1O27

Crystal structure of Thymidylate Synthase Complementing Protein (TM0449) from Thermotoga maritima with FAD and BrdUMP at 2.3 A resolution

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1o27a1	Alpha and beta proteins (a+b)	Thymidylate synthase-complementing protein Thy1	Thymidylate synthase-complementing protein Thy1	Thymidylate synthase-complementing protein Thy1	Thy1 homologue	(Thermotoga maritima ) [TaxId: 2336 ],	SCOPe (2.08)
A	d1o27a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Thermotoga maritima ) [TaxId: 2336 ],	SCOPe (2.08)
B	d1o27b_	Alpha and beta proteins (a+b)	Thymidylate synthase-complementing protein Thy1	Thymidylate synthase-complementing protein Thy1	Thymidylate synthase-complementing protein Thy1	Thy1 homologue	(Thermotoga maritima ) [TaxId: 2336 ],	SCOPe (2.08)
C	d1o27c_	Alpha and beta proteins (a+b)	Thymidylate synthase-complementing protein Thy1	Thymidylate synthase-complementing protein Thy1	Thymidylate synthase-complementing protein Thy1	Thy1 homologue	(Thermotoga maritima ) [TaxId: 2336 ],	SCOPe (2.08)
D	d1o27d_	Alpha and beta proteins (a+b)	Thymidylate synthase-complementing protein Thy1	Thymidylate synthase-complementing protein Thy1	Thymidylate synthase-complementing protein Thy1	Thy1 homologue	(Thermotoga maritima ) [TaxId: 2336 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Thymidylate synthase-complementing protein Thy1	8033842	3000969	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Thymidylate synthase-complementing protein Thy1	8033842	3000969	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Thymidylate synthase-complementing protein Thy1	8033842	3000969	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Thymidylate synthase-complementing protein Thy1	8033842	3000969	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Thy1	e1o27A1	A: a+b two layers	X: Thymidylate synthase-complementing protein Thy1 (From Topology)	H: Thymidylate synthase-complementing protein Thy1 (From Topology)	T: Thymidylate synthase-complementing protein Thy1	F: Thy1	ECOD (1.6)
B	Thy1	e1o27B1	A: a+b two layers	X: Thymidylate synthase-complementing protein Thy1 (From Topology)	H: Thymidylate synthase-complementing protein Thy1 (From Topology)	T: Thymidylate synthase-complementing protein Thy1	F: Thy1	ECOD (1.6)
C	Thy1	e1o27C1	A: a+b two layers	X: Thymidylate synthase-complementing protein Thy1 (From Topology)	H: Thymidylate synthase-complementing protein Thy1 (From Topology)	T: Thymidylate synthase-complementing protein Thy1	F: Thy1	ECOD (1.6)
D	Thy1	e1o27D1	A: a+b two layers	X: Thymidylate synthase-complementing protein Thy1 (From Topology)	H: Thymidylate synthase-complementing protein Thy1 (From Topology)	T: Thymidylate synthase-complementing protein Thy1	F: Thy1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.1360.170	Alpha Beta	2-Layer Sandwich	Gyrase A	domain 2	CATH (4.3.0)
B	3.30.1360.170	Alpha Beta	2-Layer Sandwich	Gyrase A	domain 2	CATH (4.3.0)
C	3.30.1360.170	Alpha Beta	2-Layer Sandwich	Gyrase A	domain 2	CATH (4.3.0)
D	3.30.1360.170	Alpha Beta	2-Layer Sandwich	Gyrase A	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF02511	Thymidylate synthase complementing protein (Thy1)	Thymidylate synthase complementing protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Thymidylate synthase thyX	binding nucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding heterocyclic compound binding NADPH binding NADP binding small molecule binding transferase activity, transferring one-carbon groups transferase activity binding nucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding heterocyclic compound binding NADPH binding NADP binding small molecule binding transferase activity, transferring one-carbon groups transferase activity methyltransferase activity thymidylate synthase activity 5,10-methylenetetrahydrofolate-dependent methyltransferase activity catalytic activity thymidylate synthase (FAD) activity flavin adenine dinucleotide binding	methylation metabolic process pyrimidine deoxyribonucleotide metabolic process deoxyribose phosphate biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process pyrimidine nucleotide metabolic process pyrimidine deoxyribonucleoside monophosphate metabolic process nucleobase-containing compound metabolic process deoxyribonucleotide biosynthetic process deoxyribonucleotide metabolic process pyrimidine deoxyribonucleotide biosynthetic process nucleobase-containing small molecule metabolic process dTMP metabolic process methylation metabolic process pyrimidine deoxyribonucleotide metabolic process deoxyribose phosphate biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process pyrimidine nucleotide metabolic process pyrimidine deoxyribonucleoside monophosphate metabolic process nucleobase-containing compound metabolic process deoxyribonucleotide biosynthetic process deoxyribonucleotide metabolic process pyrimidine deoxyribonucleotide biosynthetic process nucleobase-containing small molecule metabolic process dTMP metabolic process phosphate-containing compound metabolic process deoxyribonucleoside monophosphate biosynthetic process dTMP biosynthetic process small molecule metabolic process pyrimidine deoxyribonucleoside monophosphate biosynthetic process pyrimidine-containing compound biosynthetic process nucleoside monophosphate metabolic process phosphorus metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process pyrimidine nucleoside monophosphate metabolic process pyrimidine-containing compound metabolic process cellular metabolic process 2'-deoxyribonucleotide metabolic process 2'-deoxyribonucleotide biosynthetic process primary metabolic process nucleotide metabolic process deoxyribose phosphate metabolic process nucleobase-containing compound biosynthetic process deoxyribonucleoside monophosphate metabolic process nucleoside monophosphate biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process cellular process pyrimidine nucleoside monophosphate biosynthetic process pyrimidine nucleotide biosynthetic process pyrimidine deoxyribonucleoside triphosphate biosynthetic process dTTP biosynthetic process pyrimidine deoxyribonucleoside triphosphate metabolic process pyrimidine nucleoside triphosphate biosynthetic process pyrimidine nucleoside triphosphate metabolic process dTTP metabolic process nucleoside triphosphate biosynthetic process nucleoside triphosphate metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR003669	Thymidylate synthase ThyX	Family
A, B, C, D	IPR036098	Thymidylate synthase ThyX superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.