Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2B SuperfamilyComposite domain of metallo-dependent hydrolases 8043944 3000176 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyMetallo-dependent hydrolases 8043946 3000428 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyComposite domain of metallo-dependent hydrolases 8043944 3000176 SCOP2B (2022-06-29)
ASCOP2 FamilyN-acetylglucosamine-6-phosphate deacetylase, NagA 8031566 4002805 SCOP2 (2022-06-29)
ASCOP2 FamilyN-acetylglucosamine-6-phosphate deacetylase, NagA, catalytic domain 8031568 4002851 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyComposite domain of metallo-dependent hydrolases 8043944 3000176 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyMetallo-dependent hydrolases 8043946 3000428 SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
BIsoaspartyl-dipeptidasee1o12B1 A: beta sandwichesX: Composite domain of metallo-dependent hydrolases (From Topology)H: Composite domain of metallo-dependent hydrolases (From Topology)T: Composite domain of metallo-dependent hydrolasesF: Isoaspartyl-dipeptidaseECOD (1.6)
BAmidohydro_1_Ne1o12B2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: Amidohydro_1_NECOD (1.6)
AIsoaspartyl-dipeptidasee1o12A1 A: beta sandwichesX: Composite domain of metallo-dependent hydrolases (From Topology)H: Composite domain of metallo-dependent hydrolases (From Topology)T: Composite domain of metallo-dependent hydrolasesF: Isoaspartyl-dipeptidaseECOD (1.6)
AAmidohydro_1_Ne1o12A2 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: Amidohydro_1_NECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
B2.30.40.10 Mainly Beta Roll Urease, subunit C domain 1CATH (4.3.0)
B3.20.20.140 Alpha Beta Alpha-Beta Barrel TIM Barrel Metal-dependent hydrolasesCATH (4.3.0)
A2.30.40.10 Mainly Beta Roll Urease, subunit C domain 1CATH (4.3.0)
A3.20.20.140 Alpha Beta Alpha-Beta Barrel TIM Barrel Metal-dependent hydrolasesCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF01979Amidohydrolase family (Amidohydro_1)Amidohydrolase familyThis family of enzymes are a a large metal dependent hydrolase superfamily [1]. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisatio ...This family of enzymes are a a large metal dependent hydrolase superfamily [1]. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source [2]. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate + H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit [3]. Dihydroorotases (EC:3.5.2.3) are also included [4-5].
Domain