Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
C [auth L]d1hzhl1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin light chain kappa variable domain, VL-kappa human (Homo sapiens ) [TaxId: 9606 ], Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
C [auth L]d1hzhl2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin light chain kappa constant domain, CL-kappa human (Homo sapiens ) [TaxId: 9606 ], Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
D [auth M]d1hzhm1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin light chain kappa variable domain, VL-kappa human (Homo sapiens ) [TaxId: 9606 ], Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
D [auth M]d1hzhm2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin light chain kappa constant domain, CL-kappa human (Homo sapiens ) [TaxId: 9606 ], Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
A [auth H]d1hzhh1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin heavy chain variable domain, VH human (Homo sapiens ) [TaxId: 9606 ], Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
A [auth H]d1hzhh2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma human (Homo sapiens ) [TaxId: 9606 ], Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
A [auth H]d1hzhh3 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin heavy chain gamma constant domain 2, CH2-gamma human (Homo sapiens ) [TaxId: 9606 ], Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
A [auth H]d1hzhh4 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin heavy chain gamma constant domain 3, CH3-gamma human (Homo sapiens ) [TaxId: 9606 ], Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
B [auth K]d1hzhk1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin heavy chain variable domain, VH human (Homo sapiens ) [TaxId: 9606 ], Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
B [auth K]d1hzhk2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma human (Homo sapiens ) [TaxId: 9606 ], Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
B [auth K]d1hzhk3 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin heavy chain gamma constant domain 2, CH2-gamma human (Homo sapiens ) [TaxId: 9606 ], Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
B [auth K]d1hzhk4 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) Immunoglobulin heavy chain gamma constant domain 3, CH3-gamma human (Homo sapiens ) [TaxId: 9606 ], Human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
C [auth L]SCOP2 FamilyAntibody constant domains 8091526 4007745 SCOP2 (2022-06-29)
C [auth L]SCOP2 FamilyAntibody variable domains 8091528 4007744 SCOP2 (2022-06-29)
C [auth L]SCOP2 SuperfamilyImmunoglobulin (Ig) domain-like 8091527 3000071 SCOP2 (2022-06-29)
C [auth L]SCOP2 SuperfamilyImmunoglobulin (Ig) domain-like 8091529 3000071 SCOP2 (2022-06-29)
D [auth M]SCOP2B SuperfamilyImmunoglobulin (Ig) domain-like 8091527 3000071 SCOP2B (2022-06-29)
A [auth H]SCOP2 FamilyAntibody constant domains 8091518 4007745 SCOP2 (2022-06-29)
A [auth H]SCOP2 FamilyAntibody constant domains 8091520 4007745 SCOP2 (2022-06-29)
A [auth H]SCOP2 FamilyAntibody constant domains 8091522 4007745 SCOP2 (2022-06-29)
A [auth H]SCOP2 FamilyAntibody variable domains 8091524 4007744 SCOP2 (2022-06-29)
A [auth H]SCOP2 SuperfamilyImmunoglobulin (Ig) domain-like 8091525 3000071 SCOP2 (2022-06-29)
A [auth H]SCOP2 SuperfamilyImmunoglobulin (Ig) domain-like 8091521 3000071 SCOP2 (2022-06-29)
A [auth H]SCOP2 SuperfamilyImmunoglobulin (Ig) domain-like 8091523 3000071 SCOP2 (2022-06-29)
A [auth H]SCOP2 SuperfamilyImmunoglobulin (Ig) domain-like 8091519 3000071 SCOP2 (2022-06-29)
B [auth K]SCOP2B SuperfamilyImmunoglobulin (Ig) domain-like 8091523 3000071 SCOP2B (2022-06-29)
B [auth K]SCOP2B SuperfamilyImmunoglobulin (Ig) domain-like 8091521 3000071 SCOP2B (2022-06-29)
B [auth K]SCOP2B SuperfamilyImmunoglobulin (Ig) domain-like 8091519 3000071 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
C [auth L]C1-set_4e1hzhL2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
C [auth L]V-sete1hzhL1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)
D [auth M]C1-set_4e1hzhM2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_4ECOD (1.6)
D [auth M]V-sete1hzhM1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)
A [auth H]C1-sete1hzhH7 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-setECOD (1.6)
A [auth H]V-set_8e1hzhH5 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
A [auth H]C1-set_1e1hzhH8 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)
B [auth K]C1-sete1hzhK3 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-setECOD (1.6)
B [auth K]V-set_8e1hzhK1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_8ECOD (1.6)
B [auth K]C1-set_1e1hzhK4 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
C [auth L]2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
D [auth M]2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
A [auth H]2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
B [auth K]2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

ChainProtein NameDescriptionOrganism NameGene Allele Name(s)Domain Name(s)Receptor TypeReceptor DescriptionProvenance Source
C [auth L],
D [auth M]
b12 mAb, anti-gp120 CD4 binding site (CD4bs) [HIV-1], L-KAPPA Homo sapiens (human) IGKV3-20*01, IGKJ2*01, IGKC*01 V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA IG IG-GAMMA-1_KAPPA IMGT (202443-0)
A [auth H],
B [auth K]
b12 mAb, anti-gp120 CD4 binding site (CD4bs) [HIV-1], H-GAMMA-1 Homo sapiens (human) IGHV1-3*01, IGHJ6*03, IGHG1*01, IGHG1*02, IGHG1*04, IGHG1*05 V-DOMAIN VH, C-DOMAIN CH1, C-DOMAIN CH2, C-DOMAIN CH3 IG IG-GAMMA-1_KAPPA IMGT (202443-0)

SAbDab Antibody Annotation SAbDab Database Homepage

ChainChain ClassChain SubclassChain TypeAntigen Name(s) Provenance Source
C [auth L],
D [auth M]
Light ChainIGKV3 Kappa-SAbDab (2024-11-01)
A [auth H],
B [auth K]
Heavy ChainIGHV1 --SAbDab (2024-11-01)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
C [auth L],
D [auth M]
PF07654Immunoglobulin C1-set domain (C1-set)Immunoglobulin C1-set domain- Domain
A [auth H],
B [auth K]
PF07654Immunoglobulin C1-set domain (C1-set)Immunoglobulin C1-set domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
C [auth L],
D [auth M]
IMMUNOGLOBULIN LIGHT CHAIN,Uncharacterized protein
A [auth H],
B [auth K]
IMMUNOGLOBULIN HEAVY CHAIN