1GXS
Crystal Structure of Hydroxynitrile Lyase from Sorghum bicolor in Complex with Inhibitor Benzoic Acid: a novel cyanogenic enzyme
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d1gxs.1 | Alpha and beta proteins (a/b) | alpha/beta-Hydrolases | alpha/beta-Hydrolases | Serine carboxypeptidase-like | Hydroxynitrile lyase | (Sorghum bicolor ) [TaxId: 4558 ], | SCOPe (2.08) |
C | d1gxs.2 | Alpha and beta proteins (a/b) | alpha/beta-Hydrolases | alpha/beta-Hydrolases | Serine carboxypeptidase-like | Hydroxynitrile lyase | (Sorghum bicolor ) [TaxId: 4558 ], | SCOPe (2.08) |
B | d1gxs.1 | Alpha and beta proteins (a/b) | alpha/beta-Hydrolases | alpha/beta-Hydrolases | Serine carboxypeptidase-like | Hydroxynitrile lyase | (Sorghum bicolor ) [TaxId: 4558 ], | SCOPe (2.08) |
D | d1gxs.2 | Alpha and beta proteins (a/b) | alpha/beta-Hydrolases | alpha/beta-Hydrolases | Serine carboxypeptidase-like | Hydroxynitrile lyase | (Sorghum bicolor ) [TaxId: 4558 ], | SCOPe (2.08) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.40.50.1820 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | Alpha/Beta hydrolase fold, catalytic domain | CATH (4.3.0) |
C | 3.40.50.1820 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | Alpha/Beta hydrolase fold, catalytic domain | CATH (4.3.0) |
B | 6.10.250.940 | Special | Helix non-globular | Single alpha-helices involved in coiled-coils or other helix-helix interfaces | CATH (4.3.0) | |
B | 3.40.50.11320 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | CATH (4.3.0) | |
D | 6.10.250.940 | Special | Helix non-globular | Single alpha-helices involved in coiled-coils or other helix-helix interfaces | CATH (4.3.0) | |
D | 3.40.50.11320 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00450 | Serine carboxypeptidase (Peptidase_S10) | Serine carboxypeptidase | - | Domain | |
PF00450 | Serine carboxypeptidase (Peptidase_S10) | Serine carboxypeptidase | - | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
Chains | Polymer | Molecular Function | Biological Process | Cellular Component |
---|---|---|---|---|
P-(S)-HYDROXYMANDELONITRILE LYASE CHAIN A | - | - | ||
P-(S)-HYDROXYMANDELONITRILE LYASE CHAIN B | - | - |
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR001563 | Peptidase S10, serine carboxypeptidase | Family | |
IPR033124 | Serine carboxypeptidases, histidine active site | Active Site | |
IPR029058 | Alpha/Beta hydrolase fold | Homologous Superfamily | |
IPR001563 | Peptidase S10, serine carboxypeptidase | Family | |
IPR033124 | Serine carboxypeptidases, histidine active site | Active Site | |
IPR029058 | Alpha/Beta hydrolase fold | Homologous Superfamily |
Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage
Chains | Enzyme Name | Description | Catalytic Residues |
---|---|---|---|
P-(S)-hydroxymandelonitrile lyase M-CSA #382 | Hydroxynitrile lyases (HNLs) constitute a diverse family of enzymes that catalyse the stereospecific cleavage of a wide range of cyanohydrins into aldehydes or ketones and hydrogen cyanide from injured tissues. It is also involved in the catabolism of the cyanogenic glycoside dhurrin. | EC: 4.1.2.11 (PDB Primary Data) |