1FZ0

METHANE MONOOXYGENASE HYDROXYLASE, FORM II MIXED-VALENT GROWN ANAEROBICALLY

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1fz0a_	All alpha proteins	Ferritin-like	Ferritin-like	Ribonucleotide reductase-like	Methane monooxygenase hydrolase alpha subunit	(Methylococcus capsulatus ) [TaxId: 414 ],	SCOPe (2.08)
B	d1fz0b_	All alpha proteins	Ferritin-like	Ferritin-like	Ribonucleotide reductase-like	Methane monooxygenase hydrolase alpha subunit	(Methylococcus capsulatus ) [TaxId: 414 ],	SCOPe (2.08)
C	d1fz0c_	All alpha proteins	Ferritin-like	Ferritin-like	Ribonucleotide reductase-like	Methane monooxygenase hydrolase beta subunit	(Methylococcus capsulatus ) [TaxId: 414 ],	SCOPe (2.08)
D	d1fz0d_	All alpha proteins	Ferritin-like	Ferritin-like	Ribonucleotide reductase-like	Methane monooxygenase hydrolase beta subunit	(Methylococcus capsulatus ) [TaxId: 414 ],	SCOPe (2.08)
E	d1fz0e_	All alpha proteins	Open three-helical up-and-down bundle	Methane monooxygenase hydrolase, gamma subunit	Methane monooxygenase hydrolase, gamma subunit	Methane monooxygenase hydrolase, gamma subunit	(Methylococcus capsulatus ) [TaxId: 414 ],	SCOPe (2.08)
F	d1fz0f_	All alpha proteins	Open three-helical up-and-down bundle	Methane monooxygenase hydrolase, gamma subunit	Methane monooxygenase hydrolase, gamma subunit	Methane monooxygenase hydrolase, gamma subunit	(Methylococcus capsulatus ) [TaxId: 414 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Ferritin-like	8037016	3001658	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Ferritin-like	8037016	3001658	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Ferritin-like	8037015	3001658	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Ferritin-like	8037015	3001658	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Methane monooxygenase hydrolase, gamma subunit	8036843	3001468	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Methane monooxygenase hydrolase, gamma subunit	8036843	3001468	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Phenol_Hydrox	e1fz0A1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: Phenol_Hydrox	ECOD (1.6)
B	Phenol_Hydrox	e1fz0B1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: Phenol_Hydrox	ECOD (1.6)
C	Phenol_Hydrox	e1fz0C1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: Phenol_Hydrox	ECOD (1.6)
D	Phenol_Hydrox	e1fz0D1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: Phenol_Hydrox	ECOD (1.6)
E	MeMO_Hyd_G	e1fz0E1	A: alpha arrays	X: Methane monooxygenase hydrolase gamma subunit-like	H: Methane monooxygenase hydrolase gamma subunit (From Topology)	T: Methane monooxygenase hydrolase gamma subunit	F: MeMO_Hyd_G	ECOD (1.6)
F	MeMO_Hyd_G	e1fz0F1	A: alpha arrays	X: Methane monooxygenase hydrolase gamma subunit-like	H: Methane monooxygenase hydrolase gamma subunit (From Topology)	T: Methane monooxygenase hydrolase gamma subunit	F: MeMO_Hyd_G	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.620.20	Mainly Alpha	Orthogonal Bundle	Ribonucleotide Reductase, subunit A	Ribonucleotide Reductase, subunit A	CATH (4.3.0)
B	1.10.620.20	Mainly Alpha	Orthogonal Bundle	Ribonucleotide Reductase, subunit A	Ribonucleotide Reductase, subunit A	CATH (4.3.0)
C	1.10.620.20	Mainly Alpha	Orthogonal Bundle	Ribonucleotide Reductase, subunit A	Ribonucleotide Reductase, subunit A	CATH (4.3.0)
D	1.10.620.20	Mainly Alpha	Orthogonal Bundle	Ribonucleotide Reductase, subunit A	Ribonucleotide Reductase, subunit A	CATH (4.3.0)
E	1.20.1280.10	Mainly Alpha	Up-down Bundle	Monooxygenase	Methane monooxygenase, gamma chain, domain 1	CATH (4.3.0)
E	1.20.1280.30	Mainly Alpha	Up-down Bundle	Monooxygenase	Methane monooxygenase, gamma chain, domain 2	CATH (4.3.0)
F	1.20.1280.10	Mainly Alpha	Up-down Bundle	Monooxygenase	Methane monooxygenase, gamma chain, domain 1	CATH (4.3.0)
F	1.20.1280.30	Mainly Alpha	Up-down Bundle	Monooxygenase	Methane monooxygenase, gamma chain, domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02332	Methane/Phenol/Alkene Hydroxylase (Phenol_Hydrox)	Methane/Phenol/Alkene Hydroxylase	This protein family includes several components of multicomponent enzyme systems predominantly found in Proteobacteria and Actinobacteria, including subunits alpha and beta of a methane monooxygenase and an alkene monooxygenase system, small and larg ...	This protein family includes several components of multicomponent enzyme systems predominantly found in Proteobacteria and Actinobacteria, including subunits alpha and beta of a methane monooxygenase and an alkene monooxygenase system, small and large subunits of propane 2-monooxygenase system and P1 protein of phenol hydroxylase [1-4].	Domain
C, D	PF02332	Methane/Phenol/Alkene Hydroxylase (Phenol_Hydrox)	Methane/Phenol/Alkene Hydroxylase	This protein family includes several components of multicomponent enzyme systems predominantly found in Proteobacteria and Actinobacteria, including subunits alpha and beta of a methane monooxygenase and an alkene monooxygenase system, small and larg ...	This protein family includes several components of multicomponent enzyme systems predominantly found in Proteobacteria and Actinobacteria, including subunits alpha and beta of a methane monooxygenase and an alkene monooxygenase system, small and large subunits of propane 2-monooxygenase system and P1 protein of phenol hydroxylase [1-4].	Domain
E, F	PF02964	Methane monooxygenase, hydrolase gamma chain (MeMO_Hyd_G)	Methane monooxygenase, hydrolase gamma chain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	METHANE MONOOXYGENASE COMPONENT A, ALPHA CHAIN	cation binding ion binding binding metal ion binding small molecule binding	cellular metabolic process small molecule metabolic process metabolic process cellular process one-carbon metabolic process	-
C, D	METHANE MONOOXYGENASE COMPONENT A, BETA CHAIN	-	cellular metabolic process small molecule metabolic process metabolic process cellular process one-carbon metabolic process	-
E, F	METHANE MONOOXYGENASE COMPONENT A, GAMMA CHAIN	-	cellular metabolic process cellular alkane metabolic process methane metabolic process metabolic process cellular process hydrocarbon metabolic process small molecule metabolic process one-carbon metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR009078	Ferritin-like superfamily	Homologous Superfamily
A, B	IPR003430	Propane/methane/phenol/toluene hydroxylase	Family
A, B	IPR012348	Ribonucleotide reductase-like	Homologous Superfamily
C, D	IPR009078	Ferritin-like superfamily	Homologous Superfamily
C, D	IPR003430	Propane/methane/phenol/toluene hydroxylase	Family
C, D	IPR012078	Methane/phenol monooxygenase, hydroxylase component	Family
C, D	IPR012348	Ribonucleotide reductase-like	Homologous Superfamily
E, F	IPR015952	Methane monooxygenase, gamma chain, domain 1	Homologous Superfamily
E, F	IPR015953	Methane monooxygenase, gamma chain, domain 2	Homologous Superfamily
E, F	IPR036123	Methane monooxygenase, gamma chain superfamily	Homologous Superfamily
E, F	IPR004222	Methane monooxygenase, gamma chain	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.