1K0E

THE CRYSTAL STRUCTURE OF AMINODEOXYCHORISMATE SYNTHASE FROM FORMATE GROWN CRYSTALS

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1k0ea_	Alpha and beta proteins (a+b)	ADC synthase	ADC synthase	ADC synthase	P-aminobenzoate synthase component I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1k0eb_	Alpha and beta proteins (a+b)	ADC synthase	ADC synthase	ADC synthase	P-aminobenzoate synthase component I	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ADC synthase	8037733	3001093	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ADC synthase	8037733	3001093	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Chorismate_bind	e1k0eA1	A: a+b duplicates or obligate multimers	X: ADC synthase (From Topology)	H: ADC synthase (From Topology)	T: ADC synthase	F: Chorismate_bind	ECOD (1.6)
B	Chorismate_bind	e1k0eB1	A: a+b duplicates or obligate multimers	X: ADC synthase (From Topology)	H: ADC synthase (From Topology)	T: ADC synthase	F: Chorismate_bind	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.60.120.10	Alpha Beta	4-Layer Sandwich	Anthranilate synthase	Anthranilate synthase	CATH (4.3.0)
B	3.60.120.10	Alpha Beta	4-Layer Sandwich	Anthranilate synthase	Anthranilate synthase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00425	chorismate binding enzyme (Chorismate_bind)	chorismate binding enzyme	-	Family
A, B	PF04715	Anthranilate synthase component I, N terminal region (Anth_synt_I_N)	Anthranilate synthase component I, N terminal region	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	p-aminobenzoate synthase component I	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding protein heterodimerization activity protein binding protein dimerization activity organic acid binding tryptophan binding amino acid binding organic cyclic compound binding anion binding cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding protein heterodimerization activity protein binding protein dimerization activity organic acid binding tryptophan binding amino acid binding organic cyclic compound binding anion binding carboxylic acid binding heterocyclic compound binding transferase activity, transferring nitrogenous groups transaminase activity transferase activity catalytic activity 4-amino-4-deoxychorismate synthase activity	oxoacid metabolic process indole-containing compound metabolic process amino acid metabolic process organic acid biosynthetic process organic acid metabolic process alpha-amino acid metabolic process carboxylic acid biosynthetic process biogenic amine biosynthetic process tryptophan biosynthetic process indole-containing compound biosynthetic process indolalkylamine metabolic process small molecule metabolic process indolalkylamine biosynthetic process aromatic amino acid family biosynthetic process oxoacid metabolic process indole-containing compound metabolic process amino acid metabolic process organic acid biosynthetic process organic acid metabolic process alpha-amino acid metabolic process carboxylic acid biosynthetic process biogenic amine biosynthetic process tryptophan biosynthetic process indole-containing compound biosynthetic process indolalkylamine metabolic process small molecule metabolic process indolalkylamine biosynthetic process aromatic amino acid family biosynthetic process aromatic amino acid metabolic process small molecule biosynthetic process carboxylic acid metabolic process primary metabolic process amine metabolic process amino acid biosynthetic process biosynthetic process amine biosynthetic process metabolic process cellular process biogenic amine metabolic process alpha-amino acid biosynthetic process benzene-containing compound metabolic process monocarboxylic acid biosynthetic process para-aminobenzoic acid biosynthetic process para-aminobenzoic acid metabolic process monocarboxylic acid metabolic process modified amino acid biosynthetic process vitamin biosynthetic process amide metabolic process water-soluble vitamin metabolic process folic acid metabolic process dicarboxylic acid biosynthetic process folic acid biosynthetic process folic acid-containing compound biosynthetic process water-soluble vitamin biosynthetic process dicarboxylic acid metabolic process modified amino acid metabolic process amide biosynthetic process vitamin metabolic process folic acid-containing compound metabolic process pteridine-containing compound biosynthetic process pteridine-containing compound metabolic process tetrahydrofolate biosynthetic process tetrahydrofolate metabolic process	protein-containing complex catalytic complex aminodeoxychorismate synthase complex intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR005802	Aminodeoxychorismate synthase, component I	Family
A, B	IPR019999	Anthranilate synthase component I-like	Family
A, B	IPR005801	ADC synthase	Homologous Superfamily
A, B	IPR015890	Chorismate-utilising enzyme, C-terminal	Domain
A, B	IPR006805	Anthranilate synthase component I, N-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.