1MEZ

Structure of the Recombinant Mouse-Muscle Adenylosuccinate Synthetase Complexed with SAMP, GDP, SO4(2-), and Mg(2+)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1meza_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	Nitrogenase iron protein-like	Adenylosuccinate synthetase, PurA	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Simibi-like P-loop NTPases	8089707	3002018	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Adenylsucc_synt	e1mezA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Adenylsucc_synt	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.440.10	Alpha Beta	3-Layer(aba) Sandwich	Adenylosuccinate Synthetase	Chain A, domain 1	CATH (4.3.0)
A	1.10.300.10	Mainly Alpha	Orthogonal Bundle	Adenylosuccinate Synthetase, subunit A	domain 2	CATH (4.3.0)
A	3.90.170.10	Alpha Beta	Alpha-Beta Complex	Adenylosuccinate Synthetase	Chain A, domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00709	Adenylosuccinate synthetase (Adenylsucc_synt)	Adenylosuccinate synthetase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Adenylosuccinate Synthetase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding actin filament binding adenylosuccinate synthase activity catalytic activity ligase activity, forming carbon-nitrogen bonds cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding actin filament binding adenylosuccinate synthase activity catalytic activity ligase activity, forming carbon-nitrogen bonds ligase activity guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides identical protein binding	nucleoside phosphate metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process metabolic process cellular process small molecule metabolic process phosphorus metabolic process ribose phosphate metabolic process nucleoside phosphate metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process metabolic process cellular process small molecule metabolic process phosphorus metabolic process ribose phosphate metabolic process purine ribonucleoside monophosphate biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process AMP metabolic process nucleotide salvage ribonucleotide biosynthetic process purine nucleoside monophosphate biosynthetic process purine ribonucleoside monophosphate metabolic process ribonucleotide metabolic process ribonucleoside monophosphate metabolic process purine-containing compound biosynthetic process purine nucleoside monophosphate metabolic process purine nucleotide salvage AMP salvage ribose phosphate biosynthetic process cellular metabolic compound salvage nucleoside monophosphate metabolic process carbohydrate derivative biosynthetic process purine-containing compound salvage nucleobase-containing compound biosynthetic process nucleoside monophosphate biosynthetic process biosynthetic process purine ribonucleotide salvage organophosphate biosynthetic process AMP biosynthetic process nucleoside phosphate biosynthetic process purine ribonucleotide metabolic process ribonucleoside monophosphate biosynthetic process purine nucleotide biosynthetic process 'de novo' AMP biosynthetic process oxoacid metabolic process dicarboxylic acid metabolic process aspartate family amino acid metabolic process carboxylic acid metabolic process amino acid metabolic process organic acid metabolic process alpha-amino acid metabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process aspartate metabolic process IMP metabolic process	cellular anatomical structure membrane intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001114	Adenylosuccinate synthetase	Family
A	IPR033128	Adenylosuccinate synthase, active site	Active Site
A	IPR027509	Adenylosuccinate synthetase isozyme 1, chordates	Family
A	IPR042110	Adenylosuccinate synthetase, domain 2	Homologous Superfamily
A	IPR018220	Adenylosuccinate synthase, GTP-binding site	Binding Site
A	IPR042111	Adenylosuccinate synthetase, domain 3	Homologous Superfamily
A	IPR042109	Adenylosuccinate synthetase, domain 1	Homologous Superfamily
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.