1KRM

Crystal structure of bovine adenosine deaminase complexed with 6-hydroxyl-1,6-dihydropurine riboside

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1krma_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Metallo-dependent hydrolases	Adenosine/AMP deaminase	Adenosine deaminase (ADA)	(Bos taurus ) [TaxId: 9913 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Metallo-dependent hydrolases	8032391	3000428	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	A_deaminase	e1krmA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: A_deaminase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.20.140	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Metal-dependent hydrolases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00962	Adenosine deaminase (A_deaminase)	Adenosine deaminase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	adenosine deaminase	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines adenosine deaminase activity hydrolase activity catalytic activity deaminase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 2'-deoxyadenosine deaminase activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding	multicellular organismal process T cell activation immune system process cell activation cellular process lymphocyte activation leukocyte activation nucleoside phosphate metabolic process purine ribonucleoside monophosphate biosynthetic process primary metabolic process nucleobase-containing compound biosynthetic process nucleoside monophosphate biosynthetic process nucleobase-containing compound metabolic process purine nucleoside monophosphate biosynthetic process multicellular organismal process T cell activation immune system process cell activation cellular process lymphocyte activation leukocyte activation nucleoside phosphate metabolic process purine ribonucleoside monophosphate biosynthetic process primary metabolic process nucleobase-containing compound biosynthetic process nucleoside monophosphate biosynthetic process nucleobase-containing compound metabolic process purine nucleoside monophosphate biosynthetic process purine ribonucleoside monophosphate metabolic process biosynthetic process ribonucleoside monophosphate metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process organophosphate biosynthetic process purine nucleoside monophosphate metabolic process phosphate-containing compound metabolic process nucleoside phosphate biosynthetic process metabolic process small molecule metabolic process ribonucleoside monophosphate biosynthetic process nucleoside monophosphate metabolic process phosphorus metabolic process purine-containing compound salvage purine nucleobase metabolic process nucleobase biosynthetic process purine nucleobase biosynthetic process hypoxanthine biosynthetic process purine-containing compound metabolic process hypoxanthine metabolic process purine-containing compound biosynthetic process nucleobase metabolic process hypoxanthine salvage purine nucleobase salvage cellular metabolic compound salvage cell adhesion glycosyl compound metabolic process catabolic process purine nucleoside catabolic process carbohydrate derivative metabolic process purine ribonucleoside metabolic process carbohydrate derivative catabolic process adenosine catabolic process glycosyl compound catabolic process purine-containing compound catabolic process nucleoside metabolic process nucleobase-containing compound catabolic process adenosine metabolic process nucleobase-containing small molecule catabolic process nucleoside catabolic process small molecule catabolic process ribonucleoside catabolic process purine nucleoside metabolic process purine ribonucleoside catabolic process ribonucleoside metabolic process cellular response to stimulus regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of biological process regulation of signal transduction negative regulation of G protein-coupled receptor signaling pathway negative regulation of cell communication cell communication negative regulation of cellular process signal transduction regulation of G protein-coupled receptor signaling pathway regulation of biological process regulation of signaling purinergic nucleotide receptor signaling pathway cell surface receptor signaling pathway negative regulation of response to stimulus G protein-coupled purinergic receptor signaling pathway biological regulation negative regulation of signal transduction regulation of adenosine receptor signaling pathway regulation of response to stimulus regulation of cell communication G protein-coupled receptor signaling pathway negative regulation of adenosine receptor signaling pathway G protein-coupled adenosine receptor signaling pathway nucleotide metabolic process nucleoside biosynthetic process carbohydrate derivative biosynthetic process glycosyl compound biosynthetic process inosine metabolic process small molecule biosynthetic process purine ribonucleoside biosynthetic process ribonucleoside biosynthetic process nucleobase-containing small molecule biosynthetic process inosine biosynthetic process purine nucleoside biosynthetic process	membrane-bounded organelle vesicle lumen intracellular anatomical structure membrane-enclosed lumen intracellular vesicle cytoplasmic vesicle lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen cytoplasmic vesicle organelle cytoplasm membrane-bounded organelle vesicle lumen intracellular anatomical structure membrane-enclosed lumen intracellular vesicle cytoplasmic vesicle lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen cytoplasmic vesicle organelle cytoplasm vesicle cell periphery cell surface membrane plasma membrane external side of plasma membrane side of membrane cytosol anchoring junction cell junction lytic vacuole vacuole lysosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001365	Adenosine deaminase domain	Domain
A	IPR032466	Metal-dependent hydrolase	Homologous Superfamily
A	IPR028893	Adenosine deaminase	Family
A	IPR006330	Adenosine/adenine deaminase	Family
A	IPR006650	Adenosine/AMP deaminase active site	Active Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.