1LTX
Structure of Rab Escort Protein-1 in complex with Rab geranylgeranyl transferase and isoprenoid
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | L domain-like | 8043989 | 3001010 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Protein prenylyltransferase | 8038637 | 3001312 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Rab geranylgeranyltransferase alpha-subunit, insert domain | 8040730 | 3001017 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Protein prenylyltransferase | 8038637 | 3001312 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Terpenoid cyclases/Protein prenyltransferases | 8040875 | 3001024 | SCOP2B (2022-06-29) |
C [auth R] | SCOP2B Superfamily | Flavoreductase-like | 8044604 | 3000055 | SCOP2B (2022-06-29) |
C [auth R] | SCOP2B Superfamily | GDI isoprenoid-binding domain-like | 8091669 | 3002533 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | RabGGT_insert | e1ltxA1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: RabGGT_insert | ECOD (1.6) |
A | LRR_9 | e1ltxA3 | A: beta duplicates or obligate multimers | X: Single-stranded right-handed beta-helix | H: Leucine-rich repeats (From Topology) | T: Leucine-rich repeats | F: LRR_9 | ECOD (1.6) |
A | PPTA | e1ltxA2 | A: alpha superhelices | X: Repetitive alpha hairpins | H: ARM repeat (From Topology) | T: ARM repeat | F: PPTA | ECOD (1.6) |
B | SQHop_cyclase_C | e1ltxB1 | A: alpha superhelices | X: Repetitive alpha hairpins | H: alpha/alpha toroid (From Topology) | T: alpha/alpha toroid | F: SQHop_cyclase_C | ECOD (1.6) |
C [auth R] | KOG4405 | e1ltxR1 | A: a+b two layers | X: FAD-linked reductases, C-terminal domain-like | H: FAD-linked reductases-C (From Topology) | T: FAD-linked reductases-C | F: KOG4405 | ECOD (1.6) |
C [auth R] | GDI_1st | e1ltxR2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: FAD/NAD(P)-binding domain | F: GDI_1st | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 1.25.40.120 | Mainly Alpha | Alpha Horseshoe | Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat | Protein prenylyltransferase | CATH (4.3.0) |
A | 2.60.40.1130 | Mainly Beta | Sandwich | Immunoglobulin-like | Rab geranylgeranyltransferase alpha-subunit, insert domain | CATH (4.3.0) |
A | 3.80.10.10 | Alpha Beta | Alpha-Beta Horseshoe | Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) | Ribonuclease Inhibitor | CATH (4.3.0) |
B | 1.50.10.20 | Mainly Alpha | Alpha/alpha barrel | Glycosyltransferase | CATH (4.3.0) | |
C [auth R] | 3.50.50.60 | Alpha Beta | 3-Layer(bba) Sandwich | FAD/NAD(P)-binding domain | FAD/NAD(P)-binding domain | CATH (4.3.0) |
C [auth R] | 3.30.519.10 | Alpha Beta | 2-Layer Sandwich | Guanine Nucleotide Dissociation Inhibitor | domain 2 | CATH (4.3.0) |
C [auth R] | 1.10.405.10 | Mainly Alpha | Orthogonal Bundle | Guanine Nucleotide Dissociation Inhibitor | domain 1 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF01239 | Protein prenyltransferase alpha subunit repeat (PPTA) | Protein prenyltransferase alpha subunit repeat | - | Repeat | |
PF07711 | Rab geranylgeranyl transferase alpha-subunit, insert domain (RabGGT_insert) | Rab geranylgeranyl transferase alpha-subunit, insert domain | Rab geranylgeranyl transferase (RabGGT) catalyses the addition of two geranylgeranyl groups to the C-terminal cysteine residues of Rab proteins, which is crucial for membrane association and function of these proteins in intracellular vesicular traff ... | Domain | |
PF00432 | Prenyltransferase and squalene oxidase repeat (Prenyltrans) | Prenyltransferase and squalene oxidase repeat | - | Repeat | |
C [auth R] | PF00996 | GDP dissociation inhibitor (GDI) | GDP dissociation inhibitor | - | Family |
C [auth R] | PF22603 | RAE1/2 domain I, C-terminal region (RAE1_2_domI_C) | RAE1/2 domain I, C-terminal region | This entry represents the C-terminal region of domain I from Rab escort proteins 1/2 (RAE1/2, also known as Rab proteins geranylgeranyltransferase component A 1/2) which are the substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR009087 | Rab geranylgeranyltransferase, alpha subunit, insert-domain | Domain | |
IPR002088 | Protein prenyltransferase, alpha subunit | Repeat | |
IPR032675 | Leucine-rich repeat domain superfamily | Homologous Superfamily | |
IPR036254 | Rab geranylgeranyltransferase, alpha subunit, insert-domain superfamily | Homologous Superfamily | |
IPR045089 | Prenyltransferase subunit beta | Family | |
IPR026873 | Geranylgeranyl transferase type-2 subunit beta | Family | |
IPR001330 | PFTB repeat | Repeat | |
IPR008930 | Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid | Homologous Superfamily | |
C [auth R] | IPR054420 | RAE1/2 domain I, C-terminal region | Domain |
C [auth R] | IPR036188 | FAD/NAD(P)-binding domain superfamily | Homologous Superfamily |
C [auth R] | IPR001738 | Rab protein geranylgeranyltransferase component A | Family |
C [auth R] | IPR018203 | GDP dissociation inhibitor | Family |