Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyConcanavalin A-like lectins/glucanases 8041452 3000120 SCOP2B (2022-06-29)
ASCOP2B SuperfamilySTI-like 8042038 3000715 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyMetalloproteases (zincins), catalytic domain 8035461 3001975 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyClostridium neurotoxins, coiled-coil domain 8039657 3001677 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AToxin_R_bind_Ne1g9bA1 A: beta sandwichesX: jelly-rollH: Concanavalin A-likeT: Concanavalin A-like lectins/glucanasesF: Toxin_R_bind_NECOD (1.6)
AToxin_R_bind_Ce1g9bA2 A: beta duplicates or obligate multimersX: beta-Trefoil (From Topology)H: beta-Trefoil (From Topology)T: beta-TrefoilF: Toxin_R_bind_CECOD (1.6)
APeptidase_M27e1g9bA3 A: mixed a+b and a/bX: Zincin-likeH: Metalloproteases (zincins) catalytic domain (From Topology)T: Metalloproteases (zincins) catalytic domainF: Peptidase_M27ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF07951Clostridium neurotoxin, C-terminal receptor binding (Toxin_R_bind_C)Clostridium neurotoxin, C-terminal receptor bindingThe Clostridium neurotoxin family is composed of tetanus neurotoxins and seven serotypes of botulinum neurotoxin. The structure of the botulinum neurotoxin reveals a four domain protein. The N-terminal catalytic domain (Pfam:PF01742), the central tr ...The Clostridium neurotoxin family is composed of tetanus neurotoxins and seven serotypes of botulinum neurotoxin. The structure of the botulinum neurotoxin reveals a four domain protein. The N-terminal catalytic domain (Pfam:PF01742), the central translocation domains and two receptor binding domains [1]. This domains is the C-terminal receptor binding domain, which adopts a modified beta-trefoil fold with a six stranded beta-barrel and a beta-hairpin triplet capping the domain [1]. The first step in the intoxication process is a binding event between this domains and the pre-synaptic nerve ending [1].
Domain
PF07952Clostridium neurotoxin, Translocation domain (Toxin_trans)Clostridium neurotoxin, Translocation domainThe Clostridium neurotoxin family is composed of tetanus neurotoxin and seven serotypes of botulinum neurotoxin. The structure of the botulinum neurotoxin reveals a four domain protein. The N-terminal catalytic domain (Pfam:PF01742), the central tra ...The Clostridium neurotoxin family is composed of tetanus neurotoxin and seven serotypes of botulinum neurotoxin. The structure of the botulinum neurotoxin reveals a four domain protein. The N-terminal catalytic domain (Pfam:PF01742), the central translocation domains and two receptor binding domains [1]. Subsequent to cell surface binding and receptor mediated endocytosis of the neurotoxin, an acid induced conformational change in the neurotoxin translocation domain is believed to allow the domain to penetrate the endosome and from a pore, thereby facilitating the passage of the catalytic domain across the membrane into the cytosol [1]. The structure of the translocation reveals a pair of helices that are 105 Angstroms long and is structurally distinct from other pore forming toxins [1].
Domain
PF07953Clostridium neurotoxin, N-terminal receptor binding (Toxin_R_bind_N)Clostridium neurotoxin, N-terminal receptor bindingThe Clostridium neurotoxin family is composed of tetanus neurotoxin and seven serotypes of botulinum neurotoxin. The structure of the botulinum neurotoxin reveals a four domain protein. The N-terminal catalytic domain (Pfam:PF01742), the central tra ...The Clostridium neurotoxin family is composed of tetanus neurotoxin and seven serotypes of botulinum neurotoxin. The structure of the botulinum neurotoxin reveals a four domain protein. The N-terminal catalytic domain (Pfam:PF01742), the central translocation domains and two receptor binding domains [1]. This domains is the N-terminal receptor binding domain,which is comprised of two seven-stranded beta-sheets sandwiched together to form a jelly role motif [1]. The role of this domain in receptor binding appears to be indirect.
Domain
PF01742Clostridial neurotoxin zinc protease (Peptidase_M27)Clostridial neurotoxin zinc protease- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
BOTULINUM NEUROTOXIN TYPE B