Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyLipase/lipooxygenase domain (PLAT/LH2 domain) 8042306 3001168 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyLipoxygenase 8042304 3001410 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APLATe1lnhA1 A: beta sandwichesX: jelly-rollH: Lipase/lipooxygenase domain (PLAT/LH2 domain) (From Topology)T: Lipase/lipooxygenase domain (PLAT/LH2 domain)F: PLATECOD (1.6)
ALipoxygenasee1lnhA2 A: alpha bundlesX: Lipoxygenase (From Topology)H: Lipoxygenase (From Topology)T: LipoxygenaseF: LipoxygenaseECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A2.60.60.20 Mainly Beta Sandwich Lipoxygenase-1 PLAT/LH2 domainCATH (4.3.0)
A4.10.375.10 Few Secondary Structures Irregular Lipoxygenase-1 domain 2CATH (4.3.0)
A4.10.372.10 Few Secondary Structures Irregular Lipoxygenase-1 domain 3CATH (4.3.0)
A3.10.450.60 Alpha Beta Roll Nuclear Transport Factor 2 Chain: A,CATH (4.3.0)
A1.20.245.10 Mainly Alpha Up-down Bundle Lipoxygenase-1 domain 5CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00305Lipoxygenase (Lipoxygenase)Lipoxygenase- Domain
PF01477PLAT/LH2 domain (PLAT)PLAT/LH2 domainThis domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain bind ...This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase Pfam:PF01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
LIPOXYGENASE-3

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
linoleate 9S-lipoxygenase  M-CSA #583

Lipoxygenase catalysis is an important aspect of polyunsaturated fatty acid metabolism. The enzyme catalyses the regio- and stereoselective incorporation of molecular oxygen into the methylene interrupted diene system of the substrate to produce a conjugated hydroperoxide product. The peroxidases are intermediates in biosynthetic pathways leading to physiologically potent metabolites in both plants (jasmonates) and animals (leukotrienes and lipoxins). Lipoxygenases contain a distinctive non-heme iron cofactor. Structure is Lipoxygenase 3 from soybean.

Defined by 5 residues: HIS:A-518HIS:A-523HIS:A-709ASN:A-713ILE:A-857
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