Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad1kzja_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Bd1kzjb_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Cd1kzjc_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Dd1kzjd_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Ed1kzje_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)
Fd1kzjf_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase (Escherichia coli ) [TaxId: 562 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8041736 3000544 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8041736 3000544 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8041736 3000544 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8041736 3000544 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8041736 3000544 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8041736 3000544 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AThymidylat_synte1kzjA1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
BThymidylat_synte1kzjB1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
CThymidylat_synte1kzjC1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
DThymidylat_synte1kzjD1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
EThymidylat_synte1kzjE1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
FThymidylat_synte1kzjF1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.30.572.10 Alpha Beta 2-Layer Sandwich Thymidylate Synthase Chain ACATH (4.3.0)
B3.30.572.10 Alpha Beta 2-Layer Sandwich Thymidylate Synthase Chain ACATH (4.3.0)
C3.30.572.10 Alpha Beta 2-Layer Sandwich Thymidylate Synthase Chain ACATH (4.3.0)
D3.30.572.10 Alpha Beta 2-Layer Sandwich Thymidylate Synthase Chain ACATH (4.3.0)
E3.30.572.10 Alpha Beta 2-Layer Sandwich Thymidylate Synthase Chain ACATH (4.3.0)
F3.30.572.10 Alpha Beta 2-Layer Sandwich Thymidylate Synthase Chain ACATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF00303Thymidylate synthase (Thymidylat_synt)Thymidylate synthaseThis is a family of proteins that are flavin-dependent thymidylate synthases.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
Thymidylate synthase

InterPro: Protein Family Classification InterPro Database Homepage

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
A, B, C, D, E
CXM Parent Component: MET

RESIDAA0363 , AA0493

PSI-MOD :  N-carboxy-L-methionine MOD:00368 , N-(dihydroxymethyl)-L-methionine (fMet) MOD:01446 , N-(dihydroxymethyl)-L-methionine (Met) MOD:01447