1HXD
CRYSTAL STRUCTURE OF E. COLI BIOTIN REPRESSOR WITH BOUND BIOTIN
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | Transcriptional regulator domain | 8002578 | 3000121 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Winged helix DNA-binding domain | 8002573 | 3000034 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Class II aaRS and biotin synthetases | 8002576 | 3000058 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Class II aaRS and biotin synthetases | 8002576 | 3000058 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Winged helix DNA-binding domain | 8002573 | 3000034 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Transcriptional regulator domain | 8002578 | 3000121 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | BPL_C | e1hxdA1 | A: beta barrels | X: SH3 | H: SH3 | T: SH3 | F: BPL_C | ECOD (1.6) |
A | HTH_11 | e1hxdA2 | A: alpha arrays | X: HTH | H: HTH | T: winged | F: HTH_11 | ECOD (1.6) |
A | BPL_LplA_LipB | e1hxdA3 | A: a+b three layers | X: Class II aaRS and biotin synthetases (From Topology) | H: Class II aaRS and biotin synthetases (From Topology) | T: Class II aaRS and biotin synthetases | F: BPL_LplA_LipB | ECOD (1.6) |
B | BPL_C | e1hxdB1 | A: beta barrels | X: SH3 | H: SH3 | T: SH3 | F: BPL_C | ECOD (1.6) |
B | HTH_11 | e1hxdB2 | A: alpha arrays | X: HTH | H: HTH | T: winged | F: HTH_11 | ECOD (1.6) |
B | BPL_LplA_LipB | e1hxdB3 | A: a+b three layers | X: Class II aaRS and biotin synthetases (From Topology) | H: Class II aaRS and biotin synthetases (From Topology) | T: Class II aaRS and biotin synthetases | F: BPL_LplA_LipB | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 1.10.10.10 | Mainly Alpha | Orthogonal Bundle | Arc Repressor Mutant, subunit A | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | CATH (4.3.0) |
A | 3.30.930.10 | Alpha Beta | 2-Layer Sandwich | BirA Bifunctional Protein | domain 2 | CATH (4.3.0) |
A | 2.30.30.100 | Mainly Beta | Roll | SH3 type barrels. | CATH (4.3.0) | |
B | 1.10.10.10 | Mainly Alpha | Orthogonal Bundle | Arc Repressor Mutant, subunit A | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | CATH (4.3.0) |
B | 3.30.930.10 | Alpha Beta | 2-Layer Sandwich | BirA Bifunctional Protein | domain 2 | CATH (4.3.0) |
B | 2.30.30.100 | Mainly Beta | Roll | SH3 type barrels. | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF08279 | HTH domain (HTH_11) | HTH domain | This family includes helix-turn-helix domains in a wide variety of proteins. | Domain | |
PF03099 | Biotin/lipoate A/B protein ligase family (BPL_LplA_LipB) | Biotin/lipoate A/B protein ligase family | This family includes biotin protein ligase, lipoate-protein ligase A and B. Biotin is covalently attached at the active site of certain enzymes that transfer carbon dioxide from bicarbonate to organic acids to form cellular metabolites. Biotin prot ... | Domain | |
PF02237 | Biotin protein ligase C terminal domain (BPL_C) | Biotin protein ligase C terminal domain | The function of this structural domain is unknown. It is found to the C terminus of the biotin protein ligase catalytic domain Pfam:PF01317. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR004408 | Biotin--acetyl-CoA-carboxylase ligase | Family | |
IPR045864 | Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL) | Homologous Superfamily | |
IPR036388 | Winged helix-like DNA-binding domain superfamily | Homologous Superfamily | |
IPR008988 | Transcriptional repressor, C-terminal | Homologous Superfamily | |
IPR036390 | Winged helix DNA-binding domain superfamily | Homologous Superfamily | |
IPR004143 | Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain | Domain | |
IPR013196 | Helix-turn-helix, type 11 | Domain | |
IPR030855 | Bifunctional ligase/repressor BirA | Family | |
IPR003142 | Biotin protein ligase, C-terminal | Domain | |
IPR004409 | Biotin operon repressor, helix-turn-helix domain | Domain |