1NNT

STRUCTURAL EVIDENCE FOR A PH-SENSITIVE DI-LYSINE TRIGGER IN THE HEN OVOTRANSFERRIN N-LOBE: IMPLICATIONS FOR TRANSFERRIN IRON RELEASE

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1nnta_	Alpha and beta proteins (a/b)	Periplasmic binding protein-like II	Periplasmic binding protein-like II	Transferrin	Ovotransferrin	chicken (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Transferrin	8021038	4000858	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Type 2 solute binding protein-like	8033418	3000083	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Transferrin_2nd	e1nntA1	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: Transferrin_2nd	ECOD (1.6)
A	Transferrin_1st	e1nntA2	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: Transferrin_1st	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.190.10	Alpha Beta	3-Layer(aba) Sandwich	D-Maltodextrin-Binding Protein	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00405	Transferrin (Transferrin)	Transferrin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	OVOTRANSFERRIN	cation binding ferric iron binding transition metal ion binding iron ion binding ion binding binding metal ion binding small molecule binding	response to stimulus response to chemical response to xenobiotic stimulus localization transport iron ion transport transition metal ion transport monoatomic ion transport monoatomic cation transport establishment of localization metal ion transport acute-phase response defense response response to stress response to stimulus response to chemical response to xenobiotic stimulus localization transport iron ion transport transition metal ion transport monoatomic ion transport monoatomic cation transport establishment of localization metal ion transport acute-phase response defense response response to stress inflammatory response acute inflammatory response humoral immune response biological process involved in interspecies interaction between organisms response to other organism immune response defense response to symbiont response to external stimulus antimicrobial humoral response response to biotic stimulus defense response to other organism immune system process response to external biotic stimulus antibacterial humoral response defense response to bacterium response to bacterium cellular localization inorganic ion homeostasis homeostatic process sequestering of metal ion maintenance of location in cell maintenance of location extracellular sequestering of iron ion intracellular iron ion homeostasis cellular homeostasis chemical homeostasis sequestering of iron ion intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis cellular process monoatomic cation homeostasis intracellular monoatomic ion homeostasis intracellular sequestering of iron ion response to lipid response to oxygen-containing compound response to lipopolysaccharide response to molecule of bacterial origin	membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle recycling endosome membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cellular anatomical structure cytoplasmic vesicle organelle cytoplasm vesicle recycling endosome organomineral extracellular matrix cell periphery extracellular matrix external encapsulating structure plasma membrane membrane extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR016357	Transferrin	Family
A	IPR001156	Transferrin-like domain	Domain
A	IPR018195	Transferrin family, iron binding site	Binding Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.