1HZH
CRYSTAL STRUCTURE OF THE INTACT HUMAN IGG B12 WITH BROAD AND POTENT ACTIVITY AGAINST PRIMARY HIV-1 ISOLATES: A TEMPLATE FOR HIV VACCINE DESIGN
External Resource: Annotation
- Domain Annotation: SCOP/SCOPe Classification
- Domain Annotation: SCOP2 Classification
- Domain Annotation: ECOD Classification
- Domain Annotation: CATH
- IMGT Antibody Annotation
- SAbDab Antibody Annotation
- Protein Family Annotation
- Gene Ontology: Gene Product Annotation
- InterPro: Protein Family Classification
- Pharos: Disease Associations
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
C [auth L] | SCOP2 Family | Antibody constant domains | 8091526 | 4007745 | SCOP2 (2022-06-29) |
C [auth L] | SCOP2 Family | Antibody variable domains | 8091528 | 4007744 | SCOP2 (2022-06-29) |
C [auth L] | SCOP2 Superfamily | Immunoglobulin (Ig) domain-like | 8091527 | 3000071 | SCOP2 (2022-06-29) |
C [auth L] | SCOP2 Superfamily | Immunoglobulin (Ig) domain-like | 8091529 | 3000071 | SCOP2 (2022-06-29) |
D [auth M] | SCOP2B Superfamily | Immunoglobulin (Ig) domain-like | 8091527 | 3000071 | SCOP2B (2022-06-29) |
A [auth H] | SCOP2 Family | Antibody constant domains | 8091518 | 4007745 | SCOP2 (2022-06-29) |
A [auth H] | SCOP2 Family | Antibody constant domains | 8091520 | 4007745 | SCOP2 (2022-06-29) |
A [auth H] | SCOP2 Family | Antibody constant domains | 8091522 | 4007745 | SCOP2 (2022-06-29) |
A [auth H] | SCOP2 Family | Antibody variable domains | 8091524 | 4007744 | SCOP2 (2022-06-29) |
A [auth H] | SCOP2 Superfamily | Immunoglobulin (Ig) domain-like | 8091525 | 3000071 | SCOP2 (2022-06-29) |
A [auth H] | SCOP2 Superfamily | Immunoglobulin (Ig) domain-like | 8091521 | 3000071 | SCOP2 (2022-06-29) |
A [auth H] | SCOP2 Superfamily | Immunoglobulin (Ig) domain-like | 8091523 | 3000071 | SCOP2 (2022-06-29) |
A [auth H] | SCOP2 Superfamily | Immunoglobulin (Ig) domain-like | 8091519 | 3000071 | SCOP2 (2022-06-29) |
B [auth K] | SCOP2B Superfamily | Immunoglobulin (Ig) domain-like | 8091523 | 3000071 | SCOP2B (2022-06-29) |
B [auth K] | SCOP2B Superfamily | Immunoglobulin (Ig) domain-like | 8091521 | 3000071 | SCOP2B (2022-06-29) |
B [auth K] | SCOP2B Superfamily | Immunoglobulin (Ig) domain-like | 8091519 | 3000071 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
C [auth L] | C1-set_4 | e1hzhL2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_4 | ECOD (1.6) |
C [auth L] | V-set | e1hzhL1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set | ECOD (1.6) |
D [auth M] | C1-set_4 | e1hzhM2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_4 | ECOD (1.6) |
D [auth M] | V-set | e1hzhM1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set | ECOD (1.6) |
A [auth H] | C1-set | e1hzhH7 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set | ECOD (1.6) |
A [auth H] | V-set_8 | e1hzhH5 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
A [auth H] | C1-set_1 | e1hzhH8 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_1 | ECOD (1.6) |
B [auth K] | C1-set | e1hzhK3 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set | ECOD (1.6) |
B [auth K] | V-set_8 | e1hzhK1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
B [auth K] | C1-set_1 | e1hzhK4 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_1 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
C [auth L] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
D [auth M] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
A [auth H] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
B [auth K] | 2.60.40.10 | Mainly Beta | Sandwich | Immunoglobulin-like | Immunoglobulins | CATH (4.3.0) |
IMGT Antibody Annotation IMGT Database Homepage
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
---|---|---|---|---|---|---|---|---|
C [auth L], D [auth M] | b12 mAb, anti-gp120 CD4 binding site (CD4bs) [HIV-1], | L-KAPPA | Homo sapiens (human) | IGKV3-20*01, IGKJ2*01, IGKC*01 | V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA | IG | IG-GAMMA-1_KAPPA | IMGT (202443-0) |
A [auth H], B [auth K] | b12 mAb, anti-gp120 CD4 binding site (CD4bs) [HIV-1], | H-GAMMA-1 | Homo sapiens (human) | IGHV1-3*01, IGHJ6*03, IGHG1*01, IGHG1*02, IGHG1*04, IGHG1*05 | V-DOMAIN VH, C-DOMAIN CH1, C-DOMAIN CH2, C-DOMAIN CH3 | IG | IG-GAMMA-1_KAPPA | IMGT (202443-0) |
SAbDab Antibody Annotation SAbDab Database Homepage
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
---|---|---|---|---|---|
C [auth L], D [auth M] | Light Chain | IGKV3 | Kappa | - | SAbDab (2024-11-01) |
A [auth H], B [auth K] | Heavy Chain | IGHV1 | - | - | SAbDab (2024-11-01) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
C [auth L], D [auth M] | PF07654 | Immunoglobulin C1-set domain (C1-set) | Immunoglobulin C1-set domain | - | Domain |
A [auth H], B [auth K] | PF07654 | Immunoglobulin C1-set domain (C1-set) | Immunoglobulin C1-set domain | - | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
C [auth L], D [auth M] | IPR036179 | Immunoglobulin-like domain superfamily | Homologous Superfamily |
C [auth L], D [auth M] | IPR050160 | Major Histocompatibility Complex/Immunoglobulin | Family |
C [auth L], D [auth M] | IPR003597 | Immunoglobulin C1-set | Domain |
C [auth L], D [auth M] | IPR013783 | Immunoglobulin-like fold | Homologous Superfamily |
C [auth L], D [auth M] | IPR007110 | Immunoglobulin-like domain | Domain |
C [auth L], D [auth M] | IPR003006 | Immunoglobulin/major histocompatibility complex, conserved site | Conserved Site |
A [auth H], B [auth K] | IPR036179 | Immunoglobulin-like domain superfamily | Homologous Superfamily |
A [auth H], B [auth K] | IPR050380 | Immune Recognition and Response Modulators | Family |
A [auth H], B [auth K] | IPR003597 | Immunoglobulin C1-set | Domain |
A [auth H], B [auth K] | IPR013783 | Immunoglobulin-like fold | Homologous Superfamily |
A [auth H], B [auth K] | IPR007110 | Immunoglobulin-like domain | Domain |
A [auth H], B [auth K] | IPR003006 | Immunoglobulin/major histocompatibility complex, conserved site | Conserved Site |