1HK5

HUMAN SERUM ALBUMIN MUTANT R218H COMPLEXED WITH THYROXINE (3,3',5,5'-TETRAIODO-L-THYRONINE) and myristic acid (tetradecanoic acid)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1hk5a1	All alpha proteins	Serum albumin-like	Serum albumin-like	Serum albumin-like	Serum albumin	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Serum albumin-like	8033044	3001552	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Serum albumin-like	8033047	3001552	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Serum albumin-like	8033045	3001552	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Serum_albumin	e1hk5A1	A: alpha complex topology	X: Serum albumin-like (From Topology)	H: Serum albumin-like (From Topology)	T: Serum albumin-like	F: Serum_albumin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.246.10	Mainly Alpha	Orthogonal Bundle	Serum Albumin	Chain A, Domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00273	Serum albumin family (Serum_albumin)	Serum albumin family	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	SERUM ALBUMIN	antioxidant activity vitamin binding vitamin B6 binding pyridoxal phosphate binding ion binding binding organic cyclic compound binding anion binding heterocyclic compound binding small molecule binding fatty acid binding organic acid binding lipid binding carboxylic acid binding antioxidant activity vitamin binding vitamin B6 binding pyridoxal phosphate binding ion binding binding organic cyclic compound binding anion binding heterocyclic compound binding small molecule binding fatty acid binding organic acid binding lipid binding carboxylic acid binding monocarboxylic acid binding protein binding exogenous protein binding cation binding transition metal ion binding copper ion binding metal ion binding toxic substance binding macrolide binding enterobactin binding protein-folding chaperone binding DNA binding nucleic acid binding identical protein binding	regulation of biological process regulation of cellular process regulation of mitochondrial depolarization negative regulation of membrane depolarization biological regulation negative regulation of biological process mitochondrial depolarization regulation of membrane depolarization regulation of mitochondrial membrane potential membrane depolarization cellular process regulation of biological quality negative regulation of mitochondrial depolarization regulation of membrane potential regulation of biological process regulation of cellular process regulation of mitochondrial depolarization negative regulation of membrane depolarization biological regulation negative regulation of biological process mitochondrial depolarization regulation of membrane depolarization regulation of mitochondrial membrane potential membrane depolarization cellular process regulation of biological quality negative regulation of mitochondrial depolarization regulation of membrane potential cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus cellular response to stress response to stress response to starvation cellular response to calcium ion starvation cellular response to starvation	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm protein-containing complex blood microparticle extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm protein-containing complex blood microparticle intracellular organelle Golgi apparatus intracellular membrane-bounded organelle endomembrane system membrane-enclosed lumen intracellular organelle lumen endoplasmic reticulum lumen organelle lumen endoplasmic reticulum vesicle lumen intracellular vesicle cytoplasmic vesicle lumen secretory granule lumen cytoplasmic vesicle secretory granule secretory vesicle platelet alpha granule platelet alpha granule lumen nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR020857	Serum albumin, conserved site	Conserved Site
A	IPR000264	ALB/AFP/VDB	Family
A	IPR014760	Serum albumin, N-terminal	Domain
A	IPR020858	Serum albumin-like	Homologous Superfamily
A	IPR021177	Serum albumin/Alpha-fetoprotein/Afamin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P02768	thrombocytopenia pancreatitis Stevens-Johnson syndrome allergic disease angioedema hyperthyroxinemia, familial dysalbuminemic myopathy heart disease hemolytic-uremic syndrome uveitis membranous glomerulonephritis adult acute respiratory distress syndrome nephrotic syndrome glomerulonephritis kidney disease thrombocytopenia pancreatitis Stevens-Johnson syndrome allergic disease angioedema hyperthyroxinemia, familial dysalbuminemic myopathy heart disease hemolytic-uremic syndrome uveitis membranous glomerulonephritis adult acute respiratory distress syndrome nephrotic syndrome glomerulonephritis kidney disease HIV infectious disease echinococcosis hypertensive disorder interstitial nephritis Pain diabetic peripheral angiopathy melancholia urticaria congenital analbuminemia nephrosis keloid serum sickness hepatitis brain disease membranoproliferative glomerulonephritis cardiovascular disease cerebrovascular disorder endogenous depression anuria nephritis congestive heart failure aseptic meningitis azoospermia brain ischemia acute liver failure epilepsy poisoning chronic kidney disease cirrhosis of liver proteinuria influenza coronary artery disease neurodegenerative disease asthma respiratory failure dense deposit disease non-alcoholic fatty liver disease autoimmune disease bone marrow disease hepatitis C virus infection toxic epidermal necrolysis lymphatic system disease breast disease type IV hypersensitivity disease pancreatic intraductal papillary-mucinous neoplasm cancer perennial allergic rhinitis Ehlers-Danlos syndrome, arthrochalasis type peritonitis primary biliary cholangitis chronic obstructive pulmonary disease arthritic joint disease protein-energy malnutrition inborn carbohydrate metabolic disorder gastric neoplasm psoriasis inherited lipid metabolism disorder COVID-19 neurotic disorder atherosclerosis respiratory system disease obesity disorder diabetic kidney disease liver disease diabetic retinopathy brain injury tuberculosis pancreatic ductal adenocarcinoma hereditary diffuse gastric adenocarcinoma breast cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia peripheral neuropathy hyperglycemia muscle tissue disease pneumonia cholestasis esophageal varices primary membranoproliferative glomerulonephritis hypotensive disorder protein-losing enteropathy inflammatory bowel disease dementia heart failure depressive disorder hepatic encephalopathy skin disease stomach disease leukopenia hepatitis B virus infection thrombotic disease lung adenocarcinoma diarrheal disease pancreas disease breast carcinoma type 2 diabetes mellitus malignant pancreatic neoplasm acute kidney failure pancreatic intraductal papillary-mucinous carcinoma hereditary hyperbilirubinemia C1 inhibitor deficiency urinary tract infection drug-induced liver injury varicose disease metabolic acidosis peripheral vascular disease hyperparathyroidism muscular disease anemia extrahepatic cholestasis prostate carcinoma hypoglycemia idiopathic membranous glomerulonephritis nephrosclerosis gastric cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.