1NE7

HUMAN GLUCOSAMINE-6-PHOSPHATE DEAMINASE ISOMERASE AT 1.75 A RESOLUTION COMPLEXED WITH N-ACETYL-GLUCOSAMINE-6-PHOSPHATE AND 2-DEOXY-2-AMINO-GLUCITOL-6-PHOSPHATE

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ne7a_	Alpha and beta proteins (a/b)	NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	NagB-like	Glucosamine 6-phosphate deaminase/isomerase NagB	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1ne7b_	Alpha and beta proteins (a/b)	NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	NagB-like	Glucosamine 6-phosphate deaminase/isomerase NagB	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1ne7c_	Alpha and beta proteins (a/b)	NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	NagB-like	Glucosamine 6-phosphate deaminase/isomerase NagB	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d1ne7d_	Alpha and beta proteins (a/b)	NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	NagB-like	Glucosamine 6-phosphate deaminase/isomerase NagB	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d1ne7e_	Alpha and beta proteins (a/b)	NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	NagB-like	Glucosamine 6-phosphate deaminase/isomerase NagB	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d1ne7f_	Alpha and beta proteins (a/b)	NagB/RpiA/CoA transferase-like	NagB/RpiA/CoA transferase-like	NagB-like	Glucosamine 6-phosphate deaminase/isomerase NagB	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	NagB-like	8024407	4003912	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	NagB/RpiA/CoA transferase-like	8036786	3000693	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	NagB/RpiA/CoA transferase-like	8036786	3000693	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	NagB/RpiA/CoA transferase-like	8036786	3000693	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	NagB/RpiA/CoA transferase-like	8036786	3000693	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	NagB/RpiA/CoA transferase-like	8036786	3000693	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	NagB/RpiA/CoA transferase-like	8036786	3000693	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Glucosamine_iso	e1ne7A1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: Glucosamine_iso	ECOD (1.6)
B	Glucosamine_iso	e1ne7B1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: Glucosamine_iso	ECOD (1.6)
C	Glucosamine_iso	e1ne7C1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: Glucosamine_iso	ECOD (1.6)
D	Glucosamine_iso	e1ne7D1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: Glucosamine_iso	ECOD (1.6)
E	Glucosamine_iso	e1ne7E1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: Glucosamine_iso	ECOD (1.6)
F	Glucosamine_iso	e1ne7F1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: Glucosamine_iso	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1360	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
B	3.40.50.1360	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
C	3.40.50.1360	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
D	3.40.50.1360	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
E	3.40.50.1360	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
F	3.40.50.1360	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF01182	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase (Glucosamine_iso)	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Glucosamine-6-phosphate isomerase	glucosamine-6-phosphate deaminase activity hydrolase activity deaminase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds isomerase activity identical protein binding protein binding binding	carbohydrate derivative catabolic process catabolic process amino sugar catabolic process glucosamine catabolic process amino sugar metabolic process carbohydrate derivative metabolic process metabolic process glucosamine metabolic process glucosamine-containing compound metabolic process glucosamine-containing compound catabolic process carbohydrate metabolic process primary metabolic process organonitrogen compound catabolic process N-acetylneuraminate catabolic process carbohydrate derivative catabolic process catabolic process amino sugar catabolic process glucosamine catabolic process amino sugar metabolic process carbohydrate derivative metabolic process metabolic process glucosamine metabolic process glucosamine-containing compound metabolic process glucosamine-containing compound catabolic process carbohydrate metabolic process primary metabolic process organonitrogen compound catabolic process N-acetylneuraminate catabolic process organonitrogen compound metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process organic acid catabolic process organic acid metabolic process cellular catabolic process carboxylic acid catabolic process small molecule metabolic process cellular process amide metabolic process small molecule catabolic process N-acetylneuraminate metabolic process carbohydrate derivative biosynthetic process amino sugar biosynthetic process nucleotide-sugar metabolic process nucleobase-containing compound biosynthetic process UDP-N-acetylglucosamine biosynthetic process nucleobase-containing compound metabolic process biosynthetic process nucleobase-containing small molecule metabolic process nucleotide-sugar biosynthetic process UDP-N-acetylglucosamine metabolic process phosphorus metabolic process sexual reproduction reproductive process fertilization single fertilization generation of precursor metabolites and energy N-acetylglucosamine catabolic process N-acetylglucosamine metabolic process	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR006148	Glucosamine/galactosamine-6-phosphate isomerase	Domain
A, B, C, D, E A, B, C, D, E, F	IPR018321	Glucosamine-6-phosphate isomerase, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F	IPR004547	Glucosamine-6-phosphate isomerase	Family
A, B, C, D, E A, B, C, D, E, F	IPR037171	NagB/RpiA transferase-like	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F	Pharos: P46926	Liver Cirrhosis, Experimental allergic rhinitis Crohn disease ovarian cancer astrocytic tumor glioblastoma primary biliary cholangitis atypical teratoid rhabdoid tumor subependymal giant cell astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.