1HKM

High resolution crystal structure of human chitinase in complex with demethylallosamidin

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1hkma1	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	(Trans)glycosidases	Type II chitinase	Chitotriosidase	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1hkma2	Alpha and beta proteins (a+b)	FKBP-like	Chitinase insertion domain	Chitinase insertion domain	Chitotriosidase	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	(Trans)glycosidases	8033020	3000313	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	(Trans)glycosidases	8033020	3000313	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Chitinase insertion domain	8033021	3000666	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	GH18_chitolectin_chitotriosidase	e1hkmA1	A: a+b two layers	X: FKBP-like	H: Chitinase insertion domain (From Topology)	T: Chitinase insertion domain	F: GH18_chitolectin_chitotriosidase	ECOD (1.6)
A	Glyco_hydro_18	e1hkmA2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glyco_hydro_18	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
A	3.10.50.10	Alpha Beta	Roll	Chitinase A	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00704	Glycosyl hydrolases family 18 (Glyco_hydro_18)	Glycosyl hydrolases family 18	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CHITOTRIOSIDASE	chitinase activity hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity catalytic activity endochitinase activity chitin binding binding carbohydrate derivative binding	response to stimulus immune response immune system process biological process involved in interspecies interaction between organisms response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus carbohydrate derivative catabolic process catabolic process carbohydrate derivative metabolic process chitin metabolic process aminoglycan catabolic process response to stimulus immune response immune system process biological process involved in interspecies interaction between organisms response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus carbohydrate derivative catabolic process catabolic process carbohydrate derivative metabolic process chitin metabolic process aminoglycan catabolic process macromolecule catabolic process glucosamine-containing compound catabolic process amino sugar catabolic process aminoglycan metabolic process amino sugar metabolic process metabolic process cellular process macromolecule metabolic process chitin catabolic process glucosamine-containing compound metabolic process carbohydrate metabolic process polysaccharide metabolic process polysaccharide catabolic process carbohydrate catabolic process primary metabolic process polysaccharide digestion multicellular organismal process digestion	membrane-bounded organelle intracellular anatomical structure tertiary granule lumen membrane-enclosed lumen intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen tertiary granule intracellular organelle cellular anatomical structure organelle lumen cytoplasmic vesicle organelle membrane-bounded organelle intracellular anatomical structure tertiary granule lumen membrane-enclosed lumen intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen tertiary granule intracellular organelle cellular anatomical structure organelle lumen cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle extracellular region vesicle lumen cytoplasmic vesicle lumen secretory granule lumen specific granule lumen specific granule extracellular space lytic vacuole vacuole lysosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036508	Chitin binding domain superfamily	Homologous Superfamily
A	IPR029070	Chitinase insertion domain superfamily	Homologous Superfamily
A	IPR001579	Glycosyl hydrolase family 18, active site	Active Site
A	IPR017853	Glycoside hydrolase superfamily	Homologous Superfamily
A	IPR050314	Glycosyl Hydrolase Family 18	Family
A	IPR001223	Glycoside hydrolase family 18, catalytic domain	Domain
A	IPR011583	Chitinase II/V-like, catalytic domain	Domain
A	IPR002557	Chitin binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q13231	Gaucher disease chronic obstructive pulmonary disease Gaucher Disease, Type 1 head and neck cancer MALT lymphoma sarcoidosis ductal breast carcinoma in situ lung adenocarcinoma non-small cell lung carcinoma lung carcinoma osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.