1M8P

Crystal Structure of P. chrysogenum ATP Sulfurylase in the T-state

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1m8pa1	All beta proteins	PUA domain-like	PUA domain-like	ATP sulfurylase N-terminal domain	ATP sulfurylase N-terminal domain	(Penicillium chrysogenum ) [TaxId: 5076 ],	SCOPe (2.08)
A	d1m8pa2	Alpha and beta proteins (a/b)	Adenine nucleotide alpha hydrolase-like	Nucleotidylyl transferase	ATP sulfurylase catalytic domain	ATP sulfurylase catalytic domain	(Penicillium chrysogenum ) [TaxId: 5076 ],	SCOPe (2.08)
A	d1m8pa3	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	ATP sulfurylase C-terminal domain	ATP sulfurylase C-terminal domain	(Penicillium chrysogenum ) [TaxId: 5076 ],	SCOPe (2.08)
B	d1m8pb1	All beta proteins	PUA domain-like	PUA domain-like	ATP sulfurylase N-terminal domain	ATP sulfurylase N-terminal domain	(Penicillium chrysogenum ) [TaxId: 5076 ],	SCOPe (2.08)
B	d1m8pb2	Alpha and beta proteins (a/b)	Adenine nucleotide alpha hydrolase-like	Nucleotidylyl transferase	ATP sulfurylase catalytic domain	ATP sulfurylase catalytic domain	(Penicillium chrysogenum ) [TaxId: 5076 ],	SCOPe (2.08)
B	d1m8pb3	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	ATP sulfurylase C-terminal domain	ATP sulfurylase C-terminal domain	(Penicillium chrysogenum ) [TaxId: 5076 ],	SCOPe (2.08)
C	d1m8pc1	All beta proteins	PUA domain-like	PUA domain-like	ATP sulfurylase N-terminal domain	ATP sulfurylase N-terminal domain	(Penicillium chrysogenum ) [TaxId: 5076 ],	SCOPe (2.08)
C	d1m8pc2	Alpha and beta proteins (a/b)	Adenine nucleotide alpha hydrolase-like	Nucleotidylyl transferase	ATP sulfurylase catalytic domain	ATP sulfurylase catalytic domain	(Penicillium chrysogenum ) [TaxId: 5076 ],	SCOPe (2.08)
C	d1m8pc3	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	ATP sulfurylase C-terminal domain	ATP sulfurylase C-terminal domain	(Penicillium chrysogenum ) [TaxId: 5076 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	APS kinase-like	8018698	4003930	SCOP2 (2022-06-29)
A	SCOP2 Family	ATP sulfurylase-like	8018702	4003381	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	P-loop nucleotide/nucleoside kinase-like	8018699	3002021	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Nucleotidylyl transferase	8018703	3001541	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PUA domain-like	8018705	3001015	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	P-loop nucleotide/nucleoside kinase-like	8018699	3002021	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	PUA domain-like	8018705	3001015	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Nucleotidylyl transferase	8018703	3001541	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Nucleotidylyl transferase	8018703	3001541	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	P-loop nucleotide/nucleoside kinase-like	8018699	3002021	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	PUA domain-like	8018705	3001015	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PUA_2	e1m8pA1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PUA domain	F: PUA_2	ECOD (1.6)
A	APS_kinase_1	e1m8pA2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: APS_kinase_1	ECOD (1.6)
A	ATP-sulfurylase	e1m8pA3	A: a/b three-layered sandwiches	X: HUP domain-like	H: HUP domains (From Topology)	T: HUP domains	F: ATP-sulfurylase	ECOD (1.6)
B	PUA_2	e1m8pB1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PUA domain	F: PUA_2	ECOD (1.6)
B	APS_kinase_1	e1m8pB2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: APS_kinase_1	ECOD (1.6)
B	ATP-sulfurylase	e1m8pB3	A: a/b three-layered sandwiches	X: HUP domain-like	H: HUP domains (From Topology)	T: HUP domains	F: ATP-sulfurylase	ECOD (1.6)
C	PUA_2	e1m8pC1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PUA domain	F: PUA_2	ECOD (1.6)
C	APS_kinase_1	e1m8pC2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: APS_kinase_1	ECOD (1.6)
C	ATP-sulfurylase	e1m8pC3	A: a/b three-layered sandwiches	X: HUP domain-like	H: HUP domains (From Topology)	T: HUP domains	F: ATP-sulfurylase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.620	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HUPs	CATH (4.3.0)
A	3.10.400.10	Alpha Beta	Roll	Sulfate adenylyltransferase	Sulfate adenylyltransferase	CATH (4.3.0)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
B	3.40.50.620	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HUPs	CATH (4.3.0)
B	3.10.400.10	Alpha Beta	Roll	Sulfate adenylyltransferase	Sulfate adenylyltransferase	CATH (4.3.0)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
C	3.40.50.620	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HUPs	CATH (4.3.0)
C	3.10.400.10	Alpha Beta	Roll	Sulfate adenylyltransferase	Sulfate adenylyltransferase	CATH (4.3.0)
C	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF14306	PUA-like domain (PUA_2)	PUA-like domain	This PUA like domain is found at the N-terminus of ATP-sulfurylase enzymes.	Domain
A, B, C	PF01747	ATP-sulfurylase (ATP-sulfurylase)	ATP-sulfurylase	This domain is the catalytic domain of ATP-sulfurylase or sulfate adenylyltransferase EC:2.7.7.4 some of which are part of a bifunctional polypeptide chain associated with adenosyl phosphosulphate (APS) kinase Pfam:PF01583. Both enzymes are required ...	This domain is the catalytic domain of ATP-sulfurylase or sulfate adenylyltransferase EC:2.7.7.4 some of which are part of a bifunctional polypeptide chain associated with adenosyl phosphosulphate (APS) kinase Pfam:PF01583. Both enzymes are required for PAPS (phosphoadenosine-phosphosulfate) synthesis from inorganic sulphate [2]. ATP sulfurylase catalyses the synthesis of adenosine-phosphosulfate APS from ATP and inorganic sulphate [1].	Domain
A, B, C	PF01583	Adenylylsulphate kinase (APS_kinase)	Adenylylsulphate kinase	Enzyme that catalyses the phosphorylation of adenylylsulphate to 3'-phosphoadenylylsulfate. This domain contains an ATP binding P-loop motif.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	sulfate adenylyltransferase	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding adenylyltransferase activity transferase activity sulfate adenylyltransferase (ATP) activity sulfate adenylyltransferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups kinase activity adenylylsulfate kinase activity phosphotransferase activity, alcohol group as acceptor	sulfur compound biosynthetic process biosynthetic process sulfur compound metabolic process metabolic process cellular process hydrogen sulfide biosynthetic process hydrogen sulfide metabolic process sulfate assimilation sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) sulfate assimilation via adenylyl sulfate reduction	cellular anatomical structure intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR015947	PUA-like superfamily	Homologous Superfamily
A, B, C	IPR025980	ATP-sulfurylase PUA-like domain	Domain
A, B, C	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold	Homologous Superfamily
A, B, C	IPR027535	Sulfate adenylyltransferase	Family
A, B, C	IPR002891	Adenylyl-sulfate kinase	Family
A, B, C	IPR002650	Sulphate adenylyltransferase	Family
A, B, C	IPR024951	Sulphate adenylyltransferase catalytic domain	Domain
A, B, C	IPR050512	Sulfate Adenylyltransferase/APS Kinase	Family
A, B, C	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.