C	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B, D	IPR016137	RGS domain	Domain
B, D	IPR000591	DEP domain	Domain
B, D	IPR036305	RGS domain superfamily	Homologous Superfamily
B, D	IPR047016	Regulator of G protein signaling 6/7/9/11	Family
B, D	IPR015898	G-protein gamma-like domain	Domain
B, D	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
B, D	IPR044926	RGS, subdomain 2	Homologous Superfamily
B, D	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
B, D	IPR036284	G-protein gamma-like domain superfamily	Homologous Superfamily
B, D	IPR040759	Regulator of G-protein signalling, DHEX domain	Domain
B, D	IPR047017	Regulator of G-protein signalling 6/7/9/11, DHEX domain superfamily	Homologous Superfamily
B, D	IPR047077	Regulator of G protein signaling 9, RGS domain	Domain