1KXG

The 2.0 Ang Resolution Structure of BLyS, B Lymphocyte Stimulator.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1kxga_	All beta proteins	TNF-like	TNF-like	TNF-like	Soluble part of TALL-1, sTALL-1 (BAFF)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1kxgb_	All beta proteins	TNF-like	TNF-like	TNF-like	Soluble part of TALL-1, sTALL-1 (BAFF)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1kxgc_	All beta proteins	TNF-like	TNF-like	TNF-like	Soluble part of TALL-1, sTALL-1 (BAFF)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1kxgd_	All beta proteins	TNF-like	TNF-like	TNF-like	Soluble part of TALL-1, sTALL-1 (BAFF)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d1kxge_	All beta proteins	TNF-like	TNF-like	TNF-like	Soluble part of TALL-1, sTALL-1 (BAFF)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d1kxgf_	All beta proteins	TNF-like	TNF-like	TNF-like	Soluble part of TALL-1, sTALL-1 (BAFF)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	TNF-like	8028337	4000294	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	TNF-like	8040716	3000061	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	TNF-like	8040716	3000061	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	TNF-like	8040716	3000061	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	TNF-like	8040716	3000061	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	TNF-like	8040716	3000061	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	TNF-like	8040716	3000061	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	TNF	e1kxgA1	A: beta sandwiches	X: jelly-roll	H: TNF-like (From Topology)	T: TNF-like	F: TNF	ECOD (1.6)
B	TNF	e1kxgB1	A: beta sandwiches	X: jelly-roll	H: TNF-like (From Topology)	T: TNF-like	F: TNF	ECOD (1.6)
C	TNF	e1kxgC1	A: beta sandwiches	X: jelly-roll	H: TNF-like (From Topology)	T: TNF-like	F: TNF	ECOD (1.6)
D	TNF	e1kxgD1	A: beta sandwiches	X: jelly-roll	H: TNF-like (From Topology)	T: TNF-like	F: TNF	ECOD (1.6)
E	TNF	e1kxgE1	A: beta sandwiches	X: jelly-roll	H: TNF-like (From Topology)	T: TNF-like	F: TNF	ECOD (1.6)
F	TNF	e1kxgF1	A: beta sandwiches	X: jelly-roll	H: TNF-like (From Topology)	T: TNF-like	F: TNF	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.40	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
B	2.60.120.40	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
C	2.60.120.40	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
D	2.60.120.40	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
E	2.60.120.40	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)
F	2.60.120.40	Mainly Beta	Sandwich	Jelly Rolls		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00229	TNF(Tumour Necrosis Factor) family (TNF)	TNF(Tumour Necrosis Factor) family	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	B lymphocyte stimulator	protein binding binding signaling receptor binding molecular function activator activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity cytokine activity cytokine receptor binding tumor necrosis factor receptor superfamily binding tumor necrosis factor receptor binding	multicellular organismal process regulation of cellular process regulation of leukocyte activation positive regulation of biological process regulation of cell activation lymphocyte activation leukocyte activation positive regulation of lymphocyte activation positive regulation of cell activation regulation of B cell activation positive regulation of leukocyte activation regulation of multicellular organismal process regulation of immune system process positive regulation of immune system process multicellular organismal process regulation of cellular process regulation of leukocyte activation positive regulation of biological process regulation of cell activation lymphocyte activation leukocyte activation positive regulation of lymphocyte activation positive regulation of cell activation regulation of B cell activation positive regulation of leukocyte activation regulation of multicellular organismal process regulation of immune system process positive regulation of immune system process positive regulation of cellular process regulation of biological process B cell costimulation B cell activation cell activation biological regulation positive regulation of B cell activation immune system process lymphocyte costimulation positive regulation of multicellular organismal process cellular process regulation of lymphocyte activation developmental process skin development animal organ development anatomical structure development B cell homeostasis multicellular organismal-level homeostasis leukocyte homeostasis homeostatic process homeostasis of number of cells lymphocyte homeostasis adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of germinal center formation response to stimulus regulation of developmental process positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of germinal center formation positive regulation of response to stimulus positive regulation of developmental process regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of immune response germinal center formation positive regulation of adaptive immune response regulation of anatomical structure morphogenesis immune response regulation of adaptive immune response adaptive immune response anatomical structure morphogenesis regulation of response to stimulus anatomical structure formation involved in morphogenesis regulation of immune response cellular response to stimulus signaling signal transduction cell communication cell population proliferation B cell proliferation leukocyte proliferation mononuclear cell proliferation lymphocyte proliferation T cell activation T cell proliferation cell surface receptor signaling pathway response to cytokine cytokine-mediated signaling pathway response to peptide cellular response to tumor necrosis factor response to chemical tumor necrosis factor-mediated signaling pathway cellular response to cytokine stimulus response to tumor necrosis factor positive regulation of leukocyte cell-cell adhesion leukocyte cell-cell adhesion positive regulation of cell-cell adhesion cell adhesion cell-cell adhesion regulation of cell-cell adhesion positive regulation of T cell activation positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation regulation of leukocyte cell-cell adhesion T cell costimulation positive regulation of cell population proliferation positive regulation of B cell proliferation regulation of B cell proliferation positive regulation of mononuclear cell proliferation regulation of lymphocyte proliferation regulation of leukocyte proliferation positive regulation of lymphocyte proliferation regulation of cell population proliferation positive regulation of leukocyte proliferation regulation of mononuclear cell proliferation transitional one stage B cell differentiation cellular developmental process immature B cell differentiation hemopoiesis cell development mononuclear cell differentiation lymphocyte differentiation transitional stage B cell differentiation B cell differentiation cell differentiation leukocyte differentiation positive regulation of T cell proliferation regulation of T cell proliferation	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane cell periphery plasma membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle cytoplasm anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane cell periphery plasma membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle cytoplasm extracellular region perinuclear region of cytoplasm extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR008983	Tumour necrosis factor-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR051748	Tumor Necrosis Factor Ligand Superfamily	Family
A, B, C, D, E A, B, C, D, E, F	IPR006052	Tumour necrosis factor domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: Q9Y275	multiple sclerosis ovarian cancer sarcoidosis systemic lupus erythematosus arthritic joint disease breast cancer cystic fibrosis glioblastoma interstitial cystitis large cell medulloblastoma medulloblastoma non-small cell lung carcinoma pancreatic ductal adenocarcinoma Sjogren syndrome tuberculosis multiple sclerosis ovarian cancer sarcoidosis systemic lupus erythematosus arthritic joint disease breast cancer cystic fibrosis glioblastoma interstitial cystitis large cell medulloblastoma medulloblastoma non-small cell lung carcinoma pancreatic ductal adenocarcinoma Sjogren syndrome tuberculosis astrocytic tumor chronic obstructive pulmonary disease Duchenne muscular dystrophy head and neck cancer invasive ductal breast carcinoma lung carcinoma Mood Disorders osteosarcoma pilocytic astrocytoma subependymal giant cell astrocytoma ulcerative colitis autoimmune disease Crohn disease gastric carcinoma hematologic disease juvenile dermatomyositis malignant glioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.