Annotations: 1PYU

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1pyu.1	All beta proteins	Double psi beta-barrel	ADC-like	Pyruvoyl dependent aspartate decarboxylase, ADC	Pyruvoyl dependent aspartate decarboxylase, ADC	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d1pyu.2	All beta proteins	Double psi beta-barrel	ADC-like	Pyruvoyl dependent aspartate decarboxylase, ADC	Pyruvoyl dependent aspartate decarboxylase, ADC	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1pyu.1	All beta proteins	Double psi beta-barrel	ADC-like	Pyruvoyl dependent aspartate decarboxylase, ADC	Pyruvoyl dependent aspartate decarboxylase, ADC	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D	d1pyu.2	All beta proteins	Double psi beta-barrel	ADC-like	Pyruvoyl dependent aspartate decarboxylase, ADC	Pyruvoyl dependent aspartate decarboxylase, ADC	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.40.40.20	Mainly Beta	Beta Barrel	Barwin-like endoglucanases		CATH (4.3.0)
D	2.40.40.20	Mainly Beta	Beta Barrel	Barwin-like endoglucanases		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, D	PF02261	Aspartate decarboxylase (Asp_decarbox)	Aspartate decarboxylase	Decarboxylation of aspartate is the major route of beta-alanine production in bacteria, and is catalysed by the enzyme aspartate decarboxylase EC:4.1.1.11 which requires a pyruvoyl group for its activity. It is synthesised initially as a proenzyme w ...	Decarboxylation of aspartate is the major route of beta-alanine production in bacteria, and is catalysed by the enzyme aspartate decarboxylase EC:4.1.1.11 which requires a pyruvoyl group for its activity. It is synthesised initially as a proenzyme which is then proteolytically cleaved to an alpha (C-terminal) and beta (N-terminal) subunit and a pyruvoyl group. This family contains both chains of aspartate decarboxylase.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Aspartate 1-decarboxylase beta chain	aspartate 1-decarboxylase activity carboxy-lyase activity lyase activity catalytic activity carbon-carbon lyase activity	oxoacid metabolic process cellular biosynthetic process vitamin biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process small molecule metabolic process amide metabolic process water-soluble vitamin metabolic process pantothenate metabolic process water-soluble vitamin biosynthetic process monocarboxylic acid biosynthetic process small molecule biosynthetic process cellular metabolic process oxoacid metabolic process cellular biosynthetic process vitamin biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process small molecule metabolic process amide metabolic process water-soluble vitamin metabolic process pantothenate metabolic process water-soluble vitamin biosynthetic process monocarboxylic acid biosynthetic process small molecule biosynthetic process cellular metabolic process carboxylic acid metabolic process amide biosynthetic process vitamin metabolic process cellular modified amino acid metabolic process biosynthetic process cellular modified amino acid biosynthetic process pantothenate biosynthetic process metabolic process cellular process monocarboxylic acid metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation protein autoprocessing proteolysis protein processing protein metabolic process macromolecule metabolic process amino acid metabolic process alpha-amino acid metabolic process amino acid biosynthetic process alanine biosynthetic process alanine metabolic process alpha-amino acid biosynthetic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol
B, D	Aspartate 1-decarboxylase alfa chain	aspartate 1-decarboxylase activity carboxy-lyase activity lyase activity catalytic activity carbon-carbon lyase activity	oxoacid metabolic process cellular biosynthetic process vitamin biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process small molecule metabolic process amide metabolic process water-soluble vitamin metabolic process pantothenate metabolic process water-soluble vitamin biosynthetic process monocarboxylic acid biosynthetic process small molecule biosynthetic process cellular metabolic process oxoacid metabolic process cellular biosynthetic process vitamin biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process small molecule metabolic process amide metabolic process water-soluble vitamin metabolic process pantothenate metabolic process water-soluble vitamin biosynthetic process monocarboxylic acid biosynthetic process small molecule biosynthetic process cellular metabolic process carboxylic acid metabolic process amide biosynthetic process vitamin metabolic process cellular modified amino acid metabolic process biosynthetic process cellular modified amino acid biosynthetic process pantothenate biosynthetic process metabolic process cellular process monocarboxylic acid metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation protein autoprocessing proteolysis protein processing protein metabolic process macromolecule metabolic process amino acid metabolic process alpha-amino acid metabolic process amino acid biosynthetic process alanine biosynthetic process alanine metabolic process alpha-amino acid biosynthetic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR003190	Aspartate decarboxylase	Family
A, C	IPR009010	Aspartate decarboxylase-like domain superfamily	Homologous Superfamily
B, D	IPR003190	Aspartate decarboxylase	Family
B, D	IPR009010	Aspartate decarboxylase-like domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.