1OP9

Complex of human lysozyme with camelid VHH HL6 antibody fragment

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1op9b_	Alpha and beta proteins (a+b)	Lysozyme-like	Lysozyme-like	C-type lysozyme	Lysozyme	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1op9a1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	Camelid IG heavy chain variable domain, VHh	Arabian camel (Camelus dromedarius ) [TaxId: 9838 ],	SCOPe (2.08)
A	d1op9a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Arabian camel (Camelus dromedarius ) [TaxId: 9838 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Lysozyme-like	8043304	3001879	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Lys	e1op9B1	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Lys	ECOD (1.6)
A	V-set_12	e1op9A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.10.530.10	Mainly Alpha	Orthogonal Bundle	Lysozyme		CATH (4.3.0)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A	VHH HL6, anti-lysozyme C [human]	VH	Camelus dromedarius (Arabian camel)	IGHV3S4501, IGHJ401	V-DOMAIN VH	IG	(VH)	IMGT (202446-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
A	Heavy Chain	IGHV1	-	lysozyme c	SAbDab (2024-11-15)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF00062	C-type lysozyme/alpha-lactalbumin family (Lys)	C-type lysozyme/alpha-lactalbumin family	Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bac ...	Alpha-lactalbumin is the regulatory subunit of lactose synthase, changing the substrate specificity of galactosyltransferase from N-acetylglucosamine to glucose. C-type lysozymes are secreted bacteriolytic enzymes that cleave the peptidoglycan of bacterial cell walls. Structure is a multi-domain, mixed alpha and beta fold, containing four conserved disulfide bonds.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	Lysozyme C	hydrolase activity, acting on glycosyl bonds peptidoglycan muralytic activity hydrolase activity, hydrolyzing O-glycosyl compounds lysozyme activity hydrolase activity catalytic activity identical protein binding protein binding binding	humoral immune response biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response immune response defense response to symbiont response to external stimulus antimicrobial humoral response response to biotic stimulus defense response to other organism response to stress immune system process response to external biotic stimulus humoral immune response biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response immune response defense response to symbiont response to external stimulus antimicrobial humoral response response to biotic stimulus defense response to other organism response to stress immune system process response to external biotic stimulus cellular process disruption of cell in another organism disruption of anatomical structure in another organism killing of cells of another organism cell killing defense response to Gram-negative bacterium defense response to bacterium response to bacterium inflammatory response defense response to Gram-positive bacterium	membrane-bounded organelle intracellular anatomical structure tertiary granule lumen membrane-enclosed lumen intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen tertiary granule intracellular organelle cellular anatomical structure organelle lumen cytoplasmic vesicle organelle membrane-bounded organelle intracellular anatomical structure tertiary granule lumen membrane-enclosed lumen intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen tertiary granule intracellular organelle cellular anatomical structure organelle lumen cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle extracellular region extracellular exosome extracellular vesicle extracellular organelle extracellular space extracellular membrane-bounded organelle vesicle lumen cytoplasmic vesicle lumen secretory granule lumen specific granule lumen specific granule lytic vacuole vacuolar lumen lysosome azurophil granule vacuole azurophil granule lumen primary lysosome
A	HL6 camel VHH fragment	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR001916	Glycoside hydrolase, family 22	Family
B	IPR023346	Lysozyme-like domain superfamily	Homologous Superfamily
B	IPR019799	Glycoside hydrolase family 22 domain	Domain
B	IPR000974	Glycoside hydrolase, family 22, lysozyme	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: P61626	familial visceral amyloidosis amyloidosis Hereditary lysozyme Amyloidosis juvenile dermatomyositis lung cancer malignant ependymoma acquired metabolic disease medulloblastoma atypical teratoid rhabdoid tumor osteosarcoma Becker muscular dystrophy pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia chronic kidney disease primitive neuroectodermal tumor dermatomyositis familial visceral amyloidosis amyloidosis Hereditary lysozyme Amyloidosis juvenile dermatomyositis lung cancer malignant ependymoma acquired metabolic disease medulloblastoma atypical teratoid rhabdoid tumor osteosarcoma Becker muscular dystrophy pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia chronic kidney disease primitive neuroectodermal tumor dermatomyositis Sjogren syndrome ductal breast carcinoma in situ interstitial cystitis limb-girdle muscular dystrophy lung carcinoma malignant glioma nephrosclerosis B-cell chronic lymphocytic leukemia ovarian cancer breast cancer periodic fever syndrome Crohn disease psoriasis diabetes mellitus tuberculosis Emery-Dreifuss muscular dystrophy glioblastoma invasive ductal breast carcinoma lung adenocarcinoma lymphoplasmacytic lymphoma malignant pancreatic neoplasm attention deficit hyperactivity disorder, inattentive type non-small cell lung carcinoma Barrett esophagus pancreatic intraductal papillary-mucinous carcinoma breast carcinoma pilocytic astrocytoma cutaneous lupus erythematosus sinusitis Duchenne muscular dystrophy ulcerative colitis esophageal adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.