This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain bind ...
This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase Pfam:PF01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.
Lipoxygenase catalysis is an important aspect of polyunsaturated fatty acid metabolism. The enzyme catalyses the regio- and stereoselective incorporation of molecular oxygen into the methylene interrupted diene system of the substrate to produce a conjugated hydroperoxide product. The peroxidases are intermediates in biosynthetic pathways leading to physiologically potent metabolites in both plants (jasmonates) and animals (leukotrienes and lipoxins). Lipoxygenases contain a distinctive non-heme iron cofactor. Structure is Lipoxygenase 3 from soybean.
Defined by 5 residues: HIS:A-518HIS:A-523HIS:A-709ASN:A-713ILE:A-857