1H10

HIGH RESOLUTION STRUCTURE OF THE PLECKSTRIN HOMOLOGY DOMAIN OF PROTEIN KINASE B/AKT BOUND TO INS(1,3,4,5)-TETRAKISPHOPHATE

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1h10a_	All beta proteins	PH domain-like barrel	PH domain-like	Pleckstrin-homology domain (PH domain)	Rac-alpha serine/threonine kinase	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	PH domain-like	8040941	3000134	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PH	e1h10A1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PH	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00169	PH domain (PH)	PH domain	PH stands for pleckstrin homology.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	RAC-ALPHA SERINE/THREONINE KINASE	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding phosphatidylinositol-3,4-bisphosphate binding potassium channel regulator activity transporter activator activity channel regulator activity potassium channel activator activity molecular function activator activity ion channel regulator activity molecular function regulator activity channel activator activity transporter regulator activity protein binding calmodulin binding protein serine/threonine/tyrosine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups identical protein binding protein homodimerization activity protein dimerization activity kinase binding enzyme binding protein kinase binding protein serine/threonine kinase activity phosphatidylinositol-3,4,5-trisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding 14-3-3 protein binding enzyme regulator activity nitric-oxide synthase regulator activity protein serine kinase activity protein kinase inhibitor activity molecular function inhibitor activity enzyme inhibitor activity protein kinase regulator activity protein serine/threonine kinase inhibitor activity kinase inhibitor activity kinase regulator activity	regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process positive regulation of nitric oxide biosynthetic process regulation of metabolic process cellular response to stimulus cellular response to nitrogen compound response to ketone response to stimulus response to alcohol cellular response to organic cyclic compound response to oxygen-containing compound response to nitrogen compound cellular response to ether cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to alcohol response to ether response to chemical response to rapamycin cellular process cellular response to rapamycin cellular response to ketone response to organic cyclic compound regulation of protein binding regulation of molecular function negative regulation of protein binding negative regulation of binding regulation of binding negative regulation of molecular function regulation of cellular process regulation of cell adhesion negative regulation of biological process leukocyte cell-cell adhesion negative regulation of cell adhesion cell adhesion cell-cell adhesion negative regulation of leukocyte cell-cell adhesion negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of cellular process regulation of cell-cell adhesion cellular response to low-density lipoprotein particle stimulus cellular response to oxidised low-density lipoprotein particle stimulus response to endogenous stimulus response to lipoprotein particle cellular response to lipoprotein particle stimulus positive regulation of protein localization to plasma membrane protein localization regulation of localization cellular localization regulation of protein localization localization cellular macromolecule localization regulation of protein localization to membrane positive regulation of cellular process positive regulation of protein localization to cell periphery protein localization to cell periphery protein localization to plasma membrane positive regulation of protein localization to membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane regulation of cellular localization macromolecule localization positive regulation of protein localization regulation of protein localization to plasma membrane positive regulation of DNA-binding transcription factor activity cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of gene expression regulation of DNA-binding transcription factor activity regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process regulation of peptidyl-serine phosphorylation positive regulation of cellular metabolic process positive regulation of phosphate metabolic process peptidyl-serine modification positive regulation of protein modification process peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process positive regulation of peptidyl-serine phosphorylation macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation positive regulation of proteasomal protein catabolic process catabolic process proteolysis involved in protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process proteolysis proteasomal protein catabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process regulation of protein catabolic process ameboidal-type cell migration cell migration fibroblast migration cell motility cell surface receptor signaling pathway signaling insulin-like growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cell communication signal transduction enzyme-linked receptor protein signaling pathway non-canonical NF-kappaB signal transduction intracellular signal transduction intracellular signaling cassette behavior multicellular organismal process response to stress multicellular organismal response to stress response to pain behavioral response to pain response to prostaglandin response to lipid cellular response to prostaglandin stimulus cellular response to endogenous stimulus cellular response to prostaglandin E stimulus response to hormone cellular response to lipid response to prostaglandin E cellular response to hormone stimulus establishment of protein localization establishment of localization establishment of protein localization to organelle protein localization to organelle protein localization to mitochondrion establishment of protein localization to mitochondrion symbiont-mediated perturbation of host defense response response to host defenses biological process involved in interspecies interaction between organisms response to other organism response to defenses of other organism modulation by virus of host process response to external stimulus virus-mediated perturbation of host defense response biological process involved in interaction with host response to biotic stimulus biological process involved in symbiotic interaction symbiont-mediated perturbation of host process viral process response to host response to external biotic stimulus modulation of process of another organism modulation by virus of host cellular process cell population proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation response to growth hormone response to peptide hormone negative regulation of cellular catabolic process negative regulation of catabolic process negative regulation of metabolic process autophagy regulation of autophagy negative regulation of cellular metabolic process cellular catabolic process negative regulation of autophagy regulation of cellular catabolic process process utilizing autophagic mechanism developmental process muscle structure development cellular developmental process cell differentiation anatomical structure development striated muscle cell differentiation muscle cell differentiation sphingolipid mediated signaling pathway sphingosine-1-phosphate receptor signaling pathway G protein-coupled receptor signaling pathway anoikis apoptotic process cell death programmed cell death positive regulation of response to biotic stimulus pattern recognition receptor signaling pathway regulation of signal transduction cGAS/STING signaling pathway immune response-activating signaling pathway positive regulation of immune response regulation of immune system process positive regulation of immune system process innate immune response-activating signaling pathway immune response regulation of innate immune response negative regulation of cGAS/STING signaling pathway regulation of response to stimulus defense response to other organism regulation of pattern recognition receptor signaling pathway positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of defense response regulation of response to biotic stimulus regulation of response to external stimulus intracellular receptor signaling pathway negative regulation of signaling negative regulation of cytoplasmic pattern recognition receptor signaling pathway negative regulation of intracellular signal transduction regulation of cytoplasmic pattern recognition receptor signaling pathway negative regulation of cell communication positive regulation of response to stimulus positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of intracellular signal transduction regulation of response to stress innate immune response regulation of signaling positive regulation of innate immune response defense response negative regulation of response to stimulus defense response to symbiont negative regulation of signal transduction negative regulation of immune system process immune system process regulation of cell communication response to heat response to abiotic stimulus response to temperature stimulus regulation of cellular component organization postsynapse organization regulation of postsynapse organization cellular component organization regulation of synapse organization cell junction organization regulation of synapse structure or activity synapse organization cellular component organization or biogenesis regulation of biological quality regulation of growth growth positive regulation of cell growth regulation of cell growth cell growth positive regulation of growth response to insulin-like growth factor stimulus organelle organization apoptotic mitochondrial changes mitochondrion organization negative regulation of extrinsic apoptotic signaling pathway in absence of ligand signal transduction in absence of ligand regulation of programmed cell death extrinsic apoptotic signaling pathway negative regulation of signal transduction in absence of ligand negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand negative regulation of programmed cell death regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of apoptotic signaling pathway regulation of generation of precursor metabolites and energy positive regulation of macromolecule biosynthetic process positive regulation of glycogen metabolic process regulation of small molecule metabolic process small molecule metabolic process carbohydrate biosynthetic process hexose metabolic process positive regulation of glucose metabolic process positive regulation of glycogen biosynthetic process energy reserve metabolic process positive regulation of carbohydrate metabolic process regulation of glycogen metabolic process monosaccharide metabolic process regulation of glycogen biosynthetic process glucan biosynthetic process energy derivation by oxidation of organic compounds regulation of glucan biosynthetic process regulation of polysaccharide metabolic process polysaccharide metabolic process glucan metabolic process regulation of carbohydrate metabolic process regulation of glucose metabolic process carbohydrate metabolic process polysaccharide biosynthetic process glycogen metabolic process generation of precursor metabolites and energy glycogen biosynthetic process regulation of polysaccharide biosynthetic process regulation of carbohydrate biosynthetic process positive regulation of small molecule metabolic process positive regulation of cellular biosynthetic process glucose metabolic process regulation of protein maturation negative regulation of protein maturation protein maturation negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process execution phase of apoptosis negative regulation of proteolysis regulation of catalytic activity regulation of cyclin-dependent protein kinase activity regulation of transferase activity positive regulation of protein serine/threonine kinase activity positive regulation of cyclin-dependent protein serine/threonine kinase activity regulation of cyclin-dependent protein serine/threonine kinase activity cell cycle positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity positive regulation of cyclin-dependent protein kinase activity positive regulation of protein kinase activity regulation of cell cycle positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity positive regulation of cell cycle regulation of tRNA processing tRNA processing RNA processing tRNA modification macromolecule methylation tRNA metabolic process RNA modification methylation regulation of tRNA metabolic process RNA methylation tRNA methylation regulation of tRNA methylation Notch signaling pathway negative regulation of Notch signaling pathway regulation of Notch signaling pathway regulation of endodeoxyribonuclease activity regulation of deoxyribonuclease activity regulation of nuclease activity positive regulation of endodeoxyribonuclease activity positive regulation of deoxyribonuclease activity positive regulation of nucleobase-containing compound metabolic process positive regulation of nuclease activity DNA metabolic process positive regulation of hydrolase activity positive regulation of DNA metabolic process regulation of hydrolase activity regulation of DNA metabolic process response to peptide response to granulocyte macrophage colony-stimulating factor response to cytokine cellular response to cytokine stimulus cellular response to granulocyte macrophage colony-stimulating factor stimulus cellular response to tumor necrosis factor response to tumor necrosis factor regulation of postsynaptic membrane potential system process chemical synaptic transmission, postsynaptic synaptic signaling trans-synaptic signaling nervous system process cell-cell signaling chemical synaptic transmission anterograde trans-synaptic signaling excitatory postsynaptic potential regulation of membrane potential negative regulation of hydrolase activity negative regulation of catalytic activity negative regulation of endopeptidase activity negative regulation of peptidase activity regulation of endopeptidase activity regulation of peptidase activity positive regulation of locomotion regulation of cell motility regulation of blood vessel endothelial cell migration endothelial cell migration positive regulation of cell migration positive regulation of blood vessel endothelial cell migration regulation of locomotion positive regulation of endothelial cell migration positive regulation of cell motility regulation of cell migration blood vessel endothelial cell migration regulation of endothelial cell migration locomotion negative regulation of protein localization to lysosome protein localization to vacuole regulation of protein localization to lysosome protein localization to lysosome negative regulation of protein localization insulin receptor signaling pathway cellular response to peptide hormone stimulus response to insulin cellular response to insulin stimulus regulation of developmental growth regulation of developmental process developmental growth positive regulation of organ growth organ growth positive regulation of developmental process regulation of organ growth positive regulation of multicellular organismal process regulation of multicellular organismal process positive regulation of developmental growth response to growth factor import into cell carboxylic acid transmembrane transport transport fatty acid transmembrane transport regulation of lipid transport negative regulation of transport negative regulation of lipid localization negative regulation of transmembrane transport long-chain fatty acid import across plasma membrane regulation of long-chain fatty acid import across plasma membrane monocarboxylic acid transport fatty acid transport lipid import into cell long-chain fatty acid import into cell long-chain fatty acid transport organic acid transmembrane transport organic anion transport negative regulation of lipid transport carboxylic acid transport regulation of transport negative regulation of fatty acid transport import across plasma membrane negative regulation of long-chain fatty acid import across plasma membrane regulation of long-chain fatty acid import into cell lipid localization lipid transport regulation of fatty acid transport organic acid transport transmembrane transport regulation of transmembrane transport negative regulation of long-chain fatty acid import into cell regulation of lipid localization negative regulation of organic acid transport regulation of organic acid transport inflammatory response signal transduction by p53 class mediator regulation of signal transduction by p53 class mediator cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus response to epidermal growth factor response to oxidative stress endothelial cell proliferation positive regulation of epithelial cell proliferation regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation regulation of neuron projection development cell projection organization cell development neuron projection development neurogenesis multicellular organism development neuron differentiation system development plasma membrane bounded cell projection organization regulation of cell projection organization nervous system development generation of neurons neuron development regulation of plasma membrane bounded cell projection organization regulation of protein localization to endoplasmic reticulum protein localization to endoplasmic reticulum positive regulation of protein localization to endoplasmic reticulum cellular response to interleukin-18 response to interleukin-18 cytokine-mediated signaling pathway interleukin-18-mediated signaling pathway maintenance of protein location maintenance of protein location in mitochondrion maintenance of location maintenance of location in cell maintenance of protein location in cell maintenance of protein localization in organelle hexose transmembrane transport D-glucose import carbohydrate transport positive regulation of D-glucose transmembrane transport positive regulation of transmembrane transport regulation of D-glucose import positive regulation of D-glucose import positive regulation of transport D-glucose transmembrane transport regulation of D-glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity negative regulation of cysteine-type endopeptidase activity regulation of oxidoreductase activity positive regulation of oxidoreductase activity positive regulation of nitric-oxide synthase activity regulation of monooxygenase activity positive regulation of monooxygenase activity regulation of nitric-oxide synthase activity mammary gland epithelial cell differentiation epithelium development mammary gland development gland development animal organ development tissue development epithelial cell differentiation mammary gland epithelium development negative regulation of post-translational protein modification regulation of protein ubiquitination protein ubiquitination negative regulation of protein modification process negative regulation of protein ubiquitination regulation of protein modification by small protein conjugation or removal negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal positive regulation of gene expression post-transcriptional regulation of gene expression translation regulation of translation cell migration involved in sprouting angiogenesis blood vessel morphogenesis tube development angiogenesis sprouting angiogenesis vasculature development circulatory system development anatomical structure morphogenesis tube morphogenesis anatomical structure formation involved in morphogenesis blood vessel development peptidyl-threonine modification peptidyl-threonine phosphorylation nitrogen compound transport nucleocytoplasmic transport nuclear transport intracellular transport protein localization to nucleus import into nucleus protein transport establishment of localization in cell protein import into nucleus intracellular protein transport cellular response to nerve growth factor stimulus response to nerve growth factor regulation of cell cycle phase transition cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle phase transition positive regulation of cell cycle process positive regulation of mitotic cell cycle cell cycle process positive regulation of G1/S transition of mitotic cell cycle regulation of cell cycle process regulation of mitotic cell cycle phase transition positive regulation of cell cycle G1/S phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle positive regulation of cell cycle phase transition G1/S transition of mitotic cell cycle mitotic cell cycle phase transition protein autophosphorylation multi-multicellular organism process placenta development reproductive process maternal process involved in female pregnancy multicellular organismal reproductive process developmental process involved in reproduction maternal placenta development female pregnancy multi-organism reproductive process negative regulation of mononuclear cell migration negative regulation of locomotion regulation of lymphocyte migration negative regulation of lymphocyte migration regulation of mononuclear cell migration negative regulation of cell migration regulation of leukocyte migration lymphocyte migration leukocyte migration negative regulation of leukocyte migration mononuclear cell migration negative regulation of cell motility negative regulation of phosphate metabolic process negative regulation of kinase activity negative regulation of transferase activity negative regulation of protein kinase activity negative regulation of protein phosphorylation negative regulation of phosphorus metabolic process negative regulation of phosphorylation cellular response to peptide response to light stimulus response to radiation response to UV response to UV-A ERBB signaling pathway epidermal growth factor receptor signaling pathway regulation of release of cytochrome c from mitochondria negative regulation of release of cytochrome c from mitochondria negative regulation of cellular component organization regulation of organelle organization release of cytochrome c from mitochondria negative regulation of organelle organization regulation of mitochondrion organization positive regulation of protein localization to cell surface protein localization to cell surface regulation of protein localization to cell surface TOR signaling I-kappaB phosphorylation positive regulation of I-kappaB phosphorylation canonical NF-kappaB signal transduction regulation of I-kappaB phosphorylation regulation of leukocyte activation regulation of cell activation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte activation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell activation T cell activation positive regulation of leukocyte activation positive regulation of T cell activation positive regulation of cell adhesion cell activation regulation of T cell activation lymphocyte costimulation T cell costimulation regulation of lymphocyte activation fat cell differentiation positive regulation of fat cell differentiation regulation of cell differentiation positive regulation of cell differentiation regulation of fat cell differentiation cellular response to metal ion response to metal ion cellular response to cadmium ion response to cadmium ion peripheral nervous system axon ensheathment glial cell development gliogenesis axon ensheathment ensheathment of neurons plasma membrane organization myelination in peripheral nervous system peripheral nervous system myelin maintenance Schwann cell differentiation endomembrane system organization membrane organization peripheral nervous system development myelination Schwann cell development glial cell differentiation myelin maintenance positive regulation of DNA-templated transcription transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process cellular response to vascular endothelial growth factor stimulus chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis response to fluid shear stress regulation of type B pancreatic cell development regulation of cell development pancreas development columnar/cuboidal epithelial cell development endocrine pancreas development type B pancreatic cell differentiation glandular epithelial cell development endocrine system development type B pancreatic cell development glandular epithelial cell differentiation epithelial cell development enteroendocrine cell differentiation columnar/cuboidal epithelial cell differentiation ossification osteoblast differentiation positive regulation of protein localization to nucleus regulation of protein localization to nucleus RNA catabolic process mRNA catabolic process nucleobase-containing compound catabolic process nucleic acid catabolic process regulation of mRNA catabolic process mRNA metabolic process regulation of mRNA stability regulation of RNA stability regulation of mRNA metabolic process regulation of multicellular organismal development regulation of myelination regulation of nervous system development labyrinthine layer blood vessel development placenta blood vessel development chordate embryonic development labyrinthine layer development embryo development in utero embryonic development embryonic placenta development embryo development ending in birth or egg hatching embryonic organ development phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of fibroblast migration positive regulation of fibroblast migration cellular response to lipopolysaccharide lipopolysaccharide-mediated signaling pathway cellular response to biotic stimulus response to bacterium cellular response to molecule of bacterial origin response to lipopolysaccharide response to molecule of bacterial origin sexual reproduction oogenesis cellular process involved in reproduction in multicellular organism female gamete generation gamete generation germ cell development mammalian oogenesis stage macroautophagy negative regulation of macroautophagy regulation of macroautophagy negative regulation of organelle assembly plasma membrane bounded cell projection assembly cellular component biogenesis negative regulation of plasma membrane bounded cell projection assembly cellular component assembly cilium assembly negative regulation of cell projection organization cilium organization organelle assembly regulation of cell projection assembly regulation of cellular component biogenesis regulation of plasma membrane bounded cell projection assembly regulation of cilium assembly regulation of organelle assembly negative regulation of cilium assembly cell projection assembly regulation of lipid metabolic process lipid biosynthetic process positive regulation of lipid biosynthetic process positive regulation of lipid metabolic process regulation of lipid biosynthetic process lipid metabolic process leukocyte apoptotic process lymphocyte apoptotic process multicellular organismal-level homeostasis leukocyte homeostasis T cell homeostasis activation-induced cell death of T cells homeostasis of number of cells T cell apoptotic process lymphocyte homeostasis positive regulation of cell communication positive regulation of signal transduction positive regulation of TORC1 signaling positive regulation of TOR signaling regulation of TORC1 signaling regulation of TOR signaling positive regulation of intracellular signal transduction TORC1 signaling positive regulation of signaling response to decreased oxygen levels cellular response to oxygen levels response to oxygen levels cellular response to decreased oxygen levels intrinsic apoptotic signaling pathway in response to oxidative stress regulation of oxidative stress-induced intrinsic apoptotic signaling pathway regulation of intrinsic apoptotic signaling pathway intrinsic apoptotic signaling pathway negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway cellular response to oxidative stress cellular response to chemical stress response to reactive oxygen species cellular response to reactive oxygen species cellular response to stress negative regulation of protein serine/threonine kinase activity regulation of monoatomic ion transport regulation of sodium ion transport metal ion transport positive regulation of sodium ion transport positive regulation of monoatomic ion transport monoatomic ion transport monoatomic cation transport regulation of metal ion transport sodium ion transport response to nutrient levels response to food cell differentiation involved in embryonic placenta development spongiotrophoblast layer development glycogen cell differentiation involved in embryonic placenta development negative regulation of small molecule metabolic process negative regulation of fatty acid beta-oxidation oxoacid metabolic process organic acid catabolic process organic acid metabolic process cellular lipid catabolic process regulation of fatty acid oxidation monocarboxylic acid catabolic process cellular ketone metabolic process carboxylic acid catabolic process negative regulation of lipid catabolic process regulation of cellular ketone metabolic process regulation of fatty acid beta-oxidation regulation of lipid catabolic process cellular lipid metabolic process regulation of fatty acid metabolic process monocarboxylic acid metabolic process small molecule catabolic process negative regulation of lipid metabolic process negative regulation of fatty acid oxidation fatty acid oxidation fatty acid beta-oxidation lipid oxidation fatty acid metabolic process lipid catabolic process negative regulation of fatty acid metabolic process carboxylic acid metabolic process lipid modification fatty acid catabolic process	cell-cell junction anchoring junction cell junction cellular anatomical entity intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle cilium plasma membrane bounded cell projection intracellular organelle ciliary basal body cell projection microtubule organizing center cell-cell junction anchoring junction cell junction cellular anatomical entity intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle cilium plasma membrane bounded cell projection intracellular organelle ciliary basal body cell projection microtubule organizing center cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle mitochondrial intermembrane space mitochondrion membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen organelle envelope lumen organelle envelope organelle lumen mitochondrial envelope cell periphery plasma membrane membrane protein-containing complex cell leading edge lamellipodium synapse glutamatergic synapse spindle postsynapse cell cortex vesicle nucleus nucleoplasm nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000719	Protein kinase domain	Domain
A	IPR017892	Protein kinase, C-terminal	Domain
A	IPR017441	Protein kinase, ATP binding site	Binding Site
A	IPR034676	Protein kinase B alpha, catalytic domain	Domain
A	IPR008271	Serine/threonine-protein kinase, active site	Active Site
A	IPR001849	Pleckstrin homology domain	Domain
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR000961	AGC-kinase, C-terminal	Domain
A	IPR039026	Protein Kinase B, pleckstrin homology domain	Domain
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P31749	Proteus syndrome schizophrenia classic familial adenomatous polyposis Cowden disease ovarian cancer colorectal cancer Cowden syndrome 6 cardiomyopathy muscular atrophy acute promyelocytic leukemia secretory meningioma obesity disorder cancer meningioma squamous cell carcinoma Proteus syndrome schizophrenia classic familial adenomatous polyposis Cowden disease ovarian cancer colorectal cancer Cowden syndrome 6 cardiomyopathy muscular atrophy acute promyelocytic leukemia secretory meningioma obesity disorder cancer meningioma squamous cell carcinoma breast carcinoma Pain transitional meningioma fibrous meningioma parasagittal meningioma prostate cancer microcystic meningioma angiomatous meningioma intraorbital meningioma breast cancer T-cell non-Hodgkin lymphoma epilepsy cannabis dependence cerebral convexity meningioma meningothelial meningioma skin neoplasm intraventricular meningioma spinal meningioma amphetamine abuse clear cell meningioma hyperplasia psammomatous meningioma skin cancer benign meningioma olfactory groove meningioma breast adenocarcinoma lymphatic system disease endometrium adenocarcinoma uterine disease head and neck squamous cell carcinoma precancerous condition hyperglycemia colonic disease hypertensive disorder colorectal carcinoma inflammatory bowel disease atherosclerosis coronary artery disease skin disease non-small cell lung carcinoma liver disease bipolar disorder osteosarcoma lung disease ovarian disease endometrial carcinoma lymphoplasmacyte-rich meningioma breast disease type 2 diabetes mellitus eye disease genetic intestinal polyposis heart disease melanoma hematologic disease prostate disease hyperinsulinism colorectal adenocarcinoma inborn carbohydrate metabolic disorder aortic valve calcification intellectual disability neurodegenerative disease benign fibrous histiocytoma cutaneous melanoma lung adenocarcinoma bone disease stomach disease ovarian neoplasm endometriosis toxic encephalopathy urinary bladder disease papillary meningioma cerebrovascular disorder prostate adenocarcinoma hereditary breast carcinoma mouth disease autoimmune disease kidney disease depressive disorder lung benign neoplasm ovarian carcinoma drug psychosis

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	ACE	RESID: AA0041 , AA0042 , AA0043 , AA0044 , AA0045 , AA0046 , AA0049 , AA0050 , AA0051 , AA0052 , AA0053 , AA0054 , AA0354 PSI-MOD : N-acetyl-L-alanine MOD:00050 , N-acetyl-L-aspartic acid MOD:00051 , N-acetyl-L-cysteine MOD:00052 , N-acetyl-S-archeol-cysteine MOD:00897 , N-acetyl-L-glutamic acid MOD:00053 , N-acetyl-L-glutamine MOD:00054 , N-acetylglycine MOD:00055 , N-acetyl-L-methionine MOD:00058 , N-acetyl-L-proline MOD:00059 , N-acetyl-L-serine MOD:00060 , N,O-diacetylated L-serine MOD:00648 , N-acetyl-L-threonine MOD:00061 , N-acetyl-L-tyrosine MOD:00062 , N-acetyl-L-valine MOD:00063 , N2-acetyl-L-arginine MOD:00359
A	MSE	Parent Component: MET RESID: AA0041 , AA0042 , AA0043 , AA0044 , AA0045 , AA0046 , AA0049 , AA0050 , AA0051 , AA0052 , AA0053 , AA0054 , AA0354

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.