1FSU

Crystal Structure of 4-Sulfatase (human)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1fsua_	Alpha and beta proteins (a/b)	Alkaline phosphatase-like	Alkaline phosphatase-like	Arylsulfatase	Arylsulfatase B (4-sulfatase)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Sulfatases	8020384	4000785	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Alkaline phosphatase-like	8032764	3001353	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Arylsulfatase, C-terminal domain-like	8055770	3002305	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Sulfatase_1	e1fsuA1	A: a/b three-layered sandwiches	X: Alkaline phosphatase-like (From Topology)	H: Alkaline phosphatase-like (From Topology)	T: Alkaline phosphatase-like	F: Sulfatase_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.720.10	Alpha Beta	3-Layer(aba) Sandwich	Alkaline Phosphatase, subunit A	Alkaline Phosphatase, subunit A	CATH (4.3.0)
A	3.30.1120.10	Alpha Beta	2-Layer Sandwich	Arylsulfatase, C-terminal domain		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00884	Sulfatase (Sulfatase)	Sulfatase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	N-ACETYLGALACTOSAMINE-4-SULFATASE	N-acetylgalactosamine-4-sulfatase activity hydrolase activity, acting on ester bonds hydrolase activity catalytic activity sulfuric ester hydrolase activity arylsulfatase activity cation binding ion binding binding metal ion binding small molecule binding	response to stimulus response to hormone response to endogenous stimulus response to chemical response to estrogen response to methylmercury cellular catabolic process catabolic process cellular metabolic process autophagy cellular process metabolic process process utilizing autophagic mechanism intestinal epithelial cell migration response to stimulus response to hormone response to endogenous stimulus response to chemical response to estrogen response to methylmercury cellular catabolic process catabolic process cellular metabolic process autophagy cellular process metabolic process process utilizing autophagic mechanism intestinal epithelial cell migration epithelium migration multicellular organismal process colon epithelial cell migration tissue migration ameboidal-type cell migration epithelial cell migration cell migration cell motility cellular component organization lysosome organization organelle organization vacuole organization lytic vacuole organization cellular component organization or biogenesis regulation of neuron projection development regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization cellular developmental process cell projection organization positive regulation of biological process cell development neuron projection development neurogenesis multicellular organism development neuron differentiation positive regulation of neuron projection development cell differentiation anatomical structure development positive regulation of cell projection organization positive regulation of cellular process system development developmental process regulation of biological process plasma membrane bounded cell projection organization regulation of cell projection organization biological regulation nervous system development generation of neurons neuron development regulation of plasma membrane bounded cell projection organization response to pH response to abiotic stimulus localization cellular localization transport establishment of localization in cell vacuolar transport intracellular transport lysosomal transport establishment of localization regulation of cell motility regulation of locomotion regulation of cell migration regulation of multicellular organismal process regulation of epithelial cell migration locomotion response to nutrient levels response to nutrient	membrane-bounded organelle intracellular anatomical structure lytic vacuole membrane-enclosed lumen vacuolar lumen vacuole cellular anatomical entity intracellular membrane-bounded organelle lysosomal lumen intracellular organelle lumen intracellular organelle organelle lumen organelle cytoplasm membrane-bounded organelle intracellular anatomical structure lytic vacuole membrane-enclosed lumen vacuolar lumen vacuole cellular anatomical entity intracellular membrane-bounded organelle lysosomal lumen intracellular organelle lumen intracellular organelle organelle lumen organelle cytoplasm lysosome extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cell surface intracellular vesicle cytoplasmic vesicle lumen endomembrane system cytoplasmic vesicle vesicle lumen azurophil granule secretory granule lumen azurophil granule lumen secretory granule primary lysosome secretory vesicle ficolin-1-rich granule ficolin-1-rich granule lumen endoplasmic reticulum lumen endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR017850	Alkaline-phosphatase-like, core domain superfamily	Homologous Superfamily
A	IPR047115	Arylsulfatase B	Family
A	IPR024607	Sulfatase, conserved site	Conserved Site
A	IPR000917	Sulfatase, N-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P15848	mucopolysaccharidosis type 6 mucopolysaccharidosis leukodystrophy metachromatic leukodystrophy mucosulfatidosis Crohn disease inborn errors of metabolism lysosomal storage disease ovarian cancer tuberculosis hydrocephalus intellectual disability medulloblastoma Sjogren syndrome Hyperammonemia mucopolysaccharidosis type 6 mucopolysaccharidosis leukodystrophy metachromatic leukodystrophy mucosulfatidosis Crohn disease inborn errors of metabolism lysosomal storage disease ovarian cancer tuberculosis hydrocephalus intellectual disability medulloblastoma Sjogren syndrome Hyperammonemia sphingolipidosis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.