1MLA

THE ESCHERICHIA COLI MALONYL-COA:ACYL CARRIER PROTEIN TRANSACYLASE AT 1.5-ANGSTROMS RESOLUTION. CRYSTAL STRUCTURE OF A FATTY ACID SYNTHASE COMPONENT


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyProbable ACP-binding domain of malonyl-CoA ACP transacylase 8023159 4001289 SCOP2 (2022-06-29)
ASCOP2 FamilyFabD-like 8031640 4003614 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyProbable ACP-binding domain of malonyl-CoA ACP transacylase 8035539 3001224 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyFabD/lysophospholipase-like 8044018 3001121 SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AAcyl_transf_1_2nde1mlaA1 A: a+b two layersX: Alpha-beta plaitsH: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology)T: Probable ACP-binding domain of malonyl-CoA ACP transacylaseF: Acyl_transf_1_2ndECOD (1.6)
AAcyl_transf_1_1ste1mlaA2 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: FabD/lysophospholipase-likeF: Acyl_transf_1_1stECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.30.70.250 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits Malonyl-CoA ACP transacylase, ACP-bindingCATH (4.3.0)
A3.40.366.10 Alpha Beta 3-Layer(aba) Sandwich Malonyl-Coenzyme A Acyl Carrier Protein domain 2CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00698Acyl transferase domain (Acyl_transf_1)Acyl transferase domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
malonyl-CoA-acyl carrier protein transacylase  M-CSA #291

In Escherichia coli Fatty acid synthesis, FAS II includes a specific malonyl-CoA:ACP transacylase (MCAT), which catalyses specifically the elongation step. The initiation of each elongation step in the fatty acid synthesis cycle requires the transfer of a malonyl moiety from the respective CoA thioester to the -SH group of the phosphopantetheine arm of the acyl carrier protein (ACP), the central component of any FAS. MCAT, along with Acyl-carrier-protein S-acetyltransferase (EC 2.3.1.38), is essential for the initiation of fatty-acid biosynthesis in bacteria. This enzyme also provides the malonyl groups for polyketide biosynthesis.

Defined by 6 residues: GLN:A-11SER:A-92LEU:A-93ARG:A-117HIS:A-201GLN:A-250
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